gastrointestinal neoplasms

Complement downregulation promotes an inflammatory signature that renders colorectal cancer susceptible to immunotherapy
Carsten Krieg, Lukas M Weber, Bruno Fosso, Marinella Marzano, Gary Hardiman, Monica M Olcina, Enric Domingo, Sahar El Aidy, Khalil Mallah, Mark D Robinson, Silvia Guglietta

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e004717; DOI: 10.1136/jitc-2022-004717
Neoadjuvant immunotherapy of locoregionally advanced solid tumors
Ahmad A Tarhini, Jennifer R Eads, Kathleen N Moore, Valerie Tatard-Leitman, John Wright, Patrick M Forde, Robert L Ferris

Journal for ImmunoTherapy of Cancer Aug 2022, 10 (8) e005036; DOI: 10.1136/jitc-2022-005036
CD40×HER2 bispecific antibody overcomes the CCL2-induced trastuzumab resistance in HER2-positive gastric cancer
Weilin Sun, Xi Wang, Daohan Wang, Li Lu, Hai Lin, Zhaoxiong Zhang, Yangpu Jia, Xinyang Nie, Tong Liu, Weihua Fu

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e005063; DOI: 10.1136/jitc-2022-005063
Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer
Jian Ye, Bradley N Mills, Shuyang S Qin, Jesse Garrett-Larsen, Joseph D Murphy, Taylor P Uccello, Booyeon J Han, Tara G Vrooman, Carl J Johnston, Edith M Lord, Brian A Belt, David C Linehan, Scott A Gerber

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004784; DOI: 10.1136/jitc-2022-004784
Pathological complete response to immune checkpoint inhibitor in patients with colorectal cancer liver metastases harboring POLE exonuclease domain mutation
Lei Wen, Zhigang Chen, Xiaomeng Ji, William Pat Fong, Qiong Shao, Chao Ren, Yanyu Cai, Binkui Li, Yunfei Yuan, Deshen Wang, Yuhong Li

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004487; DOI: 10.1136/jitc-2022-004487
Local and systemic immune profiles of human pancreatic ductal adenocarcinoma revealed by single-cell mass cytometry
Thomas P Brouwer, Natasja L de Vries, Tamim Abdelaal, Ricki T Krog, Zheng Li, Dina Ruano, Arantza Fariña, Boudewijn P F Lelieveldt, Hans Morreau, Bert A Bonsing, Alexander L Vahrmeijer, Frits Koning, Noel F C C de Miranda

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004638; DOI: 10.1136/jitc-2022-004638
Phase II study of ceralasertib (AZD6738) in combination with durvalumab in patients with advanced gastric cancer
Minsuk Kwon, Gahyun Kim, Ryul Kim, Kyu-Tae Kim, Seung Tae Kim, Simon Smith, Peter G S Mortimer, Jung Yong Hong, Arsene-Bienvenu Loembé, Itziar Irurzun-Arana, Loumpiana Koulai, Kyoung-Mee Kim, Won Ki Kang, Emma Dean, Woong-Yang Park, Jeeyun Lee

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e005041; DOI: 10.1136/jitc-2022-005041
Development of anti-somatostatin receptors CAR T cells for treatment of neuroendocrine tumors
Barbara Mandriani, Eleonora Pellè, Francesco Mannavola, Antonio Palazzo, Renè Massimiliano Marsano, Giuseppe Ingravallo, Gerardo Cazzato, Maria Cecilia Ramello, Camillo Porta, Jonathan Strosberg, Daniel Abate-Daga, Mauro Cives

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004854; DOI: 10.1136/jitc-2022-004854
Resistance to systemic immune checkpoint inhibition in the peritoneal niche
Daryl Kai Ann Chia, Yong Xiang Gwee, Raghav Sundar

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004749; DOI: 10.1136/jitc-2022-004749
Detection of microsatellite instability-high (MSI-H) by liquid biopsy predicts robust and durable response to immunotherapy in patients with pancreatic cancer
Sakti Chakrabarti, Leslie Bucheit, Jason Scott Starr, Racquel Innis-Shelton, Ardaman Shergill, Hiba Dada, Regina Resta, Stephanie Wagner, Naomi Fei, Pashtoon Murtaza Kasi

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004485; DOI: 10.1136/jitc-2021-004485

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