Melanoma

Nanoparticle delivery of miR-21-3p sensitizes melanoma to anti-PD-1 immunotherapy by promoting ferroptosis
Weinan Guo, Zhenjie Wu, Jianru Chen, Sen Guo, Weiming You, Sijia Wang, Jinyuan Ma, Huina Wang, Xiangxu Wang, Hao Wang, Jingjing Ma, Yuqi Yang, Yangzi Tian, Qiong Shi, Tianwen Gao, Xiuli Yi, Chunying Li

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004381; DOI: 10.1136/jitc-2021-004381
BCG hydrogel promotes CTSS-mediated antigen processing and presentation, thereby suppressing metastasis and prolonging survival in melanoma
Mirela Kremenovic, Alfred A Chan, Bing Feng, Lukas Bäriswyl, Steve Robatel, Thomas Gruber, Li Tang, Delphine J Lee, Mirjam Schenk

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004133; DOI: 10.1136/jitc-2021-004133
Spartalizumab or placebo in combination with dabrafenib and trametinib in patients with BRAF V600-mutant melanoma: exploratory biomarker analyses from a randomized phase 3 trial (COMBI-i)
Hussein A Tawbi, Caroline Robert, Jan C Brase, Daniel Gusenleitner, Eduard Gasal, James Garrett, Alexander Savchenko, Güllü Görgün, Keith T Flaherty, Antoni Ribas, Reinhard Dummer, Dirk Schadendorf, Georgina V Long, Paul D Nathan, Paolo A Ascierto

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004226; DOI: 10.1136/jitc-2021-004226
Innate immune receptor signaling induces transient melanoma dedifferentiation while preserving immunogenicity
Beatrice Thier, Fang Zhao, Simone Stupia, Alicia Brüggemann, Johannes Koch, Nina Schulze, Susanne Horn, Christoph Coch, Gunther Hartmann, Antje Sucker, Dirk Schadendorf, Annette Paschen

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e003863; DOI: 10.1136/jitc-2021-003863
Impact of radiotherapy and sequencing of systemic therapy on survival outcomes in melanoma patients with previously untreated brain metastasis: a multicenter DeCOG study on 450 patients from the prospective skin cancer registry ADOREG
Cindy Franklin, Peter Mohr, Leonie Bluhm, Imke Grimmelmann, Ralf Gutzmer, Friedegund Meier, Marlene Garzarolli, Michael Weichenthal, Claudia Pfoehler, Rudolf Herbst, Patrick Terheyden, Jochen Utikal, Jens Ulrich, Dirk Debus, Sebastian Haferkamp, Martin Kaatz, Andrea Forschner, Ulrike Leiter, Dorothee Nashan, Alexander Kreuter, Michael Sachse, Julia Welzel, Lucie Heinzerling, Frank Meiss, Carsten Weishaupt, Thilo Gambichler, Gerhard Weyandt, Edgar Dippel, Kerstin Schatton, Eren Celik, Maike Trommer, Iris Helfrich, Alexander Roesch, Lisa Zimmer, Elisabeth Livingstone, Dirk Schadendorf, Susanne Horn, Selma Ugurel

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004509; DOI: 10.1136/jitc-2022-004509
Higher proportions of CD39+ tumor-resident cytotoxic T cells predict recurrence-free survival in patients with stage III melanoma treated with adjuvant immunotherapy
Grace Heloise Attrill, Carina N Owen, Tasnia Ahmed, Ismael A Vergara, Andrew J Colebatch, Jordan W Conway, Kazi J Nahar, John F Thompson, Ines Pires da Silva, Matteo S Carlino, Alexander M Menzies, Serigne Lo, Umaimainthan Palendira, Richard A Scolyer, Georgina V Long, James S Wilmott

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004771; DOI: 10.1136/jitc-2022-004771
Inhaled recombinant human IL-15 in dogs with naturally occurring pulmonary metastases from osteosarcoma or melanoma: a phase 1 study of clinical activity and correlates of response
Robert B Rebhun, Daniel York, Sylvia Margret Cruz, Sean J Judge, Aryana M Razmara, Lauren E Farley, Rachel V Brady, Eric G Johnson, Jenna H Burton, Jennifer Willcox, Luke A Wittenburg, Kevin Woolard, Cordelia Dunai, Susan L Stewart, Ellen E Sparger, Sita S Withers, Alicia A Gingrich, Katherine A Skorupski, Sami Al-Nadaf, Amandine T LeJeune, William TN Culp, William J Murphy, Michael S Kent, Robert J Canter

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004493; DOI: 10.1136/jitc-2022-004493
Durable and dynamic hTERT immune responses following vaccination with the long-peptide cancer vaccine UV1: long-term follow-up of three phase I clinical trials
Espen Basmo Ellingsen, Elin Aamdal, Tormod Guren, Wolfgang Lilleby, Paal F Brunsvig, Sara M Mangsbo, Steinar Aamdal, Eivind Hovig, Nadia Mensali, Gustav Gaudernack, Else Marit Inderberg

Journal for ImmunoTherapy of Cancer May 2022, 10 (5) e004345; DOI: 10.1136/jitc-2021-004345
Tumor-associated Tregs obstruct antitumor immunity by promoting T cell dysfunction and restricting clonal diversity in tumor-infiltrating CD8+ T cells
David Noyes, Arup Bag, Saheed Oseni, Jon Semidey-Hurtado, Ling Cen, Amod A Sarnaik, Vernon K Sondak, Dennis Adeegbe

Journal for ImmunoTherapy of Cancer May 2022, 10 (5) e004605; DOI: 10.1136/jitc-2022-004605
Antigen mimicry as an effective strategy to induce CSPG4-targeted immunity in dogs with oral melanoma: a veterinary trial
Federica Riccardo, Lidia Tarone, Mariateresa Camerino, Davide Giacobino, Selina Iussich, Giuseppina Barutello, Maddalena Arigoni, Laura Conti, Elisabetta Bolli, Elena Quaglino, Irene Fiore Merighi, Emanuela Morello, Alfredo Dentini, Soldano Ferrone, Paolo Buracco, Federica Cavallo

Journal for ImmunoTherapy of Cancer May 2022, 10 (5) e004007; DOI: 10.1136/jitc-2021-004007

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