Univariate and Multivariable Cox Proportional Hazard Models of PFS vs BMI
| anti-CTLA-4 | anti-PD-1 | Combination | |||||
|---|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | ||
| Univariate Model | Overweight (vs Normal BMI) | 1.1(0.67,1.83) | 0.7 | 1.58(0.78,3.19) | 0.21 | 0.36(0.15,0.85) | 0.02 |
| Obesity (vs Normal BMI) | 0.98(0.59,1.63) | 0.93 | 1.49(0.71,3.13) | 0.3 | 0.17(0.04,0.65) | 0.01 | |
| Multivariable Model | Overweight (vs Normal BMI) | 0.97(0.56,1.69) | 0.92 | 2.34(1.05,5.2) | 0.04 | 0.5(0.15,1.71) | 0.27 |
| Obesity (vs Normal BMI) | 1.16(0.7,1.94) | 0.57 | 2.46(1.03,5.89) | 0.04 | 0.18(0.05,0.74) | 0.02 | |
| Female | 0.94(0.59,1.51) | 0.81 | 1.05(0.6,1.84) | 0.85 | 1.8(0.72,4.49) | 0.21 | |
| Age at Treatment Initiation | 1(0.98,1.01) | 0.77 | 0.99(0.97,1.01) | 0.28 | 0.99(0.95,1.03) | 0.67 | |
| Stage IV at Treatment Initiation(vs Stage III) | 3(1.07,8.41) | 0.04 | 0.88(0.3,2.64) | 0.82 | 0.19(0.02,1.62) | 0.13 | |
| ECOG Status | 1.78(1.22,2.6) | 0.003 | 2.67(1.65,4.31) | 0.003 | 3.02(1.44,6.32) | <.001 | |
| LDH High | 1.16(0.74,1.82) | 0.52 | 2.25(1.08,4.7) | 0.03 | 1.45(0.65,3.23) | 0.36 | |
| Number of Metastatic Sites | 1.21(1.04,1.4) | 0.02 | 1.11(0.91,1.36) | 0.29 | 0.94(0.7,1.25) | 0.68 | |
| BRAF Mutated | 0.86(0.37,2) | 0.73 | 0.43(0.12,1.6) | 0.21 | 1.83(0.61,5.54) | 0.28 | |