Induce Tumor Regression

Innate and adaptive immunity contribute to the anti-tumor mechanisms of action of OncoVEX^mGM-CSF
Keegan Cooke, Karen Fitzgerald, Becky Yang, Petia Mitchell, Juan Estrada, Beltran Pedro, Achim K Moesta

Journal for ImmunoTherapy of Cancer Dec 2015, 3 (Suppl 2) P338; DOI: 10.1186/2051-1426-3-S2-P338
Agonist anti-4-1BB plus neutralizing anti-CTLA-4 or -PD-L1 synergize to promote tumor regression by rescuing dying dysfunctional CD8+ T cells within the tumor microenvironment
Brendan Horton, Jason B Williams, Stefani Spranger, Thomas F Gajewski

Journal for ImmunoTherapy of Cancer Dec 2015, 3 (Suppl 2) O10; DOI: 10.1186/2051-1426-3-S2-O10
Dual targeting of the tumor and its associated vasculature using a single bispecific chimeric antigen receptor molecule
Tiara Byrd, Kristen Fousek, Antonella Pignata, Amanda Wakefield, Zakaria Grada, Kevin Aviles-Padilla, Bradley S Fletcher, Meenakshi Hegde, Brad St Croix, Nabil Ahmed

Journal for ImmunoTherapy of Cancer Dec 2014, 2 (Suppl 3) P6; DOI: 10.1186/2051-1426-2-S3-P6
Tumor-specific donor lymphocyte infusion therapy with allogeneic T cells utilizing novel retrovirus vector silencing endogenous TCR expression
Hiroaki Ikeda, Hiroaki Ueno, Ayumi Kawamura, Naoko Imai, Sachiko Okamoto, Junichi Mineno, Kazutoh Takesako, Hiroshi Shiku

Journal for ImmunoTherapy of Cancer Dec 2014, 2 (Suppl 3) P20; DOI: 10.1186/2051-1426-2-S3-P20
Agonistic 4-1bb antibodies in combination with inhibitory antibodies against CTLA-4, PD-L1 or LAG-3 ACT on CD8+ T cells in the tumor microenvironment and synergize to promote regression of established tumors
Brendan Horton, Stefani Spranger, Jason Williams, Thomas Gajewski

Journal for ImmunoTherapy of Cancer Dec 2014, 2 (Suppl 3) P213; DOI: 10.1186/2051-1426-2-S3-P213

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Induce Tumor Regression