antibody affinity

Development of a TCR-like antibody and chimeric antigen receptor against NY-ESO-1/HLA-A2 for cancer immunotherapy
Xin Liu, Yixiang Xu, Wei Xiong, Bingnan Yin, Yuqian Huang, Junjun Chu, Changsheng Xing, Chen Qian, Yang Du, Tianhao Duan, Helen Y Wang, Ningyan Zhang, John S. Yu, Zhiqiang An, Rongfu Wang

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e004035; DOI: 10.1136/jitc-2021-004035
Dual checkpoint blockade of CD47 and PD-L1 using an affinity-tuned bispecific antibody maximizes antitumor immunity
Shih-Hsun Chen, Pawel K Dominik, Jessica Stanfield, Sheng Ding, Wenjing Yang, Nadia Kurd, Ryan Llewellyn, Jonathan Heyen, Carole Wang, Zea Melton, Thomas Van Blarcom, Kevin C Lindquist, Javier Chaparro-Riggers, Shahram Salek-Ardakani

Journal for ImmunoTherapy of Cancer Oct 2021, 9 (10) e003464; DOI: 10.1136/jitc-2021-003464
Dichotomous impact of affinity on the function of T cell engaging bispecific antibodies
Mathilde Poussin, Arlene Sereno, Xiufeng Wu, Flora Huang, Jason Manro, Shanshan Cao, Carmine Carpenito, Andrew Glasebrook, Daniel J Powell Jr, Stephen J Demarest

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002444; DOI: 10.1136/jitc-2021-002444

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