Dendritic cells

Generation of cDC-like cells from human induced pluripotent stem cells via Notch signaling
Kenichi Makino, Mark D Long, Ryutaro Kajihara, Satoko Matsueda, Takaaki Oba, Kazunori Kanehira, Song Liu, Fumito Ito

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003827; DOI: 10.1136/jitc-2021-003827
Safety and efficacy of dendritic cell-based immunotherapy DCVAC/OvCa added to first-line chemotherapy (carboplatin plus paclitaxel) for epithelial ovarian cancer: a phase 2, open-label, multicenter, randomized trial
Lukas Rob, David Cibula, Pawel Knapp, Peter Mallmann, Jaroslav Klat, Lubos Minar, Pavel Bartos, Josef Chovanec, Petr Valha, Marek Pluta, Zdenek Novotny, Jiri Spacek, Bohuslav Melichar, Dariusz Kieszko, Jitka Fucikova, Tereza Hrnciarova, Roman Pawel Korolkiewicz, Marek Hraska, Jirina Bartunkova, Radek Spisek

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003190; DOI: 10.1136/jitc-2021-003190
The tumor-targeted CD40 agonist CEA-CD40 promotes T cell priming via a dual mode of action by increasing antigen delivery to dendritic cells and enhancing their activation
Eva Sum, Moritz Rapp, Harald Dürr, Alekhya Mazumdar, Pedro J Romero, Christine Trumpfheller, Pablo Umaña

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e003264; DOI: 10.1136/jitc-2021-003264
Bispecific antibodies targeting CD40 and tumor-associated antigens promote cross-priming of T cells resulting in an antitumor response superior to monospecific antibodies
Karin Hägerbrand, Laura Varas, Adnan Deronic, Barnabas Nyesiga, Anette Sundstedt, Lill Ljung, Christina Sakellariou, Doreen Werchau, Mia Thagesson, David Gomez Jimenez, Lennart Greiff, Mona Celander, Kristine Smedenfors, Anna Rosén, Deniz Bölükbas, Fredrika Carlsson, Mattias Levin, Anna Säll, Laura von Schantz, Malin Lindstedt, Peter Ellmark

Journal for ImmunoTherapy of Cancer Nov 2022, 10 (11) e005018; DOI: 10.1136/jitc-2022-005018
An anti-mesothelin targeting antibody drug conjugate induces pyroptosis and ignites antitumor immunity in mouse models of cancer
Nicole L Wittwer, Alexander H Staudacher, Vasilios Liapis, Pina Cardarelli, Harriet Warren, Michael P Brown

Journal for ImmunoTherapy of Cancer Mar 2023, 11 (3) e006274; DOI: 10.1136/jitc-2022-006274
Immunotherapy reverses glioma-driven dysfunction of immune system homeostasis
Bayli DiVita Dean, Tyler Wildes, Joseph Dean, Oleg Yegorov, Changlin Yang, David Shin, Connor Francis, John W Figg, Mathew Sebastian, Laura Falceto Font, Dan Jin, Alexandra Reid, Ginger Moore, Brandon Fernandez, Brandon Wummer, Carmelle Kuizon, Duane Mitchell, Catherine T Flores

Journal for ImmunoTherapy of Cancer Feb 2023, 11 (2) e004805; DOI: 10.1136/jitc-2022-004805
Senescent cancer cell vaccines induce cytotoxic T cell responses targeting primary tumors and disseminated tumor cells
Yue Liu, Joanna Pagacz, Donald J Wolfgeher, Kenneth D Bromerg, Jacob V Gorman, Stephen J Kron

Journal for ImmunoTherapy of Cancer Feb 2023, 11 (2) e005862; DOI: 10.1136/jitc-2022-005862
Immune landscape in vulvar cancer-draining lymph nodes indicates distinct immune escape mechanisms in support of metastatic spread and growth
Anne Marijne Heeren, Jossie Rotman, Sanne Samuels, Henry J M A A Zijlmans, Guus Fons, Koen K van de Vijver, Maaike C G Bleeker, Gemma G Kenter, Ekaterina J Jordanova, Tanja D de Gruijl

Journal for ImmunoTherapy of Cancer Oct 2021, 9 (10) e003623; DOI: 10.1136/jitc-2021-003623
Dendritic cell vaccines targeting tumor blood vessel antigens in combination with dasatinib induce therapeutic immune responses in patients with checkpoint-refractory advanced melanoma
Walter J Storkus, Deena Maurer, Yan Lin, Fei Ding, Anamika Bose, Devin Lowe, Amy Rose, Melissa DeMark, Lilit Karapetyan, Jennifer L Taylor, Manoj Chelvanambi, Ronald J Fecek, Jessica N Filderman, Timothy J Looney, Lauren Miller, Elizabeth Linch, Geoffrey M Lowman, Pawel Kalinski, Lisa H Butterfield, Ahmad Tarhini, Hussein Tawbi, John M Kirkwood

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e003675; DOI: 10.1136/jitc-2021-003675
Intratumoral co-injection of the poly I:C-derivative BO-112 and a STING agonist synergize to achieve local and distant anti-tumor efficacy
Maite Alvarez, Carmen Molina, Carlos E De Andrea, Myriam Fernandez-Sendin, Maria Villalba, Jose Gonzalez-Gomariz, Maria Carmen Ochoa, Alvaro Teijeira, Javier Glez-Vaz, Fernando Aranda, Miguel F Sanmamed, Maria E Rodriguez-Ruiz, Xinyi Fan, Wen H Shen, Pedro Berraondo, Marisol Quintero, Ignacio Melero

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e002953; DOI: 10.1136/jitc-2021-002953

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