interferon inducers

Inhibiting DNA methylation and RNA editing upregulates immunogenic RNA to transform the tumor microenvironment and prolong survival in ovarian cancer
Stephanie Gomez, Olivia L Cox, Reddick R Walker, Uzma Rentia, Melissa Hadley, Elisa Arthofer, Noor Diab, Erin E Grundy, Tomas Kanholm, James I McDonald, Julie Kobyra, Erica Palmer, Satish Noonepalle, Alejandro Villagra, David Leitenberg, Catherine M Bollard, Yogen Saunthararajah, Katherine B Chiappinelli

Journal for ImmunoTherapy of Cancer Nov 2022, 10 (11) e004974; DOI: 10.1136/jitc-2022-004974
Combinations of Toll-like receptor 8 agonist TL8-506 activate human tumor-derived dendritic cells
Mi He, Bhavesh Soni, Petra C Schwalie, Tamara Hüsser, Caroline Waltzinger, Duvini De Silva, Ylva Prinz, Laura Krümpelmann, Samuele Calabro, Ines Matos, Christine Trumpfheller, Marina Bacac, Pablo Umaña, Mitchell P Levesque, Reinhard Dummer, Maries van den Broek, Stephan Gasser

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004268; DOI: 10.1136/jitc-2021-004268
TGFβ receptor inhibition unleashes interferon-β production by tumor-associated macrophages and enhances radiotherapy efficacy
Pauline Hamon, Marine Gerbé De Thoré, Marion Classe, Nicolas Signolle, Winchygn Liu, Olivia Bawa, Lydia Meziani, Céline Clémenson, Fabien Milliat, Eric Deutsch, Michele Mondini

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e003519; DOI: 10.1136/jitc-2021-003519
Immunostimulatory effects of radioimmunotherapy
Julie Constanzo, Lorenzo Galluzzi, Jean-Pierre Pouget

Journal for ImmunoTherapy of Cancer Feb 2022, 10 (2) e004403; DOI: 10.1136/jitc-2021-004403
Elucidating mechanisms of antitumor immunity mediated by live oncolytic vaccinia and heat-inactivated vaccinia
Weiyi Wang, Shuaitong Liu, Peihong Dai, Ning Yang, Yi Wang, Rachel A Giese, Taha Merghoub, Jedd Wolchok, Liang Deng

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002569; DOI: 10.1136/jitc-2021-002569
Statins act as transient type I interferon inhibitors to enable the antitumor activity of modified vaccinia Ankara viral vectors
Shirley Tenesaca, Marcos Vasquez, Maite Alvarez, Itziar Otano, Myriam Fernandez-Sendin, Claudia Augusta Di Trani, Nuria Ardaiz, Celia Gomar, Angela Bella, Fernando Aranda, José Medina-Echeverz, Ignacio Melero, Pedro Berraondo

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e001587; DOI: 10.1136/jitc-2020-001587
Oncolytic parainfluenza virus combines with NK cells to mediate killing of infected and non-infected lung cancer cells within 3D spheroids: role of type I and type III interferon signaling
Namita Varudkar, Jeremiah L Oyer, Alicja Copik, Griffith D Parks

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002373; DOI: 10.1136/jitc-2021-002373
STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer
Seung Joon Lee, Hannah Yang, Woo Ram Kim, Yu Seong Lee, Won Suk Lee, So Jung Kong, Hye Jin Lee, Jeong Hun Kim, Jaekyung Cheon, Beodeul Kang, Hong Jae Chon, Chan Kim

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002195; DOI: 10.1136/jitc-2020-002195
Transcriptional analysis of multiple ovarian cancer cohorts reveals prognostic and immunomodulatory consequences of ERV expression
Marina Natoli, John Gallon, Haonan Lu, Ala Amgheib, David J Pinato, Francesco A Mauri, Teresa Marafioti, Ayse U Akarca, Ines Ullmo, Jacey Ip, Eric O Aboagye, Robert Brown, Anastasios Karadimitris, Sadaf Ghaem-Maghami

Journal for ImmunoTherapy of Cancer Jan 2021, 9 (1) e001519; DOI: 10.1136/jitc-2020-001519
Mitochondrial Lon-induced mtDNA leakage contributes to PD-L1–mediated immunoescape via STING-IFN signaling and extracellular vesicles
An Ning Cheng, Li-Chun Cheng, Cheng-Liang Kuo, Yu Kang Lo, Han-Yu Chou, Chung-Hsing Chen, Yi-Hao Wang, Tsung-Hsien Chuang, Shih-Jung Cheng, Alan Yueh-Luen Lee

Journal for ImmunoTherapy of Cancer Dec 2020, 8 (2) e001372; DOI: 10.1136/jitc-2020-001372

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