cell engineering

Both APRIL and antibody-fragment-based CAR T cells for myeloma induce BCMA downmodulation by trogocytosis and internalization
Nicolas Camviel, Benita Wolf, Giancarlo Croce, David Gfeller, Vincent Zoete, Caroline Arber

Journal for ImmunoTherapy of Cancer Nov 2022, 10 (11) e005091; DOI: 10.1136/jitc-2022-005091
Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors
Jessica B Foster, Crystal Griffin, Jo Lynne Rokita, Allison Stern, Cameron Brimley, Komal Rathi, Maria V Lane, Samantha N Buongervino, Tiffany Smith, Peter J Madsen, Daniel Martinez, Alberto Delaidelli, Poul H Sorensen, Robert J Wechsler-Reya, Katalin Karikó, Phillip B Storm, David M Barrett, Adam C Resnick, John M Maris, Kristopher R Bosse

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e004450; DOI: 10.1136/jitc-2021-004450
Automated, scaled, transposon-based production of CAR T cells
Dominik Lock, Razieh Monjezi, Caroline Brandes, Stephan Bates, Simon Lennartz, Karin Teppert, Leon Gehrke, Rafailla Karasakalidou-Seidt, Teodora Lukic, Marco Schmeer, Martin Schleef, Niels Werchau, Matthias Eyrich, Mario Assenmacher, Andrew Kaiser, Sabrina Prommersberger, Thomas Schaser, Michael Hudecek

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e005189; DOI: 10.1136/jitc-2022-005189
Production and characterization of virus-free, CRISPR-CAR T cells capable of inducing solid tumor regression
Katherine P Mueller, Nicole J Piscopo, Matthew H Forsberg, Louise A Saraspe, Amritava Das, Brittany Russell, Madeline Smerchansky, Dan Cappabianca, Lei Shi, Keerthana Shankar, Lauren Sarko, Namita Khajanchi, Nina La Vonne Denne, Apoorva Ramamurthy, Adeela Ali, Cicera R Lazzarotto, Shengdar Q Tsai, Christian M Capitini, Krishanu Saha

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e004446; DOI: 10.1136/jitc-2021-004446
Targeting the extra domain A of fibronectin for cancer therapy with CAR-T cells
Celia Martín-Otal, Aritz Lasarte-Cia, Diego Serrano, Noelia Casares, Enrique Conde, Flor Navarro, Inés Sánchez-Moreno, Marta Gorraiz, Patricia Sarrión, Alfonso Calvo, Carlos E De Andrea, José Echeveste, Amaia Vilas, Juan Roberto Rodriguez-Madoz, Jesús San Miguel, Felipe Prosper, Sandra Hervas-Stubbs, Juan Jose Lasarte, Teresa Lozano

Journal for ImmunoTherapy of Cancer Aug 2022, 10 (8) e004479; DOI: 10.1136/jitc-2021-004479
CRISPR-mediated TGFBR2 knockout renders human ovarian cancer tumor-infiltrating lymphocytes resistant to TGF-β signaling
Samantha M Fix, Marie-Andrée Forget, Donastas Sakellariou-Thompson, Yunfei Wang, Tamara M Griffiths, Minjung Lee, Cara L Haymaker, Ana Lucía Dominguez, Rafet Basar, Christopher Reyes, Sanjay Kumar, Larissa A Meyer, Patrick Hwu, Chantale Bernatchez, Amir A Jazaeri

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e003750; DOI: 10.1136/jitc-2021-003750
Indomethacin-induced oxidative stress enhances death receptor 5 signaling and sensitizes tumor cells to adoptive T-cell therapy
Nada S Aboelella, Caitlin Brandle, Ogacheko Okoko, Md Yeashin Gazi, Zhi-Chun Ding, Hongyan Xu, Gregory Gorman, Roni Bollag, Marco L Davila, Locke J Bryan, David H Munn, Gary A Piazza, Gang Zhou

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004938; DOI: 10.1136/jitc-2022-004938
NIR fluorescence imaging and treatment for cancer immunotherapy
Homan Kang, Min-Woong Kang, Satoshi Kashiwagi, Hak Soo Choi

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004936; DOI: 10.1136/jitc-2022-004936
Structural insights into engineering a T-cell receptor targeting MAGE-A10 with higher affinity and specificity for cancer immunotherapy
Philip C Simister, Ellen C Border, João F Vieira, Nicholas J Pumphrey

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004600; DOI: 10.1136/jitc-2022-004600
NY-ESO-1-specific redirected T cells with endogenous TCR knockdown mediate tumor response and cytokine release syndrome
Mikiya Ishihara, Shigehisa Kitano, Shinichi Kageyama, Yoshihiro Miyahara, Noboru Yamamoto, Hidefumi Kato, Hideyuki Mishima, Hiroyoshi Hattori, Takeru Funakoshi, Takashi Kojima, Tetsuro Sasada, Eiichi Sato, Sachiko Okamoto, Daisuke Tomura, Ikuei Nukaya, Hideto Chono, Junichi Mineno, Muhammad Faris Kairi, Phuong Diem Hoang Nguyen, Yannick Simoni, Alessandra Nardin, Evan Newell, Michael Fehlings, Hiroaki Ikeda, Takashi Watanabe, Hiroshi Shiku

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e003811; DOI: 10.1136/jitc-2021-003811

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