Macrophages

GPC2 antibody–drug conjugate reprograms the neuroblastoma immune milieu to enhance macrophage-driven therapies
Guillem Pascual-Pasto, Brendan McIntyre, Rawan Shraim, Samantha N Buongervino, Amy K Erbe, Doncho V Zhelev, Shakhnozakhon Sadirova, Anna M Giudice, Daniel Martinez, Laura Garcia-Gerique, Dimiter S Dimitrov, Paul M Sondel, Kristopher R Bosse

Journal for ImmunoTherapy of Cancer Dec 2022, 10 (12) e004704; DOI: 10.1136/jitc-2022-004704
Targeting CD89 on tumor-associated macrophages overcomes resistance to immune checkpoint blockade
Lijun Xu, Bingyu Li, Chenyu Pi, Zhaohua Zhu, Fei Tao, Kun Xie, Yan Feng, Xiaoqing Xu, Yanxin Yin, Hua Gu, Jianmin Fang

Journal for ImmunoTherapy of Cancer Dec 2022, 10 (12) e005447; DOI: 10.1136/jitc-2022-005447
Antitumor strategies targeting macrophages: the importance of considering the differences in differentiation/polarization processes between human and mouse macrophages
Marine Monnier, Léa Paolini, Emeline Vinatier, Alberto Mantovani, Yves Delneste, Pascale Jeannin

Journal for ImmunoTherapy of Cancer Oct 2022, 10 (10) e005560; DOI: 10.1136/jitc-2022-005560
Local TLR4 stimulation augments in situ vaccination induced via local radiation and anti-CTLA-4 checkpoint blockade through induction of CD8 T-cell independent Th1 polarization
Justin C Jagodinsky, Amber M Bates, Paul A Clark, Raghava N Sriramaneni, Thomas C Havighurst, Ishan Chakravarty, Erin J Nystuen, KyungMann Kim, Paul M Sondel, Won Jong Jin, Zachary S Morris

Journal for ImmunoTherapy of Cancer Oct 2022, 10 (10) e005103; DOI: 10.1136/jitc-2022-005103
Ironing out exercise on immuno-oncological outcomes
Janjira Soh, Zi Xiang Lim, Elaine Hsuen Lim, Brian K Kennedy, Jorming Goh

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e002976; DOI: 10.1136/jitc-2021-002976
Combination of a novel heat shock protein 90-targeted photodynamic therapy with PD-1/PD-L1 blockade induces potent systemic antitumor efficacy and abscopal effect against breast cancers
Kensuke Kaneko, Chaitanya R Acharya, Hiroshi Nagata, Xiao Yang, Zachary Conrad Hartman, Amy Hobeika, Philip F Hughes, Timothy A J Haystead, Michael A Morse, Herbert Kim Lyerly, Takuya Osada

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e004793; DOI: 10.1136/jitc-2022-004793
BND-22, a first-in-class humanized ILT2-blocking antibody, promotes antitumor immunity and tumor regression
Ilana Mandel, Dana Haves Ziv, Ilana Goldshtein, Tsuri Peretz, Dror Alishekevitz, Anna Fridman Dror, Motti Hakim, Sharon Hashmueli, Itay Friedman, Yair Sapir, Rita Greco, Hongjing Qu, Frank Nestle, Dmitri Wiederschain, Lily Pao, Sharad Sharma, Tehila Ben Moshe

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e004859; DOI: 10.1136/jitc-2022-004859
Unveiling the tumor immune microenvironment of organ-specific melanoma metastatic sites
Jordan W Conway, Robert V Rawson, Serigne Lo, Tasnia Ahmed, Ismael A Vergara, Tuba N Gide, Grace Heloise Attrill, Matteo S Carlino, Robyn P M Saw, John F Thompson, Andrew J Spillane, Kerwin F Shannon, Brindha Shivalingam, Alexander Maxwell Menzies, James S Wilmott, Georgina V Long, Richard A Scolyer, Ines Pires da Silva

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e004884; DOI: 10.1136/jitc-2022-004884
LRIG2 promotes glioblastoma progression by modulating innate antitumor immunity through macrophage infiltration and polarization
Jinyang Hu, Feng Dong, You He, Xianyou Xia, Fangling Cheng, Sui Chen, Xiaoshuang Hou, Po Zhang, Guohao Liu, Ying Li, Qian Gao, Minhai Dong, Ting Li, Wei Li, Qungen Xiao, Xiaopeng Li, Xingjiang Yu, Guifa Xi, Dongsheng Guo, Xudong Wu, Baofeng Wang

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e004452; DOI: 10.1136/jitc-2021-004452
Snail-regulated exosomal microRNA-21 suppresses NLRP3 inflammasome activity to enhance cisplatin resistance
Han-Ying Cheng, Chia-Hsin Hsieh, Po-Han Lin, Yu-Tung Chen, Dennis Shin-Shian Hsu, Shyh-Kuan Tai, Pen-Yuan Chu, Muh-Hwa Yang

Journal for ImmunoTherapy of Cancer Aug 2022, 10 (8) e004832; DOI: 10.1136/jitc-2022-004832

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