lymphocytes, tumor-infiltrating

Clinical outcome following checkpoint therapy in renal cell carcinoma is associated with a burst of activated CD8 T cells in blood
Jennifer Wilkinson Carlisle, Caroline S Jansen, Maria Andrea Cardenas, Ewelina Sobierajska, Adriana Moon Reyes, Rachel Greenwald, Luke Del Balzo, Nataliya Prokhnevska, Omer Kucuk, Bradley C Carthon, Patrick Connor Mullane, Adeboye Osunkoya, Deborah Baumgarten, Fares Hosseinzadeh, Scott Wilkinson, Ross Lake, Adam G Sowalsky, Yuan Liu, Viraj A Master, Mehmet A Bilen, Haydn Kissick

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004803; DOI: 10.1136/jitc-2022-004803
Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment
Rita C. Acúrcio, Sabina Pozzi, Barbara Carreira, Marta Pojo, Nuria Gómez-Cebrián, Sandra Casimiro, Adelaide Fernandes, Andreia Barateiro, Vitor Farricha, Joaquim Brito, Ana Paula Leandro, Jorge A R Salvador, Luís Graça, Leonor Puchades-Carrasco, Luís Costa, Ronit Satchi-Fainaro, Rita C. Guedes, Helena F. Florindo

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004695; DOI: 10.1136/jitc-2022-004695
Intrahepatic CD69⁺Vδ1 T cells re-circulate in the blood of patients with metastatic colorectal cancer and limit tumor progression
Elena Bruni, Matteo Maria Cimino, Matteo Donadon, Roberta Carriero, Sara Terzoli, Rocco Piazza, Sarina Ravens, Immo Prinz, Valentina Cazzetta, Paolo Marzano, Paolo Kunderfranco, Clelia Peano, Cristiana Soldani, Barbara Franceschini, Federico Simone Colombo, Cecilia Garlanda, Alberto Mantovani, Guido Torzilli, Joanna Mikulak, Domenico Mavilio

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004579; DOI: 10.1136/jitc-2022-004579
Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses
Yan Lan, Tsz-Lun Yeung, Hui Huang, Ansgar A Wegener, Somdutta Saha, Mira Toister-Achituv, Molly H Jenkins, Li-Ya Chiu, Adam Lazorchak, Ohad Tarcic, Hong Wang, Jin Qi, George Locke, Doron Kalimi, Guozhong Qin, Bo Marelli, Huakui Yu, Alec W Gross, Melissa G Derner, Maria Soloviev, Mathieu Botte, Aroop Sircar, Hong Ma, Vanita D Sood, Dong Zhang, Feng Jiang, Kin-Ming Lo

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004122; DOI: 10.1136/jitc-2021-004122
Preinduced reovirus-specific T-cell immunity enhances the anticancer efficacy of reovirus therapy
Christianne Groeneveldt, Priscilla Kinderman, Jordi J C van Stigt Thans, Camilla Labrie, Lisa Griffioen, Marjolein Sluijter, Diana J M van den Wollenberg, Rob C Hoeben, Joke M M den Haan, Sjoerd H van der Burg, Thorbald van Hall, Nadine van Montfoort

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004464; DOI: 10.1136/jitc-2021-004464
Local and systemic immune profiles of human pancreatic ductal adenocarcinoma revealed by single-cell mass cytometry
Thomas P Brouwer, Natasja L de Vries, Tamim Abdelaal, Ricki T Krog, Zheng Li, Dina Ruano, Arantza Fariña, Boudewijn P F Lelieveldt, Hans Morreau, Bert A Bonsing, Alexander L Vahrmeijer, Frits Koning, Noel F C C de Miranda

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004638; DOI: 10.1136/jitc-2022-004638
Cancer cell-autonomous overactivation of PARP1 compromises immunosurveillance in non-small cell lung cancer
Pan Juncheng, Adrien Joseph, Antoine Lafarge, Isabelle Martins, Florine Obrist, Jonathan Pol, Ester Saavedra, Sijing Li, Allan Sauvat, Giulia Cerrato, Sarah Lévesque, Marion Leduc, Oliver Kepp, Sylvère Durand, Fanny Aprahamian, Nitharsshini Nirmalathansan, Judith Michels, Guido Kroemer, Maria Castedo

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004280; DOI: 10.1136/jitc-2021-004280
Targeting of Nrf2 improves antitumoral responses by human NK cells, TIL and CAR T cells during oxidative stress
Stefanie Renken, Takahiro Nakajima, Isabelle Magalhaes, Jonas Mattsson, Andreas Lundqvist, Elias S J Arnér, Rolf Kiessling, Stina Linnea Wickström

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004458; DOI: 10.1136/jitc-2021-004458
Innate immune receptor signaling induces transient melanoma dedifferentiation while preserving immunogenicity
Beatrice Thier, Fang Zhao, Simone Stupia, Alicia Brüggemann, Johannes Koch, Nina Schulze, Susanne Horn, Christoph Coch, Gunther Hartmann, Antje Sucker, Dirk Schadendorf, Annette Paschen

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e003863; DOI: 10.1136/jitc-2021-003863
Role of tumor infiltrating lymphocytes and spatial immune heterogeneity in sensitivity to PD-1 axis blockers in non-small cell lung cancer
Miguel Lopez de Rodas, Venkata Nagineni, Arvind Ravi, Ila J Datar, Mari Mino-Kenudson, German Corredor, Cristian Barrera, Lindsey Behlman, David L Rimm, Roy S Herbst, Anant Madabhushi, Jonathan W Riess, Vamsidhar Velcheti, Matthew D Hellmann, Justin Gainor, Kurt A Schalper

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004440; DOI: 10.1136/jitc-2021-004440

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