Multivariate analysis of CD8+PD-1+ double positive immune subsets with survival outcomes in patients with TNBC. Analysis was adjusted for tumor size, grade, age and lymph node status
| Biomarkers | HR | 95% CI | P-value |
|---|---|---|---|
| OS | |||
| CD8+PD-1+ immune infiltrates High vs. low | 0.56 | 0.29–1.06 | 0.073 |
| CD8+PD-1+ immune infiltrates High vs. low (adjusted for tumor size, grade, age and lymph node status and CD8+ total cell count) | 0.77 | 0.35–1.67 | 0.510 |
| DFS | |||
| CD8+PD-1+ immune infiltrates High vs. low | 0.47 | 0.28–0.80 | 0.006* |
| CD8+PD-1+ immune infiltrates High vs. low (adjusted for tumor size, grade, age and lymph node status and CD8+ total cell count) | 0.43 | 0.23–0.83 | 0.011* |
PD-1 programmed cell death protein-1, PD-L1 programmed cell death ligand 1
*Statistically significant