CD8-Positive T-Lymphocytes

Tryptophan potentiates CD8⁺ T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation
Rui Qin, Chen Zhao, Chen-Ji Wang, Wei Xu, Jian-Yuan Zhao, Yan Lin, Yi-Yuan Yuan, Peng-Cheng Lin, Yao Li, Shimin Zhao, Yan Huang

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002840; DOI: 10.1136/jitc-2021-002840
Statin-mediated inhibition of RAS prenylation activates ER stress to enhance the immunogenicity of KRAS mutant cancer
Gi-Hoon Nam, Minsu Kwon, Hanul Jung, Eunbyeol Ko, Seong A Kim, Yoonjeong Choi, Su Jeong Song, Seohyun Kim, Yeji Lee, Gi Beom Kim, Jihoon Han, Jiwan Woo, Yakdol Cho, Cherlhyun Jeong, Seung-Yoon Park, Thomas M. Roberts, Yong Beom Cho, In-San Kim

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002474; DOI: 10.1136/jitc-2021-002474
CXCR6 is required for antitumor efficacy of intratumoral CD8⁺ T cell
Binglin Wang, Yi Wang, Xiaofan Sun, Guoliang Deng, Wei Huang, Xingxin Wu, Yanghong Gu, Zhigang Tian, Zhimin Fan, Qiang Xu, Hongqi Chen, Yang Sun

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e003100; DOI: 10.1136/jitc-2021-003100
Sensitizing tumors to anti-PD-1 therapy by promoting NK and CD8+ T cells via pharmacological activation of FOXO3
Young Min Chung, Pragya P Khan, Hong Wang, Wen-Bin Tsai, Yanli Qiao, Bo Yu, James W Larrick, Mickey C-T Hu

Journal for ImmunoTherapy of Cancer Dec 2021, 9 (12) e002772; DOI: 10.1136/jitc-2021-002772
Combinatorial immunotherapy induces tumor-infiltrating CD8⁺ T cells with distinct functional, migratory, and stem-like properties
Natalija Van Braeckel-Budimir, Joseph Samuel Dolina, Jie Wei, Xiao Wang, Shih-Hsun Chen, Pamela Santiago, Guanghuan Tu, Luca Micci, Amir A Al-Khami, Sophia Pfister, Sripad Ram, Purnima Sundar, Graham Thomas, Hua Long, Wenjing Yang, Shobha Potluri, Shahram Salek-Ardakani

Journal for ImmunoTherapy of Cancer Dec 2021, 9 (12) e003614; DOI: 10.1136/jitc-2021-003614
Cancer stem-like cells evade CD8⁺CD103⁺ tumor-resident memory T (T_RM) lymphocytes by initiating an epithelial-to-mesenchymal transition program in a human lung tumor model
Stéphanie Corgnac, Isabelle Damei, Gwendoline Gros, Aziza Caidi, Stéphane Terry, Salem Chouaib, Marc Deloger, Fathia Mami-Chouaib

Journal for ImmunoTherapy of Cancer Apr 2022, 10 (4) e004527; DOI: 10.1136/jitc-2022-004527
Albumin and interferon-β fusion protein serves as an effective vaccine adjuvant to enhance antigen-specific CD8+ T cell-mediated antitumor immunity
Ssu-Hsueh Tseng, Max A Cheng, Emily Farmer, Louise Ferrall, Yu Jui Kung, Brandon Lam, Ling Lim, T-C Wu, Chien-Fu Hung

Journal for ImmunoTherapy of Cancer Apr 2022, 10 (4) e004342; DOI: 10.1136/jitc-2021-004342
Patients with HIV-associated cancers have evidence of increased T cell dysfunction and exhaustion prior to cancer diagnosis
Omkar Chaudhary, Diane Trotta, Kaicheng Wang, Xun Wang, Xiuping Chu, Chip Bradley, Jason Okulicz, Ryan C Maves, Karl Kronmann, Christina M Schofield, Jason M Blaylock, Yanhong Deng, Kurt A Schalper, Susan M Kaech, Brian Agan, Anuradha Ganesan, Brinda Emu

Journal for ImmunoTherapy of Cancer Apr 2022, 10 (4) e004564; DOI: 10.1136/jitc-2022-004564
Characterization of the treatment-naive immune microenvironment in melanoma with BRAF mutation
Minyu Wang, Soroor Zadeh, Angela Pizzolla, Kevin Thia, David E Gyorki, Grant A McArthur, Richard A Scolyer, Georgina Long, James S Wilmott, Miles C Andrews, George Au-Yeung, Ali Weppler, Shahneen Sandhu, Joseph A Trapani, Melissa J Davis, Paul Joseph Neeson

Journal for ImmunoTherapy of Cancer Apr 2022, 10 (4) e004095; DOI: 10.1136/jitc-2021-004095
Type 17 immunity promotes the exhaustion of CD8⁺ T cells in cancer
Byung-Seok Kim, Da-Sol Kuen, Choong-Hyun Koh, Hyung-Don Kim, Seon Hee Chang, Sehui Kim, Yoon Kyung Jeon, Young-Jun Park, Garam Choi, Jiyeon Kim, Keon Wook Kang, Hye Young Kim, Suk-Jo Kang, Shin Hwang, Eui-Cheol Shin, Chang-Yuil Kang, Chen Dong, Yeonseok Chung

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002603; DOI: 10.1136/jitc-2021-002603

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