Antibodies

Overcoming tumor heterogeneity by ex vivo arming of T cells using multiple bispecific antibodies
Jeong A Park, Nai-Kong V Cheung

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003771; DOI: 10.1136/jitc-2021-003771
Fc-null anti-PD-1 monoclonal antibodies deliver optimal checkpoint blockade in diverse immune environments
Julia Moreno-Vicente, Jane E Willoughby, Martin C Taylor, Steven G Booth, Vikki L English, Emily L Williams, Christine A Penfold, C Ian Mockridge, Tatyana Inzhelevskaya, Jinny Kim, H T Claude Chan, Mark S Cragg, Juliet C Gray, Stephen A Beers

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003735; DOI: 10.1136/jitc-2021-003735
Randomized, open-label, phase 2 study of andecaliximab plus nivolumab versus nivolumab alone in advanced gastric cancer identifies biomarkers associated with survival
Manish A Shah, David Cunningham, Jean-Philippe Metges, Eric Van Cutsem, Zev Wainberg, Emon Elboudwarej, Kai-Wen Lin, Scott Turner, Marianna Zavodovskaya, David Inzunza, Jinfeng Liu, Scott D Patterson, Jingzhu Zhou, Jing He, Dung Thai, Pankaj Bhargava, Carrie Baker Brachmann, Daniel V T Cantenacci

Journal for ImmunoTherapy of Cancer Dec 2021, 9 (12) e003580; DOI: 10.1136/jitc-2021-003580
Humoral and cellular correlates of a novel immune-related adverse event and its treatment
Amrit S Gonugunta, Mitchell S von Itzstein, Hong Mu-Mosley, Farjana Fattah, J David Farrar, Angela Mobely, Sawsan Rashdan, Sunny Lai, Salman F Bhai, Bonnie L Bermas, David Karp, Quan-Zhen Li, Edward K Wakeland, David E Gerber

Journal for ImmunoTherapy of Cancer Dec 2021, 9 (12) e003585; DOI: 10.1136/jitc-2021-003585
Spatiotemporal depletion of tumor-associated immune checkpoint PD-L1 with near-infrared photoimmunotherapy promotes antitumor immunity
Shunichi Taki, Kohei Matsuoka, Yuko Nishinaga, Kazuomi Takahashi, Hirotoshi Yasui, Chiaki Koike, Misae Shimizu, Mitsuo Sato, Kazuhide Sato

Journal for ImmunoTherapy of Cancer Oct 2021, 9 (11) e003036; DOI: 10.1136/jitc-2021-003036
Bispecific antibody-mediated redirection of NKG2D-CAR natural killer cells facilitates dual targeting and enhances antitumor activity
Congcong Zhang, Jasmin Röder, Anne Scherer, Malena Bodden, Jordi Pfeifer Serrahima, Anita Bhatti, Anja Waldmann, Nina Müller, Pranav Oberoi, Winfried S Wels

Journal for ImmunoTherapy of Cancer Oct 2021, 9 (10) e002980; DOI: 10.1136/jitc-2021-002980
Bispecific antibody targeting TROP2xCD3 suppresses tumor growth of triple negative breast cancer
Huicheng Liu, Lili Bai, Liu Huang, Na Ning, Lin Li, Yijia Li, Xuejiao Dong, Qiuyang Du, Minghui Xia, Yufei Chen, Likun Zhao, Yanhu Li, Qingwu Meng, Jing Wang, Yaqi Duan, Jie Ming, Andy Qingan Yuan, Xiang-Ping Yang

Journal for ImmunoTherapy of Cancer Oct 2021, 9 (10) e003468; DOI: 10.1136/jitc-2021-003468
Novel potent anti-STEAP1 bispecific antibody to redirect T cells for cancer immunotherapy
Tsung-Yi Lin, Jeong A Park, Alan Long, Hong-Fen Guo, Nai-Kong V Cheung

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e003114; DOI: 10.1136/jitc-2021-003114
First-in-human phase I/Ib open-label dose-escalation study of GWN323 (anti-GITR) as a single agent and in combination with spartalizumab (anti-PD-1) in patients with advanced solid tumors and lymphomas
Sarina A Piha-Paul, Ravit Geva, Tira J Tan, Darren WT Lim, Cinta Hierro, Toshikiko Doi, Osama Rahma, Alexander Lesokhin, Jason John Luke, Javier Otero, Lisa Nardi, Angad Singh, Alexandros Xyrafas, Xinhui Chen, Jennifer Mataraza, Philippe L Bedard

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e002863; DOI: 10.1136/jitc-2021-002863
GD2-directed bispecific trifunctional antibody outperforms dinutuximab beta in a murine model for aggressive metastasized neuroblastoma
Felix Zirngibl, Sara M Ivasko, Laura Grunewald, Anika Klaus, Silke Schwiebert, Peter Ruf, Horst Lindhofer, Kathy Astrahantseff, Lena Andersch, Johannes H Schulte, Holger N Lode, Angelika Eggert, Kathleen Anders, Patrick Hundsdoerfer, Annette Künkele

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002923; DOI: 10.1136/jitc-2021-002923

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