cell engineering

Targeting the extra domain A of fibronectin for cancer therapy with CAR-T cells
Celia Martín-Otal, Aritz Lasarte-Cia, Diego Serrano, Noelia Casares, Enrique Conde, Flor Navarro, Inés Sánchez-Moreno, Marta Gorraiz, Patricia Sarrión, Alfonso Calvo, Carlos E De Andrea, José Echeveste, Amaia Vilas, Juan Roberto Rodriguez-Madoz, Jesús San Miguel, Felipe Prosper, Sandra Hervas-Stubbs, Juan Jose Lasarte, Teresa Lozano

Journal for ImmunoTherapy of Cancer Aug 2022, 10 (8) e004479; DOI: 10.1136/jitc-2021-004479
Indomethacin-induced oxidative stress enhances death receptor 5 signaling and sensitizes tumor cells to adoptive T-cell therapy
Nada S Aboelella, Caitlin Brandle, Ogacheko Okoko, Md Yeashin Gazi, Zhi-Chun Ding, Hongyan Xu, Gregory Gorman, Roni Bollag, Marco L Davila, Locke J Bryan, David H Munn, Gary A Piazza, Gang Zhou

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004938; DOI: 10.1136/jitc-2022-004938
CRISPR-mediated TGFBR2 knockout renders human ovarian cancer tumor-infiltrating lymphocytes resistant to TGF-β signaling
Samantha M Fix, Marie-Andrée Forget, Donastas Sakellariou-Thompson, Yunfei Wang, Tamara M Griffiths, Minjung Lee, Cara L Haymaker, Ana Lucía Dominguez, Rafet Basar, Christopher Reyes, Sanjay Kumar, Larissa A Meyer, Patrick Hwu, Chantale Bernatchez, Amir A Jazaeri

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e003750; DOI: 10.1136/jitc-2021-003750
NIR fluorescence imaging and treatment for cancer immunotherapy
Homan Kang, Min-Woong Kang, Satoshi Kashiwagi, Hak Soo Choi

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004936; DOI: 10.1136/jitc-2022-004936
Structural insights into engineering a T-cell receptor targeting MAGE-A10 with higher affinity and specificity for cancer immunotherapy
Philip C Simister, Ellen C Border, João F Vieira, Nicholas J Pumphrey

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004600; DOI: 10.1136/jitc-2022-004600
NY-ESO-1-specific redirected T cells with endogenous TCR knockdown mediate tumor response and cytokine release syndrome
Mikiya Ishihara, Shigehisa Kitano, Shinichi Kageyama, Yoshihiro Miyahara, Noboru Yamamoto, Hidefumi Kato, Hideyuki Mishima, Hiroyoshi Hattori, Takeru Funakoshi, Takashi Kojima, Tetsuro Sasada, Eiichi Sato, Sachiko Okamoto, Daisuke Tomura, Ikuei Nukaya, Hideto Chono, Junichi Mineno, Muhammad Faris Kairi, Phuong Diem Hoang Nguyen, Yannick Simoni, Alessandra Nardin, Evan Newell, Michael Fehlings, Hiroaki Ikeda, Takashi Watanabe, Hiroshi Shiku

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e003811; DOI: 10.1136/jitc-2021-003811
Development of anti-somatostatin receptors CAR T cells for treatment of neuroendocrine tumors
Barbara Mandriani, Eleonora Pellè, Francesco Mannavola, Antonio Palazzo, Renè Massimiliano Marsano, Giuseppe Ingravallo, Gerardo Cazzato, Maria Cecilia Ramello, Camillo Porta, Jonathan Strosberg, Daniel Abate-Daga, Mauro Cives

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004854; DOI: 10.1136/jitc-2022-004854
Antibody-based redirection of universal Fabrack-CAR T cells selectively kill antigen bearing tumor cells
Yi-Chiu Kuo, Cheng-Fu Kuo, Kurt Jenkins, Alfur Fu-Hsin Hung, Wen-Chung Chang, Miso Park, Brenda Aguilar, Renate Starr, Jonathan Hibbard, Christine Brown, John C Williams

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e003752; DOI: 10.1136/jitc-2021-003752
Hypoxia-inducible lentiviral gene expression in engineered human macrophages
Harrison K Chinn, Jennifer L Gardell, Lisa R Matsumoto, Kevin P Labadie, Tara N Mihailovic, Nicole A P Lieberman, Amira Davis, Venu G Pillarisetty, Courtney A Crane

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e003770; DOI: 10.1136/jitc-2021-003770
Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity
Pierre-Louis Bernard, Rebecca Delconte, Sonia Pastor, Vladimir Laletin, Cathy Costa Da Silva, Armelle Goubard, Emmanuelle Josselin, Rémy Castellano, Adrien Krug, Julien Vernerey, Raynier Devillier, Daniel Olive, Els Verhoeyen, Eric Vivier, Nicholas D Huntington, Jacques Nunes, Geoffrey Guittard

Journal for ImmunoTherapy of Cancer May 2022, 10 (5) e004244; DOI: 10.1136/jitc-2021-004244

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