Clinical trials

Efficacy of pembrolizumab in patients with pituitary carcinoma: report of four cases from a phase II study
Nazanin Majd, Steven G Waguespack, Filip Janku, Siqing Fu, Marta Penas-Prado, Mingxuan Xu, Anas Alshawa, Carlos Kamiya-Matsuoka, Shaan M Raza, Ian E McCutcheon, Aung Naing

Journal for ImmunoTherapy of Cancer Dec 2020, 8 (2) e001532; DOI: 10.1136/jitc-2020-001532
Durvalumab and tremelimumab with or without stereotactic body radiation therapy in relapsed small cell lung cancer: a randomized phase II study
Suchita Pakkala, Kristin Higgins, Zhengjia Chen, Gabriel Sica, Conor Steuer, Chao Zhang, Guojing Zhang, Shuhua Wang, Mohammad S Hossain, Bassel Nazha, Tyler Beardslee, Fadlo R Khuri, Walter Curran, Sagar Lonial, Edmund K Waller, Suresh Ramalingam, Taofeek K Owonikoko

Journal for ImmunoTherapy of Cancer Dec 2020, 8 (2) e001302; DOI: 10.1136/jitc-2020-001302
Camrelizumab plus gemcitabine and oxaliplatin (GEMOX) in patients with advanced biliary tract cancer: a single-arm, open-label, phase II trial
Xiaofeng Chen, Xiaofeng Wu, Hao Wu, Yanhong Gu, Yang Shao, Qianwen Shao, Feipeng Zhu, Xiao Li, Xiaofeng Qian, Jun Hu, Fengjiao Zhao, Weidong Mao, Jing Sun, Jian Wang, Gaohua Han, Changxian Li, Yongxiang Xia, Poshita Kumari Seesaha, Dongqin Zhu, Huajun Li, Junling Zhang, Guoqiang Wang, Xuehao Wang, Xiangcheng Li, Yongqian Shu

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (2) e001240; DOI: 10.1136/jitc-2020-001240
Axitinib plus avelumab in the treatment of recurrent glioblastoma: a stratified, open-label, single-center phase 2 clinical trial (GliAvAx)
Gil Awada, Laila Ben Salama, Jennifer De Cremer, Julia Katharina Schwarze, Lydia Fischbuch, Laura Seynaeve, Stephanie Du Four, Anne-Marie Vanbinst, Alex Michotte, Hendrik Everaert, Anne Rogiers, Peter Theuns, Johnny Duerinck, Bart Neyns

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e001146; DOI: 10.1136/jitc-2020-001146
HX008, an anti-PD1 antibody, plus irinotecan as second-line treatment for advanced gastric or gastroesophageal junction cancer: a multicenter, single-arm phase II trial
Yan Song, Ning Li, Qun Li, Xinjun Liang, Shu Zhang, Qingxia Fan, Xianli Yin, Zhixiang Zhuang, Yunpeng Liu, Jingdong Zhang, Xiaoge Kou, Haijun Zhong, Xiaofei Wang, Yiwei Dou, Jing Huang

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e001279; DOI: 10.1136/jitc-2020-001279
Safety and efficacy of single cycle induction treatment with cisplatin/docetaxel/ durvalumab/tremelimumab in locally advanced HNSCC: first results of CheckRad-CD8
Markus Hecht, Antoniu Oreste Gostian, Markus Eckstein, Sandra Rutzner, Jens von der Grün, Thomas Illmer, Matthias G Hautmann, Gunther Klautke, Simon Laban, Thomas Brunner, Axel Hinke, Ina Becker, Benjamin Frey, Sabine Semrau, Carol I Geppert, Arndt Hartmann, Panagiotis Balermpas, Wilfried Budach, Udo S Gaipl, Heinrich Iro, Rainer Fietkau

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e001378; DOI: 10.1136/jitc-2020-001378
CDK4/6 inhibition enhances antitumor efficacy of chemotherapy and immune checkpoint inhibitor combinations in preclinical models and enhances T-cell activation in patients with SCLC receiving chemotherapy
Anne Y Lai, Jessica A Sorrentino, Konstantin H Dragnev, Jared M Weiss, Taofeek K Owonikoko, Julie A Rytlewski, Jill Hood, Zhao Yang, Rajesh K Malik, Jay C Strum, Patrick J Roberts

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e000847; DOI: 10.1136/jitc-2020-000847
Comparative analysis of the phase III clinical trials of anti-PD1 monotherapy in head and neck squamous cell carcinoma patients (CheckMate 141 and KEYNOTE 040)
Sara I. Pai, Sandrine Faivre, Lisa Licitra, Jean-Pascal Machiels, Jan B. Vermorken, Paolo Bruzzi, Viktor Gruenwald, Raul E. Giglio, C. René Leemans, Tanguy Y. Seiwert, Denis Soulieres

Journal for ImmunoTherapy of Cancer Dec 2019, 7 (1) 96; DOI: 10.1186/s40425-019-0578-0
A phase 1 dose escalation study of the oncolytic adenovirus enadenotucirev, administered intravenously to patients with epithelial solid tumors (EVOLVE)
Jean-Pascal Machiels, Ramon Salazar, Sylvie Rottey, Ignacio Duran, Luc Dirix, Karen Geboes, Christine Wilkinson-Blanc, Gillian Pover, Simon Alvis, Brian Champion, Kerry Fisher, Hilary McElwaine-Johnn, John Beadle, Emiliano Calvo

Journal for ImmunoTherapy of Cancer Dec 2019, 7 (1) 20; DOI: 10.1186/s40425-019-0510-7
Design considerations for early-phase clinical trials of immune-oncology agents
Nolan A. Wages, Cody Chiuzan, Katherine S. Panageas

Journal for ImmunoTherapy of Cancer Dec 2018, 6 (1) 81; DOI: 10.1186/s40425-018-0389-8

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