Macrophages

Intratumoral combination therapy with poly(I:C) and resiquimod synergistically triggers tumor-associated macrophages for effective systemic antitumoral immunity
Clément Anfray, Francesco Mainini, Elisabeth Digifico, Akihiro Maeda, Marina Sironi, Marco Erreni, Achille Anselmo, Aldo Ummarino, Sara Gandoy, Francisco Expósito, Miriam Redrado, Diego Serrano, Alfonso Calvo, Marvin Martens, Susana Bravo, Alberto Mantovani, Paola Allavena, Fernando Torres Andón

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002408; DOI: 10.1136/jitc-2021-002408
Matter of TIME: the tumor-immune microenvironment of mesothelioma and implications for checkpoint blockade efficacy
James Harber, Tamihiro Kamata, Catrin Pritchard, Dean Fennell

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e003032; DOI: 10.1136/jitc-2021-003032
CD4+ T cell and M2 macrophage infiltration predict dedifferentiated liposarcoma patient outcomes
Brett A Schroeder, Natalie A LaFranzo, Bonnie J LaFleur, Rachel M Gittelman, Marissa Vignali, Shihong Zhang, Kevin C Flanagan, Julie Rytlewski, Laura Riolobos, Brian C Schulte, Teresa S Kim, Eleanor Chen, Kimberly S Smythe, Michael J Wagner, Jose G Mantilla, Jean S Campbell, Robert H Pierce, Robin L Jones, Lee D Cranmer, Seth M Pollack

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e002812; DOI: 10.1136/jitc-2021-002812
CARs and beyond: tailoring macrophage-based cell therapeutics to combat solid malignancies
Shifaa M. Abdin, Daniela Paasch, Michael Morgan, Nico Lachmann

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e002741; DOI: 10.1136/jitc-2021-002741
PI3Kα inhibitor CYH33 triggers antitumor immunity in murine breast cancer by activating CD8⁺T cells and promoting fatty acid metabolism
Pu Sun, Xi Zhang, Rong-Jing Wang, Qing-Yang Ma, Lan Xu, Yi Wang, Hui-Ping Liao, Hai-Long Wang, Lan-Dian Hu, Xiangyin Kong, Jian Ding, Ling-Hua Meng

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e003093; DOI: 10.1136/jitc-2021-003093
p38 MAPK signaling in M1 macrophages results in selective elimination of M2 macrophages by MEK inhibition
Daniel Baumann, Jennifer Drebant, Tanja Hägele, Luisa Burger, Clara Serger, Claudia Lauenstein, Przemyslaw Dudys, Gerrit Erdmann, Rienk Offringa

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002319; DOI: 10.1136/jitc-2020-002319
S100A4 enhances protumor macrophage polarization by control of PPAR-γ-dependent induction of fatty acid oxidation
Shuangqing Liu, Huilei Zhang, Yanan Li, Yana Zhang, Yangyang Bian, Yanqiong Zeng, Xiaohan Yao, Jiajia Wan, Xu Chen, Jianru Li, Zhaoqing Wang, Zhihai Qin

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002548; DOI: 10.1136/jitc-2021-002548
IL-6 contributes to metastatic switch via the differentiation of monocytic-dendritic progenitors into prometastatic immune cells
Ksenia Magidey-Klein, Tim J Cooper, Ksenya Kveler, Rachelly Normand, Tongwu Zhang, Michael Timaner, Ziv Raviv, Brian P. James, Roi Gazit, Ze'ev A. Ronai, Shai Shen-Orr, Yuval Shaked

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002856; DOI: 10.1136/jitc-2021-002856
Mesoporous silica nanoparticles inflame tumors to overcome anti-PD-1 resistance through TLR4-NFκB axis
Mayu Sun, Pengfei Gu, Yang Yang, Luodan Yu, Zheshun Jiang, Jingquan Li, Yingying Le, Yu Chen, Qian Ba, Hui Wang

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002508; DOI: 10.1136/jitc-2021-002508
IL-6 signaling in macrophages is required for immunotherapy-driven regression of tumors
Elham Beyranvand Nejad, Camilla Labrie, Marit J van Elsas, Jan Willem Kleinovink, Hans-Willi Mittrücker, Kees L M C Franken, Sylvia Heink, Thomas Korn, Ramon Arens, Thorbald van Hall, Sjoerd H van der Burg

Journal for ImmunoTherapy of Cancer Apr 2021, 9 (4) e002460; DOI: 10.1136/jitc-2021-002460

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