cell engineering

Bispecific binder redirected lentiviral vector enables in vivo engineering of CAR-T cells
Justin T Huckaby, Elisa Landoni, Timothy M Jacobs, Barbara Savoldo, Gianpietro Dotti, Samuel K Lai

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002737; DOI: 10.1136/jitc-2021-002737
CARs and beyond: tailoring macrophage-based cell therapeutics to combat solid malignancies
Shifaa M. Abdin, Daniela Paasch, Michael Morgan, Nico Lachmann

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e002741; DOI: 10.1136/jitc-2021-002741
VEGFR-2 redirected CAR-T cells are functionally impaired by soluble VEGF-A competition for receptor binding
Evripidis Lanitis, Paris Kosti, Catherine Ronet, Elisabetta Cribioli, Giorgia Rota, Aodrenn Spill, Patrick Reichenbach, Vincent Zoete, Denarda Dangaj Laniti, George Coukos, Melita Irving

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e002151; DOI: 10.1136/jitc-2020-002151
Chimeric non-antigen receptors in T cell-based cancer therapy
Jitao Guo, Andrew Kent, Eduardo Davila

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e002628; DOI: 10.1136/jitc-2021-002628
High-affinity T-cell receptor specific for MyD88 L265P mutation for adoptive T-cell therapy of B-cell malignancies
Özcan Çınar, Bernadette Brzezicha, Corinna Grunert, Peter Michael Kloetzel, Christin Beier, Caroline Anna Peuker, Ulrich Keller, Antonio Pezzutto, Antonia Busse

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002410; DOI: 10.1136/jitc-2021-002410
Direct identification of neoantigen-specific TCRs from tumor specimens by high-throughput single-cell sequencing
Yong-Chen Lu, Zhili Zheng, Frank J Lowery, Jared J Gartner, Todd D Prickett, Paul F Robbins, Steven A Rosenberg

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002595; DOI: 10.1136/jitc-2021-002595
Strategy to prevent epitope masking in CAR.CD19+ B-cell leukemia blasts
Concetta Quintarelli, Marika Guercio, Simona Manni, Iolanda Boffa, Matilde Sinibaldi, Stefano Di Cecca, Simona Caruso, Zeinab Abbaszadeh, Antonio Camera, Biancamaria Cembrola, Roselia Ciccone, Alberto Orfao, Lourdes Martin-Martin, Sara Gutierrez-Herrero, Maria Herrero-Garcia, Gianni Cazzaniga, Vittorio Nunes, Simona Songia, Paolo Marcatili, Frederikke I Marin, Marco Ruella, Valentina Bertaina, Luciana Vinti, Francesca Del Bufalo, Mattia Algeri, Pietro Merli, Biagio De Angelis, Franco Locatelli

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e001514; DOI: 10.1136/jitc-2020-001514
Phase II clinical trial using anti-CD3 × anti-HER2 bispecific antibody armed activated T cells (HER2 BATs) consolidation therapy for HER2 negative (0–2+) metastatic breast cancer
Lawrence G. Lum, Zaid Al-Kadhimi, Abhinav Deol, Vidya Kondadasula, Dana Schalk, Elyse Tomashewski, Patricia Steele, Kristie Fields, Melissa Giroux, Qin Liu, Lawrence Flaherty, Michael Simon, Archana Thakur

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002194; DOI: 10.1136/jitc-2020-002194
Δ133p53α enhances metabolic and cellular fitness of TCR-engineered T cells and promotes superior antitumor immunity
Kevin Jan Legscha, Edite Antunes Ferreira, Antonios Chamoun, Alexander Lang, Mohamed Hemaid Sayed Awwad, Gigi Nu Hoang Quy Ton, Danuta Galetzka, Borhane Guezguez, Michael Hundemer, Jean-Christophe Bourdon, Markus Munder, Matthias Theobald, Hakim Echchannaoui

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e001846; DOI: 10.1136/jitc-2020-001846
IL-15 mediated expansion of rare durable memory T cells following adoptive cellular therapy
Karan Kohli, Lu Yao, Theodore Scott Nowicki, Shihong Zhang, Ralph Graeme Black, Brett A Schroeder, Erik A Farrar, Jianhong Cao, Heather Sloan, Dawn Stief, Lee D Cranmer, Michael J Wagner, Douglas S Hawkins, Venu G Pillarisetty, Antoni Ribas, Jean Campbell, Robert H Pierce, Edward Y Kim, Robin L Jones, Stanley R Riddell, Cassian Yee, Seth M Pollack

Journal for ImmunoTherapy of Cancer May 2021, 9 (5) e002232; DOI: 10.1136/jitc-2020-002232

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