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Immune inhibitory pathways
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Immune inhibitory pathways
Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8
+
T cells directly within the tumor microenvironment
Stefani
Spranger
,
Holly K
Koblish
,
Brendan
Horton
,
Peggy A
Scherle
,
Robert
Newton
,
Thomas F
Gajewski
Journal for ImmunoTherapy of Cancer
Dec 2014,
2
(1)
3;
DOI:
10.1186/2051-1426-2-3
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