Variable | DLBCL (n = 148) | MZL (n = 49) | Follicular lymphoma (n = 25) | ||||||
---|---|---|---|---|---|---|---|---|---|
CH(n = 47) | CH-IT(n = 101) | P | CH(n = 24) | CH-IT(n = 25) | P | CH(n = 6) | CH-IT(n = 19) | P | |
Sex | 0.522 | 0.484 | 0.175 | ||||||
Male | 25 | 48 | 12 | 15 | 4 | 6 | |||
Female | 22 | 53 | 12 | 10 | 2 | 13 | |||
Median age(range) - years | 9 (3–12) | 7 (3–15) | 0.677 | 8 (3–15) | 7 (3–13) | 0.110 | 10 (6–11) | 9 (7–11) | 0.774 |
Median weight(range) - kg | 31.9 (4.1–60.0) | 28.8 (17–38) | 0.787 | 20.7 (3.0–42.3) | 26.0 (3.9–44.4) | 0.556 | 29 (20–40) | 20 (12–32) | 0.171 |
PCV | 0.063 | 0.189 | 0.430 | ||||||
normal | 46 | 89 | 20 | 24 | 5 | 18 | |||
decreased | 1 | 12 | 4 | 1 | 1 | 1 | |||
Platelet count | 0.127 | 0.138 | 0.999 | ||||||
normal | 34 | 84 | 18 | 23 | 5 | 17 | |||
decreased | 13 | 17 | 6 | 2 | 1 | 2 | |||
LDH | 0.689 | 0.567 | 0.999 | ||||||
normal | 23 | 53 | 15 | 13 | 4 | 11 | |||
increased | 24 | 48 | 9 | 12 | 2 | 8 | |||
Stage | 0.310 | 0.999 | 0.999 | ||||||
III-IV | 15 | 41 | 4 | 4 | 2 | 8 | |||
V | 32 | 60 | 20 | 21 | 4 | 11 | |||
Peripheral blood infiltration | 0.129 | 0.496 | 0.160 | ||||||
no | 17 | 50 | 6 | 4 | 5 | 8 | |||
yes | 30 | 51 | 18 | 21 | 1 | 11 | |||
Bone marrow infiltration | 0.647 | 0.791 | 0.999 | ||||||
no | 20 | 47 | 5 | 6 | 3 | 9 | |||
yes | 27 | 54 | 19 | 19 | 3 | 10 | |||
Extranodal involvement | 0.004* | 0.680 | 0.562 | ||||||
no | 33 | 90 | 17 | 19 | 4 | 16 | |||
yes | 14 | 11 | 7 | 6 | 2 | 3 | |||
Substage | 0.198 | 0.484 | 0.999 | ||||||
a | 27 | 69 | 14 | 17 | 5 | 14 | |||
b | 20 | 32 | 10 | 8 | 1 | 5 | |||
Steroids before referral | 0.284 | 0.038* | 0.540 | ||||||
no | 37 | 71 | 15 | 22 | 6 | 15 | |||
yes | 10 | 30 | 9 | 3 | 0 | 4 | |||
Rescue protocols | 0.275 | 0.696 | 0.400 | ||||||
untreated | 1 | 8 | 1 | 1 | 1 | 1 | |||
one RP administered | 10 | 21 | 3 | 8 | 1 | 5 | |||
more RP administered | 5 | 23 | 4 | 5 | 0 | 2 | |||
Toxicity | 0.167 | 0.667 | 0.211 | ||||||
none/grades 1–2 | 39 | 85 | 21 | 23 | 3 | 15 | |||
grades 3–4 | 5 | 15 | 3 | 2 | 2 | 3 | |||
grade 5 | 3 | 1 | 0 | 0 | 1 | 1 |
Abbreviations: DLBCL Diffuse large B-cell lymphoma, MZL marginal zone lymphoma, PCV Packed cell volume, LDH Lactate dehydrogenase, CH Chemotherapy, CH-IT Chemo-immunotherapy, RP Rescue protocol
*Significant