immune evation

PD-L2 glycosylation promotes immune evasion and predicts anti-EGFR efficacy
Yiqi Xu, Zhenyue Gao, Ruxin Hu, Yuqing Wang, Yuhong Wang, Zheng Su, Xiaoyue Zhang, Jingxuan Yang, Mei Mei, Yu Ren, Min Li, Xuan Zhou

Journal for ImmunoTherapy of Cancer Oct 2021, 9 (10) e002699; DOI: 10.1136/jitc-2021-002699
Emerging role of tumor-derived extracellular vesicles in T cell suppression and dysfunction in the tumor microenvironment
Feiya Ma, Jensen Vayalil, Grace Lee, Yuqi Wang, Guangyong Peng

Journal for ImmunoTherapy of Cancer Oct 2021, 9 (10) e003217; DOI: 10.1136/jitc-2021-003217
Cystathionine β-synthase mediated PRRX2/IL-6/STAT3 inactivation suppresses Tregs infiltration and induces apoptosis to inhibit HCC carcinogenesis
Yu-Fu Zhou, Shu-Shu Song, Meng-Xin Tian, Zheng Tang, Han Wang, Yuan Fang, Wei-Feng Qu, Xi-Fei Jiang, Chen-Yang Tao, Run Huang, Pei-Yun Zhou, Shi-Guo Zhu, Jian Zhou, Jia Fan, Wei-Ren Liu, Ying-Hong Shi

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e003031; DOI: 10.1136/jitc-2021-003031
THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy
Chushu Li, Hao Chi, Shouyan Deng, Ke Xu, Huanbin Wang, Han Yao, Yungang Wang, Dawei Chen, Xun Guo, Jing-Yuan Fang, Fang He, Jie Xu

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e002443; DOI: 10.1136/jitc-2021-002443
WDR5-H3K4me3 epigenetic axis regulates OPN expression to compensate PD-L1 function to promote pancreatic cancer immune escape
Chunwan Lu, Zhuoqi Liu, John D Klement, Dafeng Yang, Alyssa D Merting, Dakota Poschel, Thomas Albers, Jennifer L Waller, Huidong Shi, Kebin Liu

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002624; DOI: 10.1136/jitc-2021-002624
ATM/NEMO signaling modulates the expression of PD-L1 following docetaxel chemotherapy in prostate cancer
Zongren Wang, Xueling Zhang, Wuguo Li, Qiao Su, Zhaoyang Huang, Xinyao Zhang, Haiqi Chen, Chengqiang Mo, Bin Huang, Wei Ou, Junxing Chen, Guangyin Zhao, Lingwu Chen, Lan Shao

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e001758; DOI: 10.1136/jitc-2020-001758
STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer
Seung Joon Lee, Hannah Yang, Woo Ram Kim, Yu Seong Lee, Won Suk Lee, So Jung Kong, Hye Jin Lee, Jeong Hun Kim, Jaekyung Cheon, Beodeul Kang, Hong Jae Chon, Chan Kim

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002195; DOI: 10.1136/jitc-2020-002195
Immune cell composition and functional marker dynamics from multiplexed immunohistochemistry to predict response to neoadjuvant chemotherapy in the WSG-ADAPT-TN trial
Monika Graeser, Friedrich Feuerhake, Oleg Gluz, Valery Volk, Michael Hauptmann, Katarzyna Jozwiak, Matthias Christgen, Sherko Kuemmel, Eva-Maria Grischke, Helmut Forstbauer, Michael Braun, Mathias Warm, John Hackmann, Christoph Uleer, Bahriye Aktas, Claudia Schumacher, Cornelia Kolberg-Liedtke, Ronald Kates, Rachel Wuerstlein, Ulrike Nitz, Hans Heinrich Kreipe, Nadia Harbeck

Journal for ImmunoTherapy of Cancer May 2021, 9 (5) e002198; DOI: 10.1136/jitc-2020-002198
IL-6 signaling in macrophages is required for immunotherapy-driven regression of tumors
Elham Beyranvand Nejad, Camilla Labrie, Marit J van Elsas, Jan Willem Kleinovink, Hans-Willi Mittrücker, Kees L M C Franken, Sylvia Heink, Thomas Korn, Ramon Arens, Thorbald van Hall, Sjoerd H van der Burg

Journal for ImmunoTherapy of Cancer Apr 2021, 9 (4) e002460; DOI: 10.1136/jitc-2021-002460
Orphan nuclear receptor TLX promotes immunosuppression via its transcriptional activation of PD-L1 in glioma
Jiayi Zhou, Xiaojuan Pei, Yingui Yang, Zhu Wang, Weijie Gao, Ran Ye, Xiantong Zhang, Jiangang Liu, Zhuohao Liu, Xinzhi Yang, Jingli Tao, Chunshan Gu, Wei Hu, Franky Lueng Chan, Xin Li, Jie Mao, Dinglan Wu

Journal for ImmunoTherapy of Cancer Apr 2021, 9 (4) e001937; DOI: 10.1136/jitc-2020-001937

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