Dendritic cells

The tumor-targeted CD40 agonist CEA-CD40 promotes T cell priming via a dual mode of action by increasing antigen delivery to dendritic cells and enhancing their activation
Eva Sum, Moritz Rapp, Harald Dürr, Alekhya Mazumdar, Pedro J Romero, Christine Trumpfheller, Pablo Umaña

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e003264; DOI: 10.1136/jitc-2021-003264
Loss of YTHDF1 in gastric tumors restores sensitivity to antitumor immunity by recruiting mature dendritic cells
Xiaowu Bai, Chi Chun Wong, Yasi Pan, Huarong Chen, Weixin Liu, Jianning Zhai, Wei Kang, Yu Shi, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Philip Chiu, Jun Yu, Enders Kwok-wai Ng

Journal for ImmunoTherapy of Cancer Feb 2022, 10 (2) e003663; DOI: 10.1136/jitc-2021-003663
Generation of cDC-like cells from human induced pluripotent stem cells via Notch signaling
Kenichi Makino, Mark D Long, Ryutaro Kajihara, Satoko Matsueda, Takaaki Oba, Kazunori Kanehira, Song Liu, Fumito Ito

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003827; DOI: 10.1136/jitc-2021-003827
CD40L-armed oncolytic herpes simplex virus suppresses pancreatic ductal adenocarcinoma by facilitating the tumor microenvironment favorable to cytotoxic T cell response in the syngeneic mouse model
Ruikun Wang, Jingru Chen, Wei Wang, Zhuoqian Zhao, Haoran Wang, Shiyu Liu, Fan Li, Yajuan Wan, Jie Yin, Rui Wang, Yuanke Li, Cuizhu Zhang, Hongkai Zhang, Youjia Cao

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003809; DOI: 10.1136/jitc-2021-003809
Cell membrane-anchored and tumor-targeted IL-12 (attIL12)-T cell therapy for eliminating large and heterogeneous solid tumors
Jiemiao Hu, Qing Yang, Wendong Zhang, Hongwei Du, Yuhui Chen, Qingnan Zhao, Long Dao, Xueqing Xia, Fowlkes Natalie Wall, Zhongting Zhang, Kris Mahadeo, Richard Gorlick, S Kopetz, Gianpietro Dotti, Shulin Li

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003633; DOI: 10.1136/jitc-2021-003633
Safety and efficacy of dendritic cell-based immunotherapy DCVAC/OvCa added to first-line chemotherapy (carboplatin plus paclitaxel) for epithelial ovarian cancer: a phase 2, open-label, multicenter, randomized trial
Lukas Rob, David Cibula, Pawel Knapp, Peter Mallmann, Jaroslav Klat, Lubos Minar, Pavel Bartos, Josef Chovanec, Petr Valha, Marek Pluta, Zdenek Novotny, Jiri Spacek, Bohuslav Melichar, Dariusz Kieszko, Jitka Fucikova, Tereza Hrnciarova, Roman Pawel Korolkiewicz, Marek Hraska, Jirina Bartunkova, Radek Spisek

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003190; DOI: 10.1136/jitc-2021-003190
TIM-3 blockade enhances IL-12-dependent antitumor immunity by promoting CD8⁺ T cell and XCR1⁺ dendritic cell spatial co-localization
Alycia Gardner, Álvaro de Mingo Pulido, Kay Hänggi, Sarah Bazargan, Alexis Onimus, Agnieszka Kasprzak, Jose R Conejo-Garcia, Katarzyna A Rejniak, Brian Ruffell

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003571; DOI: 10.1136/jitc-2021-003571
Intratumoral co-injection of the poly I:C-derivative BO-112 and a STING agonist synergize to achieve local and distant anti-tumor efficacy
Maite Alvarez, Carmen Molina, Carlos E De Andrea, Myriam Fernandez-Sendin, Maria Villalba, Jose Gonzalez-Gomariz, Maria Carmen Ochoa, Alvaro Teijeira, Javier Glez-Vaz, Fernando Aranda, Miguel F Sanmamed, Maria E Rodriguez-Ruiz, Xinyi Fan, Wen H Shen, Pedro Berraondo, Marisol Quintero, Ignacio Melero

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e002953; DOI: 10.1136/jitc-2021-002953
Dendritic cell vaccines targeting tumor blood vessel antigens in combination with dasatinib induce therapeutic immune responses in patients with checkpoint-refractory advanced melanoma
Walter J Storkus, Deena Maurer, Yan Lin, Fei Ding, Anamika Bose, Devin Lowe, Amy Rose, Melissa DeMark, Lilit Karapetyan, Jennifer L Taylor, Manoj Chelvanambi, Ronald J Fecek, Jessica N Filderman, Timothy J Looney, Lauren Miller, Elizabeth Linch, Geoffrey M Lowman, Pawel Kalinski, Lisa H Butterfield, Ahmad Tarhini, Hussein Tawbi, John M Kirkwood

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e003675; DOI: 10.1136/jitc-2021-003675
Immune landscape in vulvar cancer-draining lymph nodes indicates distinct immune escape mechanisms in support of metastatic spread and growth
Anne Marijne Heeren, Jossie Rotman, Sanne Samuels, Henry J M A A Zijlmans, Guus Fons, Koen K van de Vijver, Maaike C G Bleeker, Gemma G Kenter, Ekaterina J Jordanova, Tanja D de Gruijl

Journal for ImmunoTherapy of Cancer Oct 2021, 9 (10) e003623; DOI: 10.1136/jitc-2021-003623

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