gastrointestinal neoplasms

Tissue-resident memory T cells in gastrointestinal cancer immunology and immunotherapy: ready for prime time?
Syrine Abdeljaoued, Sara Arfa, Marie Kroemer, Myriam Ben Khelil, Angélique Vienot, Bruno Heyd, Romain Loyon, Alexandre Doussot, Christophe Borg

Journal for ImmunoTherapy of Cancer Apr 2022, 10 (4) e003472; DOI: 10.1136/jitc-2021-003472
Assessment of hyperprogression versus the natural course of disease development with nivolumab with or without ipilimumab versus placebo in phase III, randomized, controlled trials
Yoon-Koo Kang, Martin Reck, Paul Nghiem, Yan Feng, Gregory Plautz, Hye Ryun Kim, Taofeek K Owonikoko, Narikazu Boku, Li-Tzong Chen, Ming Lei, Han Chang, Wen Hong Lin, Amit Roy, Akintunde Bello, Jennifer Sheng

Journal for ImmunoTherapy of Cancer Apr 2022, 10 (4) e004273; DOI: 10.1136/jitc-2021-004273
Effect of neoadjuvant chemotherapy on the immune microenvironment in gastric cancer as determined by multiplex immunofluorescence and T cell receptor repertoire analysis
Xiaofang Xing, Jinyao Shi, Yongning Jia, Yunsheng Dou, Zhongwu Li, Bin Dong, Ting Guo, Xiaojing Cheng, Xiaomei Li, Hong Du, Ying Hu, Shuqin Jia, Jian Zhang, Ziyu Li, Jiafu Ji

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e003984; DOI: 10.1136/jitc-2021-003984
Phase I, multicenter, open-label study of intravenous VCN-01 oncolytic adenovirus with or without nab-paclitaxel plus gemcitabine in patients with advanced solid tumors
Rocio Garcia-Carbonero, Miriam Bazan-Peregrino, Marta Gil-Martín, Rafael Álvarez, Teresa Macarulla, Maria C Riesco-Martinez, Helena Verdaguer, Carmen Guillén-Ponce, Martí Farrera-Sal, Rafael Moreno, Ana Mato-Berciano, Maria Victoria Maliandi, Silvia Torres-Manjon, Marcel Costa, Natalia del Pozo, Jaime Martínez de Villarreal, Francisco X Real, Noemí Vidal, Gabriel Capella, Ramon Alemany, Emma Blasi, Carmen Blasco, Manel Cascalló, Ramon Salazar

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e003255; DOI: 10.1136/jitc-2021-003255
Efficacy and safety of neoadjuvant sintilimab, oxaliplatin and capecitabine in patients with locally advanced, resectable gastric or gastroesophageal junction adenocarcinoma: early results of a phase 2 study
Haiping Jiang, Xiongfei Yu, Ning Li, Mei Kong, Zhimin Ma, Donghui Zhou, Weibin Wang, Haohao Wang, Haiyong Wang, Kuifeng He, Zhongqi Li, Yimin Lu, Jing Zhang, Kui Zhao, Yafei Zhang, Nong Xu, Ziran Li, Ying Liu, Yan Wang, Yisen Wang, Lisong Teng

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e003635; DOI: 10.1136/jitc-2021-003635
Oncolytic peptide LTX-315 induces anti-pancreatic cancer immunity by targeting the ATP11B-PD-L1 axis
Tianyu Tang, Xing Huang, Gang Zhang, Minghao Lu, Zhengtao Hong, Meng Wang, Junming Huang, Xiao Zhi, Tingbo Liang

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e004129; DOI: 10.1136/jitc-2021-004129
Differential role of HLA-A and HLA-B, C expression levels as prognostic markers in colon and rectal cancer
Theodoros Michelakos, Filippos Kontos, Tomohiro Kurokawa, Lei Cai, Ananthan Sadagopan, Danielle Krijgsman, Wilko Weichert, Lindy G Durrant, Peter J K Kuppen, Cristina R Ferrone, Soldano Ferrone

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e004115; DOI: 10.1136/jitc-2021-004115
Enhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease cathepsin S
Tom J Harryvan, Marten Visser, Linda de Bruin, Léonie Plug, Lisa Griffioen, Arend Mulder, Peter A van Veelen, Gerbrand J van der Heden van Noort, Marlieke LM Jongsma, Miranda H Meeuwsen, Emmanuel JHJ Wiertz, Saskia J Santegoets, James CH Hardwick, Thorbald Van Hall, Jacques Neefjes, Sjoerd H Van der Burg, Lukas JAC Hawinkels, Els ME Verdegaal

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e003591; DOI: 10.1136/jitc-2021-003591
Combination cancer immunotherapy targeting TNFR2 and PD-1/PD-L1 signaling reduces immunosuppressive effects in the microenvironment of pancreatic tumors
Xiaozhen Zhang, Mengyi Lao, Jian Xu, Yi Duan, Hanshen Yang, Muchun Li, Honggang Ying, Lihong He, Kang Sun, Chengxiang Guo, Wen Chen, Haitao Jiang, Xiaoyu Zhang, Xueli Bai, Tingbo Liang

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e003982; DOI: 10.1136/jitc-2021-003982
In PD-1+ human colon cancer cells NIVOLUMAB promotes survival and could protect tumor cells from conventional therapies
Caterina Ieranò, Dario Righelli, Crescenzo D'Alterio, Maria Napolitano, Luigi Portella, Giuseppina Rea, Federica Auletta, Sara Santagata, Anna Maria Trotta, Giuseppe Guardascione, Federica Liotti, Nella Prevete, Piera Maiolino, Antonio Luciano, Antonio Barbieri, Annabella Di Mauro, Cristin Roma, Riziero Esposito Abate, Fabiana Tatangelo, Roberto Pacelli, Nicola Normanno, Rosa Marina Melillo, Stefania Scala

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e004032; DOI: 10.1136/jitc-2021-004032

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