Comprehensive genomic profiling by FoundationOne™
| Patient | TMB | Genomic Findings |
|---|---|---|
| 4 | 15 muts/mb | CDKN2A/B lossCHEK2 R117GDNMT3A R771FANCD2 E118MLL3 splice site 2533-1G > ATP53 L145R, splice site 673-1G > A |
| 5 | 12 muts/mb | CRKL amplificationDNMT3A R635W – subclonalMAPK1 amplificationSF3B1 K700E – subclonalZRSR2 splice site 121 + 2 T > G |