Immunology

Fibroblast activation protein-targeted-4-1BB ligand agonist amplifies effector functions of intratumoral T cells in human cancer
Marta Trüb, Franziska Uhlenbrock, Christina Claus, Petra Herzig, Martin Thelen, Vaios Karanikas, Marina Bacac, Maria Amann, Rosemarie Albrecht, Claudia Ferrara-Koller, Daniela Thommen, Sacha Rothschield, Spasenija Savic Prince, Kirsten D Mertz, Gieri Cathomas, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Christian Klein, Heinz Laubli, Abhishek S Kashyap, Alfred Zippelius

Journal for ImmunoTherapy of Cancer Jul 2020, 8 (2) e000238; DOI: 10.1136/jitc-2019-000238
SOD3 induces a HIF-2α-dependent program in endothelial cells that provides a selective signal for tumor infiltration by T cells
Lorena Carmona-Rodríguez, Diego Martínez-Rey, Maria Jesús Fernández-Aceñero, Alicia González-Martín, Mateo Paz-Cabezas, Noe Rodríguez-Rodríguez, Beatriz Pérez-Villamil, Maria Eugenia Sáez, Eduardo Díaz-Rubio, Emilia Mira, Santos Mañes

Journal for ImmunoTherapy of Cancer Jun 2020, 8 (1) e000432; DOI: 10.1136/jitc-2019-000432
IL-6 promotes PD-L1 expression in monocytes and macrophages by decreasing protein tyrosine phosphatase receptor type O expression in human hepatocellular carcinoma
Wenjie Zhang, Yang Liu, Zhongyi Yan, Hui Yang, Wei Sun, Yongliang Yao, Yun Chen, Runqiu Jiang

Journal for ImmunoTherapy of Cancer Jun 2020, 8 (1) e000285; DOI: 10.1136/jitc-2019-000285
Involvement of the M-CSF/IL-34/CSF-1R pathway in malignant pleural mesothelioma
Thibaut Blondy, Sènan Mickael d'Almeida, Tina Briolay, Julie Tabiasco, Clément Meiller, Anne-Laure Chéné, Laurent Cellerin, Sophie Deshayes, Yves Delneste, Jean-François Fonteneau, Nicolas Boisgerault, Jaafar Bennouna, Marc Grégoire, Didier Jean, Christophe Blanquart

Journal for ImmunoTherapy of Cancer Jun 2020, 8 (1) e000182; DOI: 10.1136/jitc-2019-000182
CD3xCD19 DART molecule treatment induces non-apoptotic killing and is efficient against high-risk chemotherapy and venetoclax-resistant chronic lymphocytic leukemia cells
Anne W J Martens, Susanne R Janssen, Ingrid A M Derks, Homer C Adams III, Liat Izhak, Roel van Kampen, Sanne H Tonino, Eric Eldering, Gerritje J W van der Windt, Arnon P Kater

Journal for ImmunoTherapy of Cancer Jun 2020, 8 (1) e000218; DOI: 10.1136/jitc-2019-000218
Combination treatment with radiotherapy and a novel oxidative phosphorylation inhibitor overcomes PD-1 resistance and enhances antitumor immunity
Dawei Chen, Hampartsoum B Barsoumian, Grant Fischer, Liangpeng Yang, Vivek Verma, Ahmed I Younes, Yun Hu, Fatemeh Masropour, Katherine Klein, Christopher Vellano, Joseph Marszalek, Michael Davies, Maria Angelica Cortez, James Welsh

Journal for ImmunoTherapy of Cancer Jun 2020, 8 (1) e000289; DOI: 10.1136/jitc-2019-000289
MRI of tumor T cell infiltration in response to checkpoint inhibitor therapy
Xiaoyu Jiang, Stephanie Dudzinski, Kathryn E Beckermann, Kirsten Young, Eliot McKinley, Oliver J McIntyre, Jeffrey C Rathmell, Junzhong Xu, John C Gore

Journal for ImmunoTherapy of Cancer Jun 2020, 8 (1) e000328; DOI: 10.1136/jitc-2019-000328
CD200 promotes immunosuppression in the pancreatic tumor microenvironment
Fouad Choueiry, Molly Torok, Reena Shakya, Kriti Agrawal, Anna Deems, Brooke Benner, Alice Hinton, Jami Shaffer, Bradley W Blaser, Anne M Noonan, Terence M Williams, Mary Dillhoff, Darwin L Conwell, Phil A Hart, Zobeida Cruz-Monserrate, Xue-Feng Bai, William E Carson III, Thomas A Mace

Journal for ImmunoTherapy of Cancer Jun 2020, 8 (1) e000189; DOI: 10.1136/jitc-2019-000189
DNA damage repair pathway alterations in metastatic clear cell renal cell carcinoma and implications on systemic therapy
Yasser Ged, Joshua L Chaim, Renzo G DiNatale, Andrea Knezevic, Ritesh R Kotecha, Maria I Carlo, Chung-Han Lee, Ashley Foster, Darren R Feldman, Min Yuen Teo, Gopakumar Iyer, Timothy Chan, Sujata Patil, Robert J Motzer, A Ari Hakimi, Martin H Voss

Journal for ImmunoTherapy of Cancer Jun 2020, 8 (1) e000230; DOI: 10.1136/jitc-2019-000230
Role of the anatomic site in the association of HLA class I antigen expression level in metastases with clinical response to ipilimumab therapy in patients with melanoma
Andrea Ladányi, Eszter Papp, Anita Mohos, Tímea Balatoni, Gabriella Liszkay, Judit Oláh, Anita Varga, Zsuzsanna Lengyel, Gabriella Emri, Soldano Ferrone

Journal for ImmunoTherapy of Cancer Jun 2020, 8 (1) e000209; DOI: 10.1136/jitc-2019-000209

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