drug evaluation

DPP inhibition alters the CXCR3 axis and enhances NK and CD8+ T cell infiltration to improve anti-PD1 efficacy in murine models of pancreatic ductal adenocarcinoma
Allison A Fitzgerald, Shangzi Wang, Veena Agarwal, Emily F Marcisak, Annie Zuo, Sandra A Jablonski, Melanie Loth, Elana J Fertig, John MacDougall, Eugene Zhukovsky, Shubhendu Trivedi, Dimple Bhatia, Vince O'Neill, Louis M Weiner

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e002837; DOI: 10.1136/jitc-2021-002837
BT7480, a novel fully synthetic Bicycle tumor-targeted immune cell agonist™ (Bicycle TICA™) induces tumor localized CD137 agonism
Kristen Hurov, Johanna Lahdenranta, Punit Upadhyaya, Eric Haines, Heather Cohen, Elizabeth Repash, Drasti Kanakia, Jun Ma, Julia Kristensson, Fanglei You, Carly Campbell, David Witty, Mike Kelly, Stephen Blakemore, Phil Jeffrey, Kevin McDonnell, Philip Brandish, Nicholas Keen

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e002883; DOI: 10.1136/jitc-2021-002883
Synergistic antitumor activity of pan-PI3K inhibition and immune checkpoint blockade in bladder cancer
Shaoming Zhu, A-Hong Ma, Zheng Zhu, Elio Adib, Ting Rao, Na Li, Kaiyuan Ni, Veera Chandra Sekhar Reddy Chittepu, Rao Prabhala, Juan Garisto Risco, David Kwiatkowski, Kent Mouw, Guru Sonpavde, Fan Cheng, Chong-xian Pan

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e002917; DOI: 10.1136/jitc-2021-002917
Novel phosphatidylserine-binding molecule enhances antitumor T-cell responses by targeting immunosuppressive exosomes in human tumor microenvironments
Maulasri Bhatta, Gautam N Shenoy, Jenni L Loyall, Brian D Gray, Meghana Bapardekar, Alexis Conway, Hans Minderman, Raymond J Kelleher Jr, Beatriz M Carreno, Gerald Linette, Leonard D Shultz, Kunle Odunsi, Sathy V Balu-Iyer, Koon Yan Pak, Richard B Bankert

Journal for ImmunoTherapy of Cancer Oct 2021, 9 (10) e003148; DOI: 10.1136/jitc-2021-003148
GB1275, a first-in-class CD11b modulator: rationale for immunotherapeutic combinations in solid tumors
David G DeNardo, Anna Galkin, Jakob Dupont, Lei Zhou, Johanna Bendell

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e003005; DOI: 10.1136/jitc-2021-003005
Do the benefits of being a smoker hint at the existence of PD-1/PD-L1 sensitizers for patients on single-agent immunotherapy?
Gintaras Zaleskis, Vita Pasukoniene, Dainius Characiejus, Vincas Urbonas

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e003191; DOI: 10.1136/jitc-2021-003191
Src/lck inhibitor dasatinib reversibly switches off cytokine release and T cell cytotoxicity following stimulation with T cell bispecific antibodies
Gabrielle Leclercq, Hélène Haegel, Anneliese Schneider, Anna Maria Giusti, Estelle Marrer-Berger, Christophe Boetsch, Antje-Christine Walz, Vesna Pulko, Johannes Sam, John Challier, Cristiano Ferlini, Alex Odermatt, Pablo Umaña, Marina Bacac, Christian Klein

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002582; DOI: 10.1136/jitc-2021-002582
p38 MAPK signaling in M1 macrophages results in selective elimination of M2 macrophages by MEK inhibition
Daniel Baumann, Jennifer Drebant, Tanja Hägele, Luisa Burger, Clara Serger, Claudia Lauenstein, Przemyslaw Dudys, Gerrit Erdmann, Rienk Offringa

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002319; DOI: 10.1136/jitc-2020-002319
Oral SMEDDS promotes lymphatic transport and mesenteric lymph nodes target of chlorogenic acid for effective T-cell antitumor immunity
Jun Ye, Yue Gao, Ming Ji, Yanfang Yang, Zhaohui Wang, Baolian Wang, Jing Jin, Ling Li, Hongliang Wang, Xiaoyan Xu, Hengfeng Liao, Chunfang Lian, Yaqi Xu, Renjie Li, Tong Sun, Lili Gao, Yan Li, Xiaoguang Chen, Yuling Liu

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002753; DOI: 10.1136/jitc-2021-002753
Metformin generates profound alterations in systemic and tumor immunity with associated antitumor effects
Ratna Veeramachaneni, Wangjie Yu, Jared M Newton, Jan O Kemnade, Heath D Skinner, Andrew G Sikora, Vlad C Sandulache

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002773; DOI: 10.1136/jitc-2021-002773

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