gastrointestinal neoplasms

In PD-1+ human colon cancer cells NIVOLUMAB promotes survival and could protect tumor cells from conventional therapies
Caterina Ieranò, Dario Righelli, Crescenzo D'Alterio, Maria Napolitano, Luigi Portella, Giuseppina Rea, Federica Auletta, Sara Santagata, Anna Maria Trotta, Giuseppe Guardascione, Federica Liotti, Nella Prevete, Piera Maiolino, Antonio Luciano, Antonio Barbieri, Annabella Di Mauro, Cristin Roma, Riziero Esposito Abate, Fabiana Tatangelo, Roberto Pacelli, Nicola Normanno, Rosa Marina Melillo, Stefania Scala

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e004032; DOI: 10.1136/jitc-2021-004032
Identification of natural product 3, 5-diiodotyrosine as APOBEC3B inhibitor to prevent somatic mutation accumulation and cancer progression
Chunxia Chen, Xinghua Sui, Haoming Ning, Yixuan Sun, Jiangfeng Du, Xiaotong Chen, Xiuman Zhou, Guanyu Chen, Wenhui Shen, Liwei Pang, Xiaowen Zhou, Ranran Shi, Wanqiong Li, Hongfei Wang, Wenshan Zhao, Wenjie Zhai, Yuanming Qi, Yahong Wu, Yanfeng Gao

Journal for ImmunoTherapy of Cancer Nov 2022, 10 (11) e005503; DOI: 10.1136/jitc-2022-005503
T cells of colorectal cancer patients’ stimulated by neoantigenic and cryptic peptides better recognize autologous tumor cells
Sandra Schwarz, Johanna Schmitz, Markus W Löffler, Michael Ghosh, Hans-Georg Rammensee, Evgenia Olshvang, Marvin Markel, Nadine Mockel-Tenbrinck, Andrzej Dzionek, Susann Krake, Basak Arslan, Kapil Dev Kampe, Anne Wendt, Peter Bauer, Christina S Mullins, Andreas Schlosser, Michael Linnebacher

Journal for ImmunoTherapy of Cancer Dec 2022, 10 (12) e005651; DOI: 10.1136/jitc-2022-005651
Silence of a dependence receptor CSF1R in colorectal cancer cells activates tumor-associated macrophages
Mingxuan Zhu, Liangliang Bai, Xiaoxia Liu, Shaoyong Peng, Yumo Xie, Hong Bai, Huichuan Yu, Xiaolin Wang, Ping Yuan, Rui Ma, Jinxin Lin, Linping Wu, Meijin Huang, Yingjie Li, Yanxin Luo

Journal for ImmunoTherapy of Cancer Dec 2022, 10 (12) e005610; DOI: 10.1136/jitc-2022-005610
Targeting of colorectal cancer organoids with zoledronic acid conjugated to the anti-EGFR antibody cetuximab
Roberto Benelli, Delfina Costa, Laura Salvini, Samuele Tardito, Francesca Tosetti, Federico Villa, Maria Raffaella Zocchi, Alessandro Poggi

Journal for ImmunoTherapy of Cancer Dec 2022, 10 (12) e005660; DOI: 10.1136/jitc-2022-005660
MUC1-C is a master regulator of MICA/B NKG2D ligand and exosome secretion in human cancer cells
Yoshihiro Morimoto, Nami Yamashita, Tatsuaki Daimon, Haruka Hirose, Shizuka Yamano, Naoki Haratake, Satoshi Ishikawa, Atrayee Bhattacharya, Atsushi Fushimi, Rehan Ahmad, Hidekazu Takahashi, Olga Dashevsky, Constantine Mitsiades, Donald Kufe

Journal for ImmunoTherapy of Cancer Feb 2023, 11 (2) e006238; DOI: 10.1136/jitc-2022-006238
Neoadjuvant sintilimab and chemotherapy in patients with potentially resectable esophageal squamous cell carcinoma (KEEP-G 03): an open-label, single-arm, phase 2 trial
Xiaofeng Chen, Xiang Xu, Danping Wang, Jinyuan Liu, Jing Sun, Mingjie Lu, Rui Wang, Bingqing Hui, Xiaofei Li, Chenchen Zhou, Min Wang, Tianzhu Qiu, Shiyun Cui, Nana Sun, Yang Li, Fufeng Wang, Cuicui Liu, Yang Shao, Jinhua Luo, Yanhong Gu

Journal for ImmunoTherapy of Cancer Feb 2023, 11 (2) e005830; DOI: 10.1136/jitc-2022-005830
CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden
Jitske van den Bulk, Manon van der Ploeg, Marieke E Ijsselsteijn, Dina Ruano, Ruud van der Breggen, Rebekka Duhen, Koen C M J Peeters, Arantza Fariña-Sarasqueta, Els M E Verdegaal, Sjoerd H van der Burg, Thomas Duhen, Noel F C C de Miranda

Journal for ImmunoTherapy of Cancer Feb 2023, 11 (2) e005887; DOI: 10.1136/jitc-2022-005887
Empirical identification and validation of tumor-targeting T cell receptors from circulation using autologous pancreatic tumor organoids
Qingda Meng, Shanshan Xie, G Kenneth Gray, Mohammad H Dezfulian, Omar Gandarilla, Weilin Li, Ling Huang, Dipikaa Akshinthala, Elizabeth Ferrer, Catherine Conahan, Sofia Perea Del Pino, Joseph Grossman, Stephen J Elledge, Manuel Hidalgo, Senthil K Muthuswamy

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e003213; DOI: 10.1136/jitc-2021-003213
Low molecular weight heparin synergistically enhances the efficacy of adoptive and anti-PD-1-based immunotherapy by increasing lymphocyte infiltration in colorectal cancer
Yibo Quan, Jie He, Qi Zou, Liuxi Zhang, Qihui Sun, Hongli Huang, Wanglin Li, Keping Xie, Fang Wei

Journal for ImmunoTherapy of Cancer Aug 2023, 11 (8) e007080; DOI: 10.1136/jitc-2023-007080

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