lung neoplasms

Deconvolution of malignant pleural effusions immune landscape unravels a novel macrophage signature associated with worse clinical outcome in lung adenocarcinoma patients
Sara Bruschini, Matteo Pallocca, Eleonora Sperandio, Lorenzo D’Ambrosio, Francesca Ascenzi, Claudia De Vitis, Valentina Salvati, Antonella Esposito, Simona Di Martino, Francesca De Nicola, Francesca Paolini, Luigi Fattore, Gabriele Alessandrini, Francesco Facciolo, Maria Laura Foddai, Massimiliano Bassi, Federico Venuta, Michela D’Ascanio, Alberto Ricci, Antonio D’ Andrilli, Christian Napoli, Luigi Aurisicchio, Maurizio Fanciulli, Erino Angelo Rendina, Gennaro Ciliberto, Rita Mancini

Journal for ImmunoTherapy of Cancer May 2022, 10 (5) e004239; DOI: 10.1136/jitc-2021-004239
Spatial transcriptomics of macrophage infiltration in non-small cell lung cancer reveals determinants of sensitivity and resistance to anti-PD1/PD-L1 antibodies
Mathieu Larroquette, Jean-Philippe Guegan, Benjamin Besse, Sophie Cousin, Maxime Brunet, Sylvestre Le Moulec, François Le Loarer, Christophe Rey, Jean-Charles Soria, Fabrice Barlesi, Alban Bessede, Jean-Yves Scoazec, Isabelle Soubeyran, Antoine Italiano

Journal for ImmunoTherapy of Cancer May 2022, 10 (5) e003890; DOI: 10.1136/jitc-2021-003890
Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of lung cancer and mesothelioma
Ramaswamy Govindan, Charu Aggarwal, Scott J Antonia, Marianne Davies, Steven M Dubinett, Andrea Ferris, Patrick M Forde, Edward B Garon, Sarah B Goldberg, Raffit Hassan, Matthew D Hellmann, Fred R Hirsch, Melissa L Johnson, Shakun Malik, Daniel Morgensztern, Joel W Neal, Jyoti D Patel, David L Rimm, Sarah Sagorsky, Lawrence H Schwartz, Boris Sepesi, Roy S Herbst

Journal for ImmunoTherapy of Cancer May 2022, 10 (5) e003956; DOI: 10.1136/jitc-2021-003956
Correspondence on 'Novel imaging biomarkers predict outcomes in stage III unresectable non-small cell lung cancer treated with chemoradiation and durvalumab' by Jazieh et al
Jieling Zheng, Bin Zhang

Journal for ImmunoTherapy of Cancer May 2022, 10 (5) e004965; DOI: 10.1136/jitc-2022-004965
Clinical significance of plasma-free amino acids and tryptophan metabolites in patients with non-small cell lung cancer receiving PD-1 inhibitor: a pilot cohort study for developing a prognostic multivariate model
Koichi Azuma, Huihui Xiang, Tomoyuki Tagami, Rika Kasajima, Yumiko Kato, Sachise Karakawa, Shinya Kikuchi, Akira Imaizumi, Norikazu Matsuo, Hidenobu Ishii, Takaaki Tokito, Akihiko Kawahara, Kenta Murotani, Tetsuro Sasada, Yohei Miyagi, Tomoaki Hoshino

Journal for ImmunoTherapy of Cancer May 2022, 10 (5) e004420; DOI: 10.1136/jitc-2021-004420
Targeting SNORA38B attenuates tumorigenesis and sensitizes immune checkpoint blockade in non-small cell lung cancer by remodeling the tumor microenvironment via regulation of GAB2/AKT/mTOR signaling pathway
Yue Zhuo, Shujun Li, Wei Hu, Yu Zhang, Yufan Shi, Faxue Zhang, Jian Zhang, Juan Wang, Meijuan Liao, Jiahao Chen, Huiling Qian, Dejia Li, Chengcao Sun

Journal for ImmunoTherapy of Cancer May 2022, 10 (5) e004113; DOI: 10.1136/jitc-2021-004113
Role of tumor infiltrating lymphocytes and spatial immune heterogeneity in sensitivity to PD-1 axis blockers in non-small cell lung cancer
Miguel Lopez de Rodas, Venkata Nagineni, Arvind Ravi, Ila J Datar, Mari Mino-Kenudson, German Corredor, Cristian Barrera, Lindsey Behlman, David L Rimm, Roy S Herbst, Anant Madabhushi, Jonathan W Riess, Vamsidhar Velcheti, Matthew D Hellmann, Justin Gainor, Kurt A Schalper

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004440; DOI: 10.1136/jitc-2021-004440
Longitudinal plasma proteomic profiling of patients with non-small cell lung cancer undergoing immune checkpoint blockade
Michal Harel, Coren Lahav, Eyal Jacob, Nili Dahan, Itamar Sela, Yehonatan Elon, Shani Raveh Shoval, Galit Yahalom, Iris Kamer, Alona Zer, Ofer Sharon, David P Carbone, Adam P Dicker, Jair Bar, Yuval Shaked

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004582; DOI: 10.1136/jitc-2022-004582
Real-world incidence and impact of pneumonitis in patients with lung cancer treated with immune checkpoint inhibitors: a multi-institutional cohort study
Bruce C Tiu, Leyre Zubiri, James Iheke, Vartan Pahalyants, Nicholas Theodosakis, Pearl Ugwu-Dike, Jayhyun Seo, Kimberly Tang, Meghan E Sise, Ryan Sullivan, Jarushka Naidoo, Meghan J Mooradian, Yevgeniy R Semenov, Kerry L Reynolds

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004670; DOI: 10.1136/jitc-2022-004670
Cancer cell-autonomous overactivation of PARP1 compromises immunosurveillance in non-small cell lung cancer
Pan Juncheng, Adrien Joseph, Antoine Lafarge, Isabelle Martins, Florine Obrist, Jonathan Pol, Ester Saavedra, Sijing Li, Allan Sauvat, Giulia Cerrato, Sarah Lévesque, Marion Leduc, Oliver Kepp, Sylvère Durand, Fanny Aprahamian, Nitharsshini Nirmalathansan, Judith Michels, Guido Kroemer, Maria Castedo

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004280; DOI: 10.1136/jitc-2021-004280

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