Outcomes after SIT

Characteristics	Failed steroid tapering after SIT		IMC recurrence
Characteristics	OR (95% CI)	P	OR (95% CI)	P
ICI type
Anti-PD-1/L1 monotherapy	Reference		Reference
Anti-CTLA-4 therapy	0.50 (0.19–1.29)	0.150	1.09 (0.36–3.37)	0.871
Colitis grade
1–2	Reference		Reference
3–4	4.09 (1.53–10.98)	0.005	1.79 (0.59–3.38)	0.299
Multiple hospitalizations	9.05 (2.79–29.33)	< 0.001	26.25 (3.22–213.82)	0.002
Failed steroid tapering before SIT	3.75 (1.39–10.16)	0.009	2.42 (0.75–7.77)	0.138
Failed steroid tapering after SIT	–	–	4.07 (1.29–12.88)	0.017
Type of SIT
Vedolizumab	Reference		Reference
Infliximab	0.47 (0.18–1.22)	0.120	12.57 (1.57–100.57)	0.017
No. of SIT infusions
1–2	Reference		Reference
≥3	2.97 (1.13–7.79)	0.027	0.09 (0.01–0.72)	0.023
Endoscopic remission	1.68 (0.41–6.96)	0.474	0.15 (0.03–0.79)	0.025
Histologic remission	0.67 (0.18–2.46)	0.543	0.18 (0.04–0.88)	0.033
Number of steroids tapering attempts	9.50 (3.76–24.01)	< 0.001	3.35 (1.68–6.69)	0.001
Duration from IMC onset to SIT	1.05 (1.01–1.09)	0.011	1.00 (0.98–1.03)	0.774
Overall duration of steroids	1.02 (1.01–1.04)	0.001	1.01 (1.00–1.03)	0.022
Calprotectin at time of onset	1.00 (0.99–1.00)	0.599	1.00 (0.99–1.01)	0.346
Calprotectin after SIT	1.00 (0.99–1.00)	0.573	1.01 (1.00–1.01)	0.014
Duration of hospitalization	1.12 (1.04–1.21)	0.004	1.14 (1.05–1.23)	0.001
Duration of symptoms	1.06 (1.03–1.08)	< 0.001	1.02 (1.01–1.03)	0.008

Abbreviations: CI, confidence interval; CTLA, cytotoxic T lymphocyte associated protein; SIT, selective immunosuppressive therapy; OR, odds ratio; PD-1, programmed death protein 1; PD-L1, PD-1 ligand