Immunotherapy

Additive effects of variants of unknown significance in replication repair-associated DNA polymerase genes on mutational burden and prognosis across diverse cancers
Jieer Ying, Lin Yang, Jiani C Yin, Guojie Xia, Minyan Xing, Xiaoxi Chen, Jiaohui Pang, Yong Wu, Hua Bao, Xue Wu, Yang Shao, Lingjun Zhu, Xiangdong Cheng

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002336; DOI: 10.1136/jitc-2021-002336
Effect of a multidisciplinary Severe Immunotherapy Complications Service on outcomes for patients receiving immune checkpoint inhibitor therapy for cancer
Leyre Zubiri, Gabriel E Molina, Meghan J Mooradian, Justine Cohen, Sienna M Durbin, Laura Petrillo, Genevieve M Boland, Dejan Juric, Michael Dougan, Molly F Thomas, Alex T Faje, Michelle Rengarajan, Amanda C Guidon, Steven T Chen, Daniel Okin, Benjamin D Medoff, Mazen Nasrallah, Minna J Kohler, Sara R Schoenfeld, Rebecca K Leaf, Meghan E Sise, Tomas G Neilan, Daniel A Zlotoff, Jocelyn R Farmer, Aditya Bardia, Ryan J Sullivan, Steven M Blum, Yevgeniy R Semenov, Alexandra-Chloé Villani, Kerry L Reynolds

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002886; DOI: 10.1136/jitc-2021-002886
Development of preclinical and clinical models for immune-related adverse events following checkpoint immunotherapy: a perspective from SITC and AACR
Nicholas L Bayless, Jeffrey A Bluestone, Samantha Bucktrout, Lisa H Butterfield, Elizabeth M Jaffee, Christian A Koch, Bart O Roep, Arlene H Sharpe, William J Murphy, Alexandra-Chloé Villani, Theresa L Walunas

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002627; DOI: 10.1136/jitc-2021-002627
Multiparametric MRI of early tumor response to immune checkpoint blockade in metastatic melanoma
Doreen Lau, Mary A McLean, Andrew N Priest, Andrew B Gill, Francis Scott, Ilse Patterson, Bruno Carmo, Frank Riemer, Joshua D Kaggie, Amy Frary, Doreen Milne, Catherine Booth, Arthur Lewis, Michal Sulikowski, Lee Brown, Jean-Martin Lapointe, Luigi Aloj, Martin J Graves, Kevin M Brindle, Pippa G Corrie, Ferdia A Gallagher

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e003125; DOI: 10.1136/jitc-2021-003125
Phase 1 open-label trial of intravenous administration of MVA-BN-brachyury-TRICOM vaccine in patients with advanced cancer
Peter J DeMaria, Katherine Lee-Wisdom, Renee N Donahue, Ravi A Madan, Fatima Karzai, Angie Schwab, Claudia Palena, Caroline Jochems, Charalampos Floudas, Julius Strauss, Jennifer L Marté, Jason Mark Redman, Eva Dombi, Brigitte Widemann, Borys Korchin, Tatiana Adams, Cesar Pico-Navarro, Christopher Heery, Jeffrey Schlom, James L Gulley, Marijo Bilusic

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e003238; DOI: 10.1136/jitc-2021-003238
Eosinophilic features in clear cell renal cell carcinoma correlate with outcomes of immune checkpoint and angiogenesis blockade
Takashi Yoshida, Chisato Ohe, Junichi Ikeda, Naho Atsumi, Haruyuki Ohsugi, Motohiko Sugi, Koichiro Higasa, Ryoichi Saito, Koji Tsuta, Tadashi Matsuda, Hidefumi Kinoshita

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002922; DOI: 10.1136/jitc-2021-002922
GDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma
Zhaowei Wang, Lei He, Weina Li, Chuanyang Xu, Jieyu Zhang, Desheng Wang, Kefeng Dou, Ran Zhuang, Boquan Jin, Wei Zhang, Qiang Hao, Kuo Zhang, Wangqian Zhang, Shuning Wang, Yuan Gao, Jintao Gu, Lei Shang, Zhijun Tan, Haichuan Su, Yingqi Zhang, Cun Zhang, Meng Li

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002787; DOI: 10.1136/jitc-2021-002787
Trends in clinical development of pediatric cancer for PD-1 and PD-L1 inhibitors: an analysis of ClinicalTrials.gov
Yi Que, Yang Hu, Dongchun Hong, Yizhuo Zhang

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002920; DOI: 10.1136/jitc-2021-002920
Novel potent anti-STEAP1 bispecific antibody to redirect T cells for cancer immunotherapy
Tsung-Yi Lin, Jeong A Park, Alan Long, Hong-Fen Guo, Nai-Kong V Cheung

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e003114; DOI: 10.1136/jitc-2021-003114
Elucidating mechanisms of antitumor immunity mediated by live oncolytic vaccinia and heat-inactivated vaccinia
Weiyi Wang, Shuaitong Liu, Peihong Dai, Ning Yang, Yi Wang, Rachel A Giese, Taha Merghoub, Jedd Wolchok, Liang Deng

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002569; DOI: 10.1136/jitc-2021-002569

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