Cox proportional-hazards regression: univariate and multivariate analyses of Overall Survival

Overall Survival
Univariate AnalysisMultivariate Analysis
VARIABLE(Comparator)HR (95% CI); p – valueHR (95% CI); p - value
BMI≥ 25 vs < 250.33 (0.28–0.41); p < 0.00010.49 (0.38–0.64); p < 0.0001
Weighta0.97 (0.96–0.97); p < 0.00010.99 (0.99–1.01); p = 0.1884
irAEs of any gradeYes vs No0.45 (0.37–0.54); p < 0.00010.82 (0.65–1.04); p = 0.1085
Primary Tumor (NSCLC)
 Melanoma0.49 (0.38–0.64); p < 0.00010.67 (0.51–0.87); p = 0.0036
 Kidney0.56 (0.42–0.74); p = 0.00010.61 (0.45–0.80); p = 0.0005
 Others1.11 (0.62–1.96); p = 0.73370.71 (0.40–1.28); p = 0.2632
Sex Male vs Female1.50 (1.23–1.83); p < 0.00011.33 (1.09–1.63); p = 0.0044
Age Elderly vs Non-elderly1.11 (0.93–1.32); p = 0.2401
Treatment line Non-first vs First1.58 (1.26–1.97); p = 0.00011.42 (1.15–1.77); p = 0.0012
N° of metastatic sites > 2 vs ≤ 21.52 (1.29–1.78); p < 0.00011.41 (1.17–1.69); p = 0.0002
ECOG PS ≥2 vs 0–12.07 (1.87–2.29); p < 0.00012.59 (2.09–3.21); p < 0.0001

aWeight was used as a continuous variable