gastrointestinal neoplasms

DNA methylation-based signature of CD8+ tumor-infiltrating lymphocytes enables evaluation of immune response and prognosis in colorectal cancer
Qi Zou, Xiaolin Wang, Donglin Ren, Bang Hu, Guannan Tang, Yu Zhang, Meijin Huang, Rish K Pai, Daniel D Buchanan, Aung Ko Win, Polly A Newcomb, William M Grady, Huichuan Yu, Yanxin Luo

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002671; DOI: 10.1136/jitc-2021-002671
Phase II study of pembrolizumab in refractory esophageal cancer with correlates of response and survival
Leonie K de Klerk, Anuj K Patel, Sarah Derks, Eirini Pectasides, Jeremy Augustin, Mohamed Uduman, Nihal Raman, Fahire G Akarca, Nadine J McCleary, James M Cleary, Douglas A Rubinson, Jeffrey W Clark, Bridget Fitzpatrick, Lauren K Brais, Megan E Cavanaugh, Amanda J Rode, Melissa G Jean, Patrick H Lizotte, Matthew J Nazzaro, Mariano Severgnini, Hui Zheng, Charles S Fuchs, Peter C Enzinger, Adam J Bass

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002472; DOI: 10.1136/jitc-2021-002472
Inactivation of interleukin-30 in colon cancer stem cells via CRISPR/Cas9 genome editing inhibits their oncogenicity and improves host survival
Luigi D'Antonio, Cristiano Fieni, Stefania Livia Ciummo, Simone Vespa, Lavinia Lotti, Carlo Sorrentino, Emma Di Carlo

Journal for ImmunoTherapy of Cancer Mar 2023, 11 (3) e006056; DOI: 10.1136/jitc-2022-006056
CD40×HER2 bispecific antibody overcomes the CCL2-induced trastuzumab resistance in HER2-positive gastric cancer
Weilin Sun, Xi Wang, Daohan Wang, Li Lu, Hai Lin, Zhaoxiong Zhang, Yangpu Jia, Xinyang Nie, Tong Liu, Weihua Fu

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e005063; DOI: 10.1136/jitc-2022-005063
Combination cancer immunotherapy targeting TNFR2 and PD-1/PD-L1 signaling reduces immunosuppressive effects in the microenvironment of pancreatic tumors
Xiaozhen Zhang, Mengyi Lao, Jian Xu, Yi Duan, Hanshen Yang, Muchun Li, Honggang Ying, Lihong He, Kang Sun, Chengxiang Guo, Wen Chen, Haitao Jiang, Xiaoyu Zhang, Xueli Bai, Tingbo Liang

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e003982; DOI: 10.1136/jitc-2021-003982
Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer
Jian Ye, Bradley N Mills, Shuyang S Qin, Jesse Garrett-Larsen, Joseph D Murphy, Taylor P Uccello, Booyeon J Han, Tara G Vrooman, Carl J Johnston, Edith M Lord, Brian A Belt, David C Linehan, Scott A Gerber

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004784; DOI: 10.1136/jitc-2022-004784
Oncolytic peptide LTX-315 induces anti-pancreatic cancer immunity by targeting the ATP11B-PD-L1 axis
Tianyu Tang, Xing Huang, Gang Zhang, Minghao Lu, Zhengtao Hong, Meng Wang, Junming Huang, Xiao Zhi, Tingbo Liang

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e004129; DOI: 10.1136/jitc-2021-004129
Efficacy and safety of neoadjuvant sintilimab, oxaliplatin and capecitabine in patients with locally advanced, resectable gastric or gastroesophageal junction adenocarcinoma: early results of a phase 2 study
Haiping Jiang, Xiongfei Yu, Ning Li, Mei Kong, Zhimin Ma, Donghui Zhou, Weibin Wang, Haohao Wang, Haiyong Wang, Kuifeng He, Zhongqi Li, Yimin Lu, Jing Zhang, Kui Zhao, Yafei Zhang, Nong Xu, Ziran Li, Ying Liu, Yan Wang, Yisen Wang, Lisong Teng

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e003635; DOI: 10.1136/jitc-2021-003635
Phase I, multicenter, open-label study of intravenous VCN-01 oncolytic adenovirus with or without nab-paclitaxel plus gemcitabine in patients with advanced solid tumors
Rocio Garcia-Carbonero, Miriam Bazan-Peregrino, Marta Gil-Martín, Rafael Álvarez, Teresa Macarulla, Maria C Riesco-Martinez, Helena Verdaguer, Carmen Guillén-Ponce, Martí Farrera-Sal, Rafael Moreno, Ana Mato-Berciano, Maria Victoria Maliandi, Silvia Torres-Manjon, Marcel Costa, Natalia del Pozo, Jaime Martínez de Villarreal, Francisco X Real, Noemí Vidal, Gabriel Capella, Ramon Alemany, Emma Blasi, Carmen Blasco, Manel Cascalló, Ramon Salazar

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e003255; DOI: 10.1136/jitc-2021-003255
Effect of neoadjuvant chemotherapy on the immune microenvironment in gastric cancer as determined by multiplex immunofluorescence and T cell receptor repertoire analysis
Xiaofang Xing, Jinyao Shi, Yongning Jia, Yunsheng Dou, Zhongwu Li, Bin Dong, Ting Guo, Xiaojing Cheng, Xiaomei Li, Hong Du, Ying Hu, Shuqin Jia, Jian Zhang, Ziyu Li, Jiafu Ji

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e003984; DOI: 10.1136/jitc-2021-003984

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