natural killer T-cells

Exploiting off-target effects of estrogen deprivation to sensitize estrogen receptor negative breast cancer to immune killing
Benjamin Wolfson, Michelle R Padget, Jeffrey Schlom, James W Hodge

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002258; DOI: 10.1136/jitc-2020-002258
Sensitizing tumors to anti-PD-1 therapy by promoting NK and CD8+ T cells via pharmacological activation of FOXO3
Young Min Chung, Pragya P Khan, Hong Wang, Wen-Bin Tsai, Yanli Qiao, Bo Yu, James W Larrick, Mickey C-T Hu

Journal for ImmunoTherapy of Cancer Dec 2021, 9 (12) e002772; DOI: 10.1136/jitc-2021-002772
Checkpoint blockade accelerates a novel switch from an NKT-driven TNFα response toward a T cell driven IFN-γ response within the tumor microenvironment
Shota Aoyama, Ryosuke Nakagawa, Satoshi Nemoto, Patricio Perez-Villarroel, James J Mulé, Adam William Mailloux

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002269; DOI: 10.1136/jitc-2020-002269
Natural killer T cell immunotherapy combined with oncolytic vesicular stomatitis virus or reovirus treatments differentially increases survival in mouse models of ovarian and breast cancer metastasis
Simon Gebremeskel, Adam Nelson, Brynn Walker, Tora Oliphant, Lynnea Lobert, Douglas Mahoney, Brent Johnston

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e002096; DOI: 10.1136/jitc-2020-002096
GD2 redirected CAR T and activated NK-cell-mediated secretion of IFNγ overcomes MYCN-dependent IDO1 inhibition, contributing to neuroblastoma cell immune escape
Matteo Caforio, Cristina Sorino, Ignazio Caruana, Gerrit Weber, Antonio Camera, Loredana Cifaldi, Biagio De Angelis, Francesca Del Bufalo, Alessia Vitale, Bianca Maria Goffredo, Rita De Vito, Doriana Fruci, Concetta Quintarelli, Maurizio Fanciulli, Franco Locatelli, Valentina Folgiero

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e001502; DOI: 10.1136/jitc-2020-001502
NKTR-255, a novel polymer-conjugated rhIL-15 with potent antitumor efficacy
Takahiro Miyazaki, Mekhala Maiti, Marlene Hennessy, Thomas Chang, Peiwen Kuo, Murali Addepalli, Palakshi Obalapur, Sara Sheibani, Joanna Wilczek, Rhoneil Pena, Phi Quach, Janet Cetz, Andrew Moffett, Yinyan Tang, Peter Kirk, Jicai Huang, Dawei Sheng, Ping Zhang, Werner Rubas, Loui Madakamutil, Saul Kivimäe, Jonathan Zalevsky

Journal for ImmunoTherapy of Cancer May 2021, 9 (5) e002024; DOI: 10.1136/jitc-2020-002024
Immunogenicity of cell death driven by immune effectors
Lorenzo Galluzzi, Giulia Petroni, Guido Kroemer

Journal for ImmunoTherapy of Cancer Apr 2020, 8 (1) e000802; DOI: 10.1136/jitc-2020-000802
Functional and mechanistic advantage of the use of a bifunctional anti-PD-L1/IL-15 superagonist
Karin M Knudson, Kristin C Hicks, Yohei Ozawa, Jeffrey Schlom, Sofia R Gameiro

Journal for ImmunoTherapy of Cancer Apr 2020, 8 (1) e000493; DOI: 10.1136/jitc-2019-000493
Improving selection of patients with metastatic colorectal cancer to benefit from cetuximab based on KIR genotypes
Barbara Manzanares-Martin, Arancha Cebrián Aranda, Laura del Puerto-Nevado, Rafael González, Sonia Solanes, Maria Auxiliadora Gómez-España, Jesús García-Foncillas, Enrique Aranda

Journal for ImmunoTherapy of Cancer Apr 2021, 9 (4) e001705; DOI: 10.1136/jitc-2020-001705
Short-course IL-15 given as a continuous infusion led to a massive expansion of effective NK cells: implications for combination therapy with antitumor antibodies
Sigrid P Dubois, Milos D Miljkovic, Thomas A Fleisher, Stefania Pittaluga, Jennifer Hsu-Albert, Bonita R Bryant, Michael N Petrus, Liyanage P Perera, Jürgen R Müller, Joanna H Shih, Thomas A Waldmann, Kevin C Conlon

Journal for ImmunoTherapy of Cancer Apr 2021, 9 (4) e002193; DOI: 10.1136/jitc-2020-002193

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