CD4-Positive T-Lymphocytes

Pre-existing effector T-cell levels and augmented myeloid cell composition denote response to CDK4/6 inhibitor palbociclib and pembrolizumab in hormone receptor-positive metastatic breast cancer
Colt Egelston, Weihua Guo, Susan Yost, Jin Sun Lee, David Rose, Christian Avalos, Jian Ye, Paul Frankel, Daniel Schmolze, James Waisman, Peter Lee, Yuan Yuan

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e002084; DOI: 10.1136/jitc-2020-002084
Trial to evaluate the immunogenicity and safety of a melanoma helper peptide vaccine plus incomplete Freund’s adjuvant, cyclophosphamide, and polyICLC (Mel63)
Craig L Slingluff, Jr., Gina R Petroni, Kimberly A Chianese-Bullock, Nolan A Wages, Walter C Olson, Kelly T Smith, Kathleen Haden, Lynn T Dengel, Anna Dickinson, Caroline Reed, Elizabeth M Gaughan, William W Grosh, Varinder Kaur, Nikole Varhegyi, Mark Smolkin, Nadejda V Galeassi, Donna Deacon, Emily H Hall

Journal for ImmunoTherapy of Cancer Jan 2021, 9 (1) e000934; DOI: 10.1136/jitc-2020-000934
Wrinkle in the plan: miR-34a-5p impacts chemokine signaling by modulating CXCL10/CXCL11/CXCR3-axis in CD4⁺, CD8⁺ T cells, and M1 macrophages
Martin Hart, Laura Nickl, Barbara Walch-Rueckheim, Lena Krammes, Stefanie Rheinheimer, Caroline Diener, Tanja Taenzer, Tim Kehl, Martina Sester, Hans-Peter Lenhof, Andreas Keller, Eckart Meese

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (2) e001617; DOI: 10.1136/jitc-2020-001617
Investigation of the prognostic value of CD4 T cell subsets expanded from tumor-infiltrating lymphocytes of colorectal cancer liver metastases
Marie Kroemer, Celia Turco, Laurie Spehner, Julien Viot, Idir Idirène, Adeline Bouard, Elodie Renaude, Marina Deschamps, Yann Godet, Olivier Adotévi, Samuel Limat, Bruno Heyd, Marine Jary, Romain Loyon, Christophe Borg

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (2) e001478; DOI: 10.1136/jitc-2020-001478
Neoantigen-specific CD4⁺ T-cell response is critical for the therapeutic efficacy of cryo-thermal therapy
Peng Peng, Hongming Hu, Ping Liu, Lisa X Xu

Journal for ImmunoTherapy of Cancer Sep 2020, 8 (2) e000421; DOI: 10.1136/jitc-2019-000421
Combination vaccine based on citrullinated vimentin and enolase peptides induces potent CD4-mediated anti-tumor responses
Victoria A Brentville, Rachael L Metheringham, Ian Daniels, Suha Atabani, Peter Symonds, Katherine W Cook, Mireille Vankemmelbeke, Ruhul Choudhury, Poonam Vaghela, Mohamed Gijon, Ghislaine Meiners, Willem-Jan Krebber, Cornelis J M Melief, Lindy G Durrant

Journal for ImmunoTherapy of Cancer Jun 2020, 8 (1) e000560; DOI: 10.1136/jitc-2020-000560

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