Patient | Response | Characteristics (m1/f2; age (y3)) | Phototype | Histological type | BRAF Status (wt5/mut6) | Checkpoint inhibitor therapy | Number of involved organs | Metastasis | ECOG9 Performance status | Tumor Response at first CT scan10 |
---|---|---|---|---|---|---|---|---|---|---|
1 | Responders | m, 70 | 2 | SSM4 | mut | anti-PD17 | 2 | Lung, Lymph nodes | 0 | PR |
2 | m, 70 | 3 | SSM | wt | anti-PD1 | 3 | Soft tissue, Bone, Liver | 0–1 | SD* | |
3 | f, 78 | 2 | SSM | wt | anti-PD1 + anti-CTLA48 | 3 | Soft tissue, Lymph nodes, Lung | 0 | PR | |
4 | m, 63 | 3 | SSM | wt | anti-PD1 | 1 | Lung | 0 | PR | |
5 | m, 52 | 3 | SSM | mut | anti-PD1 + anti-CTLA4 | 4 | Mesenterium, Peritoneum, Retroperitoneum, Brain | 0 | SD* | |
6 | m, 86 | 3 | nodular | wt | anti-PD1 | 2 | Bone, Lung | 0 | PR | |
7 | f, 66 | 2 | nodular | mut | anti-CTLA4 | 5 | Lymph nodes, Lung, Soft tissue, Suprarenal gland, Stomach | 0 | PR | |
8 | f, 81 | 2 | nodular | wt | anti-PD1 | 5 | Lymph node, Soft tissue, Lung, Bone, Liver | 0 | PR | |
9 | f, 66 | 2 | nodular | wt | anti-PD1 | 3 | Soft tissue, Lymph nodes, Brain | 0 | PR | |
10 | m, 78 | 2 | nodular | wt | anti-PD1 | 3 | Soft Tissue, Lymph nodes, Lung | 0 | CR | |
11 | f, 61 | 1 | uveal | wt | anti-PD1 | 1 | Bone | 0 | PR | |
12 | m, 66 | 2 | mucosal | wt | anti-PD1 | 6 | Soft tissue, Lung, Pankreas, Small pelvis, Liver, Bone | 0 | PR | |
13 | Non-Responders | m, 62 | 2 | SSM | wt | anti-PD1 | 4 | Suprarenal gland, Lung, Lymph node, Brain | 0 | SD |
14 | f, 56 | 2 | SSM | mut | anti-PD1 + anti-CTLA4 | 5 | Lung, Lymph node, Soft tissue, Liver, Stomach | 1 | PD | |
15 | f, 87 | 3 | nodular | mut | anti-PD1 | 5 | Lung, Lymph node, Liver, Bone, Brain | 1 | SD | |
16 | f, 71 | 2 | uveal | wt | anti-CTLA4 | 3 | Lung, Liver, Brain | 0 | PD | |
17 | f, 71 | 2 | uveal | wt | anti-PD1 | 2 | Liver, Lymph node | 0 | SD | |
18 | f, 87 | 2 | mucuosal | wt | anti-PD1 | 1 | Soft tissue | 1 | PD | |
19 | f, 71 | 2 | unknown, amelanotic | wt | anti-PD1 | 3 | Lung, Lymph node, Suprarenal gland | 0 | SD | |
20 | m, 72 | 3 | unknown | wt | anti-PD1 | 7 | Lung, Liver, Lymph node, Suprarenal gland, Pankreas, Bone, Eye muscle | 0 | PD |
* pseudoprogression, 1 male, 2 female, 3 years, 4 superficial spreading melanoma, 5 wild type, 6 V600E mutation, 7 anti-programmed-cell-death protein-1, 8anti-cytotoxic-T-lymphocyte-associated-protein-4, 9Eastern Cooperative Oncology Group,10 CR Complete Remission, PR Partial Remission, SD Stable Disease, PD Progressive Disease