Macrophages

Local IFNα enhances the anti-tumoral efficacy of systemic anti-PD1 to prevent tumor relapse
Marion v Guerin, Fabienne Regnier, Maxime Thoreau, Lene Vimeux, Matthieu Benard, Estelle Dransart, Hweixian L Penny, Ludger Johannes, Alain Trautmann, Nadege Bercovici

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (2) e000996; DOI: 10.1136/jitc-2020-000996
Wrinkle in the plan: miR-34a-5p impacts chemokine signaling by modulating CXCL10/CXCL11/CXCR3-axis in CD4⁺, CD8⁺ T cells, and M1 macrophages
Martin Hart, Laura Nickl, Barbara Walch-Rueckheim, Lena Krammes, Stefanie Rheinheimer, Caroline Diener, Tanja Taenzer, Tim Kehl, Martina Sester, Hans-Peter Lenhof, Andreas Keller, Eckart Meese

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (2) e001617; DOI: 10.1136/jitc-2020-001617
Combination of gemcitabine and anti-PD-1 antibody enhances the anticancer effect of M1 macrophages and the Th1 response in a murine model of pancreatic cancer liver metastasis
Tuyen Thuy Bich Ho, Alessandro Nasti, Akihiro Seki, Takuya Komura, Hiiro Inui, Takashi Kozaka, Yoji Kitamura, Kazuhiro Shiba, Taro Yamashita, Tatsuya Yamashita, Eishiro Mizukoshi, Kazunori Kawaguchi, Takashi Wada, Masao Honda, Shuichi Kaneko, Yoshio Sakai

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (2) e001367; DOI: 10.1136/jitc-2020-001367
Human macrophages engineered to secrete a bispecific T cell engager support antigen-dependent T cell responses to glioblastoma
Jennifer L Gardell, Lisa R Matsumoto, Harrison Chinn, Kole R DeGolier, Shannon A Kreuser, Brooke Prieskorn, Stephanie Balcaitis, Amira Davis, Richard G Ellenbogen, Courtney A Crane

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e001202; DOI: 10.1136/jitc-2020-001202
PD-1 inhibitor inducing exosomal miR-34a-5p expression mediates the cross talk between cardiomyocyte and macrophage in immune checkpoint inhibitor–related cardiac dysfunction
Wenzheng Xia, Hanbin Chen, Didi Chen, Yijia Ye, Congying Xie, Meng Hou

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e001293; DOI: 10.1136/jitc-2020-001293
Genetically engineered macrophages persist in solid tumors and locally deliver therapeutic proteins to activate immune responses
Katherine J Brempelis, Courtney M Cowan, Shannon A Kreuser, Kevin P Labadie, Brooke M Prieskorn, Nicole A P Lieberman, Chibawanye I Ene, Kara W Moyes, Harrison Chinn, Kole R DeGolier, Lisa R Matsumoto, Sara K Daniel, Jason K Yokoyama, Amira D Davis, Virginia J Hoglund, Kimberly S Smythe, Stephanie D Balcaitis, Michael C Jensen, Richard G Ellenbogen, Jean S Campbell, Robert H Pierce, Eric C Holland, Venu G Pillarisetty, Courtney A Crane

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e001356; DOI: 10.1136/jitc-2020-001356
CD47/SIRPα blocking peptide identification and synergistic effect with irradiation for cancer immunotherapy
Hongfei Wang, Yixuan Sun, Xiuman Zhou, Chunxia Chen, Ling Jiao, Wanqiong Li, Shanshan Gou, Yanying Li, Jiangfeng Du, Guanyu Chen, Wenjie Zhai, Yahong Wu, Yuanming Qi, Yanfeng Gao

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e000905; DOI: 10.1136/jitc-2020-000905
Targeted delivery of miR-99b reprograms tumor-associated macrophage phenotype leading to tumor regression
Liang Wang, Yi-Yang Hu, Jun-Long Zhao, Fei Huang, Shi-Qian Liang, Lei Dong, Yan Chen, Heng-Chao Yu, Jian Bai, Jia-Meng Yang, Jie-Yi Fan, Lei Feng, San-Zhong Li, Hua Han, Hong-Yan Qin

Journal for ImmunoTherapy of Cancer Sep 2020, 8 (2) e000517; DOI: 10.1136/jitc-2019-000517
Immunohistochemical scoring of CD38 in the tumor microenvironment predicts responsiveness to anti-PD-1/PD-L1 immunotherapy in hepatocellular carcinoma
Harry Ho Man Ng, Ren Yuan Lee, Siting Goh, Isabel Shu Ying Tay, Xinru Lim, Bernett Lee, Valerie Chew, Huihua Li, Benedict Tan, Sherlly Lim, Jeffrey Chun Tatt Lim, Bijin Au, Josh Jie Hua Loh, Sahil Saraf, John Edward Connolly, Tracy Loh, Wei Qiang Leow, Joycelyn Jie Xin Lee, Han Chong Toh, Fabio Malavasi, Ser Yee Lee, Pierce Chow, Evan W Newell, Su Pin Choo, David Tai, Joe Yeong, Tony Kiat Hon Lim

Journal for ImmunoTherapy of Cancer Aug 2020, 8 (2) e000987; DOI: 10.1136/jitc-2020-000987
M2-like macrophages dictate clinically relevant immunosuppression in metastatic ovarian cancer
Michal Hensler, Lenka Kasikova, Karel Fiser, Jana Rakova, Petr Skapa, Jan Laco, Tereza Lanickova, Ladislav Pecen, Iva Truxova, Sarka Vosahlikova, Irena Moserova, Ivan Praznovec, Vit Drochytek, Martina Rehackova, Tomas Brtnicky, Lukas Rob, Vladimir Benes, Jelena Pistolic, Ludek Sojka, Ales Ryska, Catherine Sautes-Fridman, Wolf Herve Fridman, Lorenzo Galluzzi, Radek Spisek, Jitka Fucikova

Journal for ImmunoTherapy of Cancer Aug 2020, 8 (2) e000979; DOI: 10.1136/jitc-2020-000979

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