gastrointestinal neoplasms

IFN-γ treatment protocol for MHC-I^lo/PD-L1⁺ pancreatic tumor cells selectively restores their TAP-mediated presentation competence and CD8 T-cell priming potential
Katja Stifter, Jana Krieger, Leonie Ruths, Johann Gout, Medhanie Mulaw, Andre Lechel, Alexander Kleger, Thomas Seufferlein, Martin Wagner, Reinhold Schirmbeck

Journal for ImmunoTherapy of Cancer Aug 2020, 8 (2) e000692; DOI: 10.1136/jitc-2020-000692
Somatic POLE exonuclease domain mutations elicit enhanced intratumoral immune responses in stage II colorectal cancer
Shaobo Mo, Xiaoji Ma, Yaqi Li, Long Zhang, Ting Hou, Han Han-Zhang, Juanjuan Qian, Sanjun Cai, Dan Huang, Junjie Peng

Journal for ImmunoTherapy of Cancer Aug 2020, 8 (2) e000881; DOI: 10.1136/jitc-2020-000881
Chimeric Ad5.F35 vector evades anti-adenovirus serotype 5 neutralization opposing GUCY2C-targeted antitumor immunity
John C Flickinger Jr, Jagmohan Singh, Robert Carlson, Elinor Leong, Trevor R Baybutt, Joshua Barton, Ellen Caparosa, Amanda Pattison, Jeffrey A Rappaport, Jamin Roh, Tingting Zhan, Babar Bashir, Scott A Waldman, Adam E Snook

Journal for ImmunoTherapy of Cancer Aug 2020, 8 (2) e001046; DOI: 10.1136/jitc-2020-001046
Prediction of immune checkpoint inhibition with immune oncology-related gene expression in gastrointestinal cancer using a machine learning classifier
Zhihao Lu, Huan Chen, Xi Jiao, Wei Zhou, Wenbo Han, Shuang Li, Chang Liu, Jifang Gong, Jian Li, Xiaotian Zhang, Xicheng Wang, Zhi Peng, Changsong Qi, Zhenghang Wang, Yanyan Li, Jie Li, Yan Li, Malcolm Brock, Henghui Zhang, Lin Shen

Journal for ImmunoTherapy of Cancer Aug 2020, 8 (2) e000631; DOI: 10.1136/jitc-2020-000631
Durable benefit from immunotherapy and accompanied lupus erythematosus in pancreatic adenocarcinoma with DNA repair deficiency
Xionghao Pang, Juanjuan Qian, Hua Jin, Lei Zhang, Lin Lin, Yuli Wang, Yi Lei, Zeqiang Zhou, Meixiang Li, Henghui Zhang

Journal for ImmunoTherapy of Cancer Jul 2020, 8 (2) e000463; DOI: 10.1136/jitc-2019-000463
Phase I study of bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with pretreated biliary tract cancer
Changhoon Yoo, Do-Youn Oh, Hye Jin Choi, Masatoshi Kudo, Makoto Ueno, Shunsuke Kondo, Li-Tzong Chen, Motonobu Osada, Christoph Helwig, Isabelle Dussault, Masafumi Ikeda

Journal for ImmunoTherapy of Cancer May 2020, 8 (1) e000564; DOI: 10.1136/jitc-2020-000564
Overcoming resistance to anti-PD1 and anti-PD-L1 treatment in gastrointestinal malignancies
Alberto Puccini, Francesca Battaglin, Maria Laura Iaia, Heinz-Josef Lenz, Mohamed E Salem

Journal for ImmunoTherapy of Cancer May 2020, 8 (1) e000404; DOI: 10.1136/jitc-2019-000404
PRKDC: new biomarker and drug target for checkpoint blockade immunotherapy
Kien Thiam Tan, Chun-Nan Yeh, Yu-Chan Chang, Jen-Hao Cheng, Wen-Liang Fang, Yi-Chen Yeh, Yu-Chao Wang, Dennis Shin-Shian Hsu, Chiao-En Wu, Jiun-I Lai, Peter Mu-Hsin Chang, Ming-Han Chen, Meng-Lun Lu, Shu-Jen Chen, Yee Chao, Michael Hsiao, Ming-Huang Chen

Journal for ImmunoTherapy of Cancer Mar 2020, 8 (1) e000485; DOI: 10.1136/jitc-2019-000485

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gastrointestinal neoplasms