gastrointestinal neoplasms

DNA methylation-based signature of CD8+ tumor-infiltrating lymphocytes enables evaluation of immune response and prognosis in colorectal cancer
Qi Zou, Xiaolin Wang, Donglin Ren, Bang Hu, Guannan Tang, Yu Zhang, Meijin Huang, Rish K Pai, Daniel D Buchanan, Aung Ko Win, Polly A Newcomb, William M Grady, Huichuan Yu, Yanxin Luo

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002671; DOI: 10.1136/jitc-2021-002671
Intratumoral injection of TLR9 agonist promotes an immunopermissive microenvironment transition and causes cooperative antitumor activity in combination with anti-PD1 in pancreatic cancer
Carmine Carbone, Geny Piro, Antonio Agostini, Pietro Delfino, Francesco De Sanctis, Vincenzo Nasca, Francesco Spallotta, Claudio Sette, Maurizio Martini, Stefano Ugel, Vincenzo Corbo, Paola Cappello, Emilio Bria, Aldo Scarpa, Giampaolo Tortora

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002876; DOI: 10.1136/jitc-2021-002876
CXCR6 is required for antitumor efficacy of intratumoral CD8⁺ T cell
Binglin Wang, Yi Wang, Xiaofan Sun, Guoliang Deng, Wei Huang, Xingxin Wu, Yanghong Gu, Zhigang Tian, Zhimin Fan, Qiang Xu, Hongqi Chen, Yang Sun

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e003100; DOI: 10.1136/jitc-2021-003100
Nomogram to predict the outcomes of patients with microsatellite instability-high metastatic colorectal cancer receiving immune checkpoint inhibitors
Filippo Pietrantonio, Sara Lonardi, Francesca Corti, Gabriele Infante, Maria Elena Elez, Marwan Fakih, Priya Jayachandran, Aakash Tushar Shah, Massimiliano Salati, Elisabetta Fenocchio, Lisa Salvatore, Giuseppe Curigliano, Chiara Cremolini, Margherita Ambrosini, Javier Ros, Rossana Intini, Floriana Nappo, Silvia Damian, Federica Morano, Giovanni Fucà, Michael Overman, Rosalba Miceli

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e003370; DOI: 10.1136/jitc-2021-003370
Tumor microenvironment evaluation promotes precise checkpoint immunotherapy of advanced gastric cancer
Dongqiang Zeng, Jiani Wu, Huiyan Luo, Yong Li, Jian Xiao, Jianjun Peng, Zilan Ye, Rui Zhou, Yunfang Yu, Gaofeng Wang, Na Huang, Jianhua Wu, Xiaoxiang Rong, Li Sun, Huiying Sun, Wenjun Qiu, Yichen Xue, Jianping Bin, Yulin Liao, Nailin Li, Min Shi, Kyoung-Mee Kim, Wangjun Liao

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e002467; DOI: 10.1136/jitc-2021-002467
Direct identification of neoantigen-specific TCRs from tumor specimens by high-throughput single-cell sequencing
Yong-Chen Lu, Zhili Zheng, Frank J Lowery, Jared J Gartner, Todd D Prickett, Paul F Robbins, Steven A Rosenberg

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002595; DOI: 10.1136/jitc-2021-002595
PD-L1 targeting and subclonal immune escape mediated by PD-L1 mutations in metastatic colorectal cancer
Alexander Stein, Donjete Simnica, Christoph Schultheiß, Rebekka Scholz, Joseph Tintelnot, Eray Gökkurt, Lisa von Wenserski, Edith Willscher, Lisa Paschold, Markus Sauer, Sylvie Lorenzen, Jorge Riera-Knorrenschild, Reinhard Depenbusch, Thomas J Ettrich, Steffen Dörfel, Salah-Eddin Al-Batran, Meinolf Karthaus, Uwe Pelzer, Lisa Waberer, Axel Hinke, Marcus Bauer, Chiara Massa, Barbara Seliger, Claudia Wickenhauser, Carsten Bokemeyer, Susanna Hegewisch-Becker, Mascha Binder

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002844; DOI: 10.1136/jitc-2021-002844
CD11b⁺CTLA4⁺ myeloid cells are a key driver of tumor evasion in colorectal cancer
Hiroshi Imazeki, Yamato Ogiwara, Mami Kawamura, Narikazu Boku, Chie Kudo-Saito

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002841; DOI: 10.1136/jitc-2021-002841
Author response to Colle et al
Giovanni Fucà, Francesca Corti, Filippo Pietrantonio

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e003138; DOI: 10.1136/jitc-2021-003138
Letter to the Editor from Colle et al
Raphael Colle, Thierry Andre, Yves Menu

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002997; DOI: 10.1136/jitc-2021-002997

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