Genes in the Tumor Inflammation Signature

TIS Biology	Gene	Protein	Function
Antigen Presenting Cell Abundance	PSMB10	PSB10	Immunoproteosome Subunit
	HLA-DQA1	MHC class II DQA1	MHC Class II Antigen Presentation
	HLA-DRB1	MHC class II DRB1	MHC Class II Antigen Presentation
	CMKLR1	CML1	Chemokine Receptor
T Cell/ NK Cell Abundance	HLA-E	HLAE	Nonclassical Class I Antigen Presentation
	NKG7	NKG7	Cytolytic Granule Protein
	CD8A	CD8A	MHC Class I Coreceptor
IFN Activity	CCL5	CCL5	Monocytes and Memory T cells Chemoattractant
	CXCL9	CXCL9	Lymphocyte Chemoattractant
	CD27	CD27	Lymphocyte Activation
	CXCR6	CXCR6	T cell Activation
	IDO1	IDO	Inhibitor of T cell Proliferation and Function
	STAT1	STAT1	Transcription Factor Mediating IFN Response
T Cell Exhaustion	TIGIT	TIGIT	Inhibitor of T cell Function
	LAG3	LAG3	Inhibitor of T cell Function
	CD274	PD-L1	Inhibitor of T cell Function
	PDCD1LG2	PD-L2	Inhibitor of T cell Function
	CD276	B7-H3	Inhibitor of T cell Function