cell engineering

Large-scale manufacturing and characterization of CMV-CD19CAR T cells
Xiuli Wang, Ryan Urak, Miriam Walter, Min Guan, Tianxu Han, Vibhuti Vyas, Sheng-Hsuan Chien, Brenna Gittins, Mary C Clark, Sally Mokhtari, Angelo Cardoso, Don J Diamond, John Zaia, Stephen J Forman, Ryotaro Nakamura

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003461; DOI: 10.1136/jitc-2021-003461
Targeting disialoganglioside GD2 with chimeric antigen receptor-redirected T cells in lung cancer
Loïc Reppel, Ourania Tsahouridis, Jason Akulian, Ian J Davis, Hong Lee, Giovanni Fucà, Jared Weiss, Gianpietro Dotti, Chad V Pecot, Barbara Savoldo

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003897; DOI: 10.1136/jitc-2021-003897
CD70 as an actionable immunotherapeutic target in recurrent glioblastoma and its microenvironment
Mathieu Seyfrid, William Thomas Maich, Vaseem Muhammad Shaikh, Nazanin Tatari, Deepak Upreti, Deween Piyasena, Minomi Subapanditha, Neil Savage, Dillon McKenna, Nicholas Mikolajewicz, Hong Han, Chirayu Chokshi, Laura Kuhlmann, Amanda Khoo, Sabra Khalid Salim, Blessing Archibong-Bassey, William Gwynne, Kevin Brown, Nadeem Murtaza, David Bakhshinyan, Parvez Vora, Chitra Venugopal, Jason Moffat, Thomas Kislinger, Sheila Singh

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003289; DOI: 10.1136/jitc-2021-003289
Off-the-shelf Vδ1 gamma delta T cells engineered with glypican-3 (GPC-3)-specific chimeric antigen receptor (CAR) and soluble IL-15 display robust antitumor efficacy against hepatocellular carcinoma
Amani Makkouk, Xue (Cher) Yang, Taylor Barca, Anthony Lucas, Mustafa Turkoz, Jonathan T S Wong, Kevin P Nishimoto, Mary M Brodey, Maryam Tabrizizad, Smitha R Y Gundurao, Lu Bai, Arun Bhat, Zili An, Stewart Abbot, Daulet Satpayev, Blake T Aftab, Marissa Herrman

Journal for ImmunoTherapy of Cancer Dec 2021, 9 (12) e003441; DOI: 10.1136/jitc-2021-003441
Factors associated with the clinical outcome of patients with relapsed/refractory CD19⁺ acute lymphoblastic leukemia treated with ARI-0001 CART19-cell therapy
Valentín Ortiz-Maldonado, Susana Rives, Marta Español-Rego, Anna Alonso-Saladrigues, Mercedes Montoro, Laura Magnano, Eva Giné, Mariona Pascal, Marina Díaz-Beyá, Maria Castella, Albert Català, Anna Faura, Luis Gerardo Rodríguez-Lobato, Aina Oliver-Caldes, Alexandra Martínez-Roca, Montserrat Rovira, E Azucena González-Navarro, Juan Ramón Ortega, Joan Cid, Miquel Lozano, Enric Garcia-Rey, Sara Fernández, Pedro Castro, Iolanda Jordan, Neus Villamor, Marta Aymerich, Montserrat Torrebadell, Àngela Deyà, Carlos Fernández de Larrea, Daniel Benitez-Ribas, Esteve Trias, Sara Varea, Gonzalo Calvo, Jordi Esteve, Alvaro Urbano-Ispizua, Manel Juan, Julio Delgado

Journal for ImmunoTherapy of Cancer Dec 2021, 9 (12) e003644; DOI: 10.1136/jitc-2021-003644
Engineering CAR-NK cells to secrete IL-15 sustains their anti-AML functionality but is associated with systemic toxicities
Ilias Christodoulou, Won Jin Ho, Andrew Marple, Jonas W Ravich, Ada Tam, Ruyan Rahnama, Adam Fearnow, Cambrynne Rietberg, Sean Yanik, Elena E Solomou, Ravi Varadhan, Michael A Koldobskiy, Challice L Bonifant

Journal for ImmunoTherapy of Cancer Dec 2021, 9 (12) e003894; DOI: 10.1136/jitc-2021-003894
4-1BB and optimized CD28 co-stimulation enhances function of human mono-specific and bi-specific third-generation CAR T cells
Emiliano Roselli, Justin C Boucher, Gongbo Li, Hiroshi Kotani, Kristen Spitler, Kayla Reid, Estelle V Cervantes, Yannick Bulliard, Nhan Tu, Sae Bom Lee, Bin Yu, Frederick L Locke, Marco L Davila

Journal for ImmunoTherapy of Cancer Oct 2021, 9 (10) e003354; DOI: 10.1136/jitc-2021-003354
Conditioned CAR-T cells by hypoxia-inducible transcription amplification (HiTA) system significantly enhances systemic safety and retains antitumor efficacy
Huan He, Qibin Liao, Chen Zhao, Cuisong Zhu, Meiqi Feng, Zhuoqun Liu, Lang Jiang, Linxia Zhang, Xiangqing Ding, Min Yuan, Xiaoyan Zhang, Jianqing Xu

Journal for ImmunoTherapy of Cancer Oct 2021, 9 (10) e002755; DOI: 10.1136/jitc-2021-002755
Bispecific binder redirected lentiviral vector enables in vivo engineering of CAR-T cells
Justin T Huckaby, Elisa Landoni, Timothy M Jacobs, Barbara Savoldo, Gianpietro Dotti, Samuel K Lai

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002737; DOI: 10.1136/jitc-2021-002737
CARs and beyond: tailoring macrophage-based cell therapeutics to combat solid malignancies
Shifaa M. Abdin, Daniela Paasch, Michael Morgan, Nico Lachmann

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e002741; DOI: 10.1136/jitc-2021-002741

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