Principal models related to immune responsiveness

	Immune Landscapea	References
WNT/βCatenin	Silent (0.03)	[38, 39]
MAPK Hypothesis	Silent (0.001)	[10]
Immunogenic Cell Death	Active (< 0.001)	[19], [20, 21]
Regulatory T cells	Active (< 0.001)	[24, 25]
IL23-Th17 Axis	Active (< 0.001)	[26, 41–44]
Myeloid Suppressor Cells	Active (< 0.001)	[50]
PI3K-γ Signature	Active (< 0.01)	[52–55, 63]
IDO/NOS Signature	Active (< 0.01)	[51, 81, 82]
SGK1 Signature	Ubiquitous	[56, 57]
Shc1 signature	Ubiquitous	[62]
Barrier Molecules	Ubiquitous	[27, 28]
Mesenchymal Transition	Ubiquitous	[29, 30, 83]
Cancer-Associated Fibroblasts	Ubiquitous	[31–35, 84]
TAM receptor tyrosine kinases	Ubiquitous	[47, 58–60, 85]
Hypoxia/Adenosine suppression	Ubiquitous	[48, 49]
TREX1clearence of Cytosolic DNA	NA	[86, 87]
Checkpoint Cluster	Active (< 0.001)	[22, 23]
oncogene addicted tumors	Silent	[11, 68]
Epigenetic Regulation	Ubiquitous	[12, 88–90]

^aDistinct models have been assigned to either the Silent or the Active Landscape according to the results of the survey shown in Fig. 1 . Ubiquitous refers to models that are not significantly associated with either immune landscape