Macrophage-associated cytokine parameters based on proteomic analysis in Frieboes et al. [48]
| Parameter | Function | Value |
|---|---|---|
| λ¯circulationC\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {\overline{\lambda}}_{circulation}^C $$\end{document} | Wash-out rate into vasculature | 0.006 (*) |
| λ¯decayC\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {\overline{\lambda}}_{decay}^C $$\end{document} | Decay rate | 0.001 (*) |
| DM1f | Diffusivity for M1f | 0.005 (*) |
| DM2f | Diffusivity for M2f | 0.01880 (*) |
| DIL − 10 | Diffusivity for IL-10 | 0.01880 (*) |
| DT2f | Diffusivity for T2f | 0.005 (*) |
| DAng2 | Diffusivity for Ang2 | 0.00133 (*) |
| λ¯productionM1f\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {\overline{\lambda}}_{production}^{M1f} $$\end{document} | production rate of M1f | 1.0 (**) |
| λ¯productionM2f\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {\overline{\lambda}}_{production}^{M2f} $$\end{document} | production rate of M2f | 1.0 (**) |
| λ¯productionIL−10\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {\overline{\lambda}}_{production}^{IL-10} $$\end{document} | production rate of IL-10 | 1.0 (**) |
| λ¯productionT2f\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {\overline{\lambda}}_{production}^{T2f} $$\end{document} | production rate of T2f | 1.0 (**) |
| λ¯productionAng2\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {\overline{\lambda}}_{production}^{Ang2} $$\end{document} | production rate of Ang2 | 1.0 (**) |
The same wash-out and decay rates apply to all cytokines, generically denoted by C. (*) Value is non-dimensionalized by the diffusivity of oxygen [68] (1 × 10−5 cm2 s−1). (**) Value is rescaled by the production rate of VEGF-A (VEGF -165) protein, representing a typical TAF molecule