Cox proportional-hazards regression: univariate and multivariate analyses of Time to Treatment Failure

Time to Treatment Failure
Univariate AnalysisMultivariate Analysis
VARIABLE (Comparator)HR (95% CI); p - valueHR (95% CI); p - value
BMI≥ 25 vs < 250.51 (0.44–0.60); p < 0.00010.67 (0.53–0.85); p = 0.0009
Weighta0.98 (0.97–0.99); p < 0.00010.99 (0.98–1.01); p = 0.8422
irAEs of any gradeYes vs No0.57 (0.48–0.66); p < 0.00010.79 (0.65–0.97); p = 0.0295
Primary Tumor (NSCLC)
 Melanoma Kidney Others0.62 (0.50–0.76); p < 0.00010.73 (0.59–0.92); p = 0.00771.15 (0.71–1.87); p = 0.55600.79 (0.64–1.01); p = 0.05170.71 (0.56–0.88); p = 0.00250.78 (0.48–1.28); p = 0.3389
SexMale vs Female1.22 (1.04–1.43); p = 0.01471.10 (0.93–1.30); p = 0.2607
AgeElderly vs Non-elderly1.04 (0.90–1.21); p = 0.5366
Treatment lineNon-first vs First1.36 (1.13–1.64); p = 0.00081.51 (1.25–1.81); p < 0.0001
N° of metastatic sites> 2 vs ≤ 21.54 (1.34–1.77); p < 0.00011.52 (1.30–1.77); p < 0.0001
ECOG PS≥2 vs 0–12.86 (2.36–3.48); p < 0.00012.35 (1.92–2.88); p < 0.0001

aWeight was used as a continuous variable