CD4-Positive T-Lymphocytes

Dual molecule targeting HDAC6 leads to intratumoral CD4+ cytotoxic lymphocytes recruitment through MHC-II upregulation on lung cancer cells
Sarah Ducellier, Mélanie Demeules, Boris Letribot, Massimiliano Gaetani, Chloé Michaudel, Harry Sokol, Abdallah Hamze, Mouad Alami, Mégane Nascimento, Sébastien Apcher

Journal for ImmunoTherapy of Cancer Apr 2024, 12 (4) e007588; DOI: 10.1136/jitc-2023-007588
mRNA vaccines against SARS-CoV-2 induce divergent antigen-specific T-cell responses in patients with lung cancer
No-Joon Song, Karthik B Chakravarthy, Hyeongseon Jeon, Chelsea Bolyard, Kelsi Reynolds, Kevin P Weller, Sarah Reisinger, Yi Wang, Anqi Li, Sizun Jiang, Qin Ma, Dan H Barouch, Mark P Rubinstein, Peter G Shields, Eugene M Oltz, Dongjun Chung, Zihai Li

Journal for ImmunoTherapy of Cancer Jan 2024, 12 (1) e007922; DOI: 10.1136/jitc-2023-007922
Th17-inducing dendritic cell vaccines stimulate effective CD4 T cell-dependent antitumor immunity in ovarian cancer that overcomes resistance to immune checkpoint blockade
Yan Luo, Barath Shreeder, James W Jenkins, Huashan Shi, Purushottam Lamichhane, Kexun Zhou, Deborah A Bahr, Sophia Kurian, Katherine A Jones, Joshua I Daum, Navnita Dutta, Brian M Necela, Martin J Cannon, Matthew S Block, Keith L Knutson

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (11) e007661; DOI: 10.1136/jitc-2023-007661
MDR1-expressing CD4⁺ T cells with Th1.17 features resist to neoadjuvant chemotherapy and are associated with breast cancer clinical response
Anthony Di Roio, Margaux Hubert, Laurie Besson, Marion Bossennec, Céline Rodriguez, Yenkel Grinberg-Bleyer, Guilhem Lalle, Lyvia Moudombi, Raphael Schneider, Cyril Degletagne, Isabelle Treilleux, Daniel J Campbell, Séverine Metzger, Thomas Duhen, Olivier Trédan, Christophe Caux, Christine Ménétrier-Caux

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (11) e007733; DOI: 10.1136/jitc-2023-007733
Effect of CD4+ T cell count on treatment-emergent adverse events among patients with and without HIV receiving immunotherapy for advanced cancer
Thomas A Odeny, Kathryn Lurain, Julius Strauss, Steven P Fling, Elad Sharon, Anna Wright, Javier Martinez-Picado, Teresa Moran, James L Gulley, Maria Gonzalez-Cao, Thomas S Uldrick, Robert Yarchoan, Ramya Ramaswami

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e005128; DOI: 10.1136/jitc-2022-005128
Nemvaleukin alfa, a novel engineered IL-2 fusion protein, drives antitumor immunity and inhibits tumor growth in small cell lung cancer
Yuanwang Pan, Yuan Hao, Han Han, Ting Chen, Hailin Ding, Kristen E Labbe, Elaine Shum, Kayla Guidry, Hai Hu, Fiona Sherman, Ke Geng, Janaye Stephens, Alison Chafitz, Sittinon Tang, Hsin-Yi Huang, Chengwei Peng, Christina Almonte, Jared E Lopes, Heather C Losey, Raymond J Winquist, Vamsidhar Velcheti, Hua Zhang, Kwok-Kin Wong

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e004913; DOI: 10.1136/jitc-2022-004913
Transcriptional and functional analyses of neoantigen-specific CD4 T cells during a profound response to anti-PD-L1 in metastatic Merkel cell carcinoma
Candice Church, Thomas Pulliam, Natalie Longino, Song Y Park, Kimberly S Smythe, Vladimir Makarov, Nadeem Riaz, Lichen Jing, Robert Amezquita, Jean S Campbell, Raphael Gottardo, Robert H Pierce, Jaehyuk Choi, Timothy A Chan, David M Koelle, Paul Nghiem

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e005328; DOI: 10.1136/jitc-2022-005328
Phase I/II clinical trial of a helper peptide vaccine plus PD-1 blockade in PD-1 antibody-naïve and PD-1 antibody-experienced patients with melanoma (MEL64)
Rick D Vavolizza, Gina R Petroni, Ileana S Mauldin, Kimberly A Chianese-Bullock, Walter C Olson, Kelly T Smith, Lynn T Dengel, Kathleen Haden, William W Grosh, Varinder Kaur, Nikole Varhegyi, Elizabeth M Gaughan, Craig L Slingluff

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e005424; DOI: 10.1136/jitc-2022-005424
T cell-intrinsic STING signaling promotes regulatory T cell induction and immunosuppression by upregulating FOXP3 transcription in cervical cancer
Huanhe Ni, Huanling Zhang, Lin Li, He Huang, Hui Guo, Lin Zhang, Chunwei Li, Jing-Xiao Xu, Cai-Ping Nie, Kui Li, Xiaoshi Zhang, Xiaojun Xia, Jiang Li

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e005151; DOI: 10.1136/jitc-2022-005151
CLN-978, a novel half-life extended CD19/CD3/HSA-specific T cell-engaging antibody construct with potent activity against B-cell malignancies with low CD19 expression
Kristan Meetze, Naveen K Mehta, Bochong Li, Hannah M Findlay, Timothy B London, Agapitos Patakas, Jennifer S Michaelson, Patrick A Baeuerle

Journal for ImmunoTherapy of Cancer Aug 2023, 11 (8) e007398; DOI: 10.1136/jitc-2023-007398

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