CD8+ T cells

First-in-human phase 1 study of IT1208, a defucosylated humanized anti-CD4 depleting antibody, in patients with advanced solid tumors
Kohei Shitara, Satoshi Ueha, Shigeyuki Shichino, Hiroyasu Aoki, Haru Ogiwara, Tetsuya Nakatsura, Toshihiro Suzuki, Manami Shimomura, Toshiaki Yoshikawa, Kayoko Shoda, Shigehisa Kitano, Makiko Yamashita, Takayuki Nakayama, Akihiro Sato, Sakiko Kuroda, Masashi Wakabayashi, Shogo Nomura, Shoji Yokochi, Satoru Ito, Kouji Matsushima, Toshihiko Doi

Journal for ImmunoTherapy of Cancer Dec 2019, 7 (1) 195; DOI: 10.1186/s40425-019-0677-y
PD1^Hi CD8⁺ T cells correlate with exhausted signature and poor clinical outcome in hepatocellular carcinoma
Jiaqiang Ma, Bohao Zheng, Shyamal Goswami, Lu Meng, Dandan Zhang, Chunmei Cao, Teng Li, Fangming Zhu, Lijie Ma, Zhao Zhang, Shuhao Zhang, Meng Duan, Qin Chen, Qiang Gao, Xiaoming Zhang

Journal for ImmunoTherapy of Cancer Dec 2019, 7 (1) 331; DOI: 10.1186/s40425-019-0814-7
Cancer-cell-secreted CXCL11 promoted CD8⁺ T cells infiltration through docetaxel-induced-release of HMGB1 in NSCLC
Qun Gao, Shumin Wang, Xinfeng Chen, Shaoyan Cheng, Zhen Zhang, Feng Li, Lan Huang, Yang Yang, Bin Zhou, Dongli Yue, Dan Wang, Ling Cao, Nomathamsanqa Resegofetse Maimela, Bin Zhang, Jane Yu, Liping Wang, Yi Zhang

Journal for ImmunoTherapy of Cancer Dec 2019, 7 (1) 42; DOI: 10.1186/s40425-019-0511-6
Targeting interferon signaling and CTLA-4 enhance the therapeutic efficacy of anti-PD-1 immunotherapy in preclinical model of HPV⁺ oral cancer
Stephanie Dorta-Estremera, Venkatesh L. Hegde, Ravaen B. Slay, Rachel Sun, Ananta V. Yanamandra, Courtney Nicholas, Sita Nookala, Gloria Sierra, Michael A. Curran, K. Jagannadha Sastry

Journal for ImmunoTherapy of Cancer Dec 2019, 7 (1) 252; DOI: 10.1186/s40425-019-0728-4
NK cells and CD8+ T cells cooperate to improve therapeutic responses in melanoma treated with interleukin-2 (IL-2) and CTLA-4 blockade
Frederick J Kohlhapp, Joseph R Broucek, Tasha Hughes, Erica J Huelsmann, Jevgenijs Lusciks, Janet P Zayas, Hubert Dolubizno, Vidyaratna A Fleetwood, Alisa Grin, Graham E Hill, Joseph L Poshepny, Arman Nabatiyan, Carl E Ruby, Joshua D Snook, Jai S Rudra, Jason M Schenkel, David Masopust, Andrew Zloza, Howard L Kaufman

Journal for ImmunoTherapy of Cancer Dec 2015, 3 (1) 18; DOI: 10.1186/s40425-015-0063-3

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CD8+ T cells