Lymphocytes

Challenges and next steps in the advancement of immunotherapy: summary of the 2018 and 2020 National Cancer Institute workshops on cell-based immunotherapy for solid tumors
Laura K Fogli, Rosemarie Aurigemma, Connie L Sommers, Anju Singh, Kasia Bourcier, Marc S Ernstoff

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e003048; DOI: 10.1136/jitc-2021-003048
Human leukocyte antigen class II-based immune risk model for recurrence evaluation in stage I–III small cell lung cancer
Peixin Chen, Lishu Zhao, Hao Wang, Liping Zhang, Wei Zhang, Jun Zhu, Jia Yu, Sha Zhao, Wei Li, Chenglong Sun, Chunyan Wu, Yayi He, Caicun Zhou

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e002554; DOI: 10.1136/jitc-2021-002554
PI3Kα inhibitor CYH33 triggers antitumor immunity in murine breast cancer by activating CD8⁺T cells and promoting fatty acid metabolism
Pu Sun, Xi Zhang, Rong-Jing Wang, Qing-Yang Ma, Lan Xu, Yi Wang, Hui-Ping Liao, Hai-Long Wang, Lan-Dian Hu, Xiangyin Kong, Jian Ding, Ling-Hua Meng

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e003093; DOI: 10.1136/jitc-2021-003093
Cystathionine β-synthase mediated PRRX2/IL-6/STAT3 inactivation suppresses Tregs infiltration and induces apoptosis to inhibit HCC carcinogenesis
Yu-Fu Zhou, Shu-Shu Song, Meng-Xin Tian, Zheng Tang, Han Wang, Yuan Fang, Wei-Feng Qu, Xi-Fei Jiang, Chen-Yang Tao, Run Huang, Pei-Yun Zhou, Shi-Guo Zhu, Jian Zhou, Jia Fan, Wei-Ren Liu, Ying-Hong Shi

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e003031; DOI: 10.1136/jitc-2021-003031
Genomic profiles and their associations with TMB, PD-L1 expression, and immune cell infiltration landscapes in synchronous multiple primary lung cancers
Chunhong Hu, Lishu Zhao, Wenliang Liu, Songqing Fan, Junqi Liu, Yuxuan Liu, Xiaohan Liu, Long Shu, Xianling Liu, Ping Liu, Chao Deng, Zhenhua Qiu, Chen Chen, Yi Jiang, Qingchun Liang, Lingling Yang, Yang Shao, Qiongzhi He, Danlei Yu, Yue Zeng, Yizheng Li, Yue Pan, Sujuan Zhang, Shenghao Shi, Yurong Peng, Fang Wu

Journal for ImmunoTherapy of Cancer Dec 2021, 9 (12) e003773; DOI: 10.1136/jitc-2021-003773
Genomic and transcriptomic characterization of heterogeneous immune subgroups of microsatellite instability-high colorectal cancers
Jung Ho Kim, Mi-Kyoung Seo, Ji Ae Lee, Seung-Yeon Yoo, Hyeon Jeong Oh, Hyundeok Kang, Nam-Yun Cho, Jeong Mo Bae, Gyeong Hoon Kang, Sangwoo Kim

Journal for ImmunoTherapy of Cancer Dec 2021, 9 (12) e003414; DOI: 10.1136/jitc-2021-003414
Combinatorial immunotherapy induces tumor-infiltrating CD8⁺ T cells with distinct functional, migratory, and stem-like properties
Natalija Van Braeckel-Budimir, Joseph Samuel Dolina, Jie Wei, Xiao Wang, Shih-Hsun Chen, Pamela Santiago, Guanghuan Tu, Luca Micci, Amir A Al-Khami, Sophia Pfister, Sripad Ram, Purnima Sundar, Graham Thomas, Hua Long, Wenjing Yang, Shobha Potluri, Shahram Salek-Ardakani

Journal for ImmunoTherapy of Cancer Dec 2021, 9 (12) e003614; DOI: 10.1136/jitc-2021-003614
Distinct exhaustion features of T lymphocytes shape the tumor-immune microenvironment with therapeutic implication in patients with non-small-cell lung cancer
Chang Gon Kim, Gamin Kim, Kyung Hwan Kim, Seyeon Park, Sunhye Shin, Dahee Yeo, Hyo Sup Shim, Hong In Yoon, Seong Yong Park, Sang-Jun Ha, Hye Ryun Kim

Journal for ImmunoTherapy of Cancer Dec 2021, 9 (12) e002780; DOI: 10.1136/jitc-2021-002780
Early disappearance of tumor antigen-reactive T cells from peripheral blood correlates with superior clinical outcomes in melanoma under anti-PD-1 therapy
Jonas Bochem, Henning Zelba, Janine Spreuer, Teresa Amaral, Nikolaus B Wagner, Andrea Gaissler, Oltin T Pop, Karolin Thiel, Can Yurttas, Daniel Soffel, Stephan Forchhammer, Tobias Sinnberg, Heike Niessner, Friedegund Meier, Patrick Terheyden, Alfred Königsrainer, Claus Garbe, Lukas Flatz, Graham Pawelec, Thomas K Eigentler, Markus W Löffler, Benjamin Weide, Kilian Wistuba-Hamprecht

Journal for ImmunoTherapy of Cancer Dec 2021, 9 (12) e003439; DOI: 10.1136/jitc-2021-003439
Type 17 immunity promotes the exhaustion of CD8⁺ T cells in cancer
Byung-Seok Kim, Da-Sol Kuen, Choong-Hyun Koh, Hyung-Don Kim, Seon Hee Chang, Sehui Kim, Yoon Kyung Jeon, Young-Jun Park, Garam Choi, Jiyeon Kim, Keon Wook Kang, Hye Young Kim, Suk-Jo Kang, Shin Hwang, Eui-Cheol Shin, Chang-Yuil Kang, Chen Dong, Yeonseok Chung

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002603; DOI: 10.1136/jitc-2021-002603

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