Neuroblastoma

Interaction between tumor cell TNFR2 and monocyte membrane-bound TNF-α triggers tumorigenic inflammation in neuroblastoma
Julie A Tomolonis, Xin Xu, Kshiti H Dholakia, Chunchao Zhang, Linjie Guo, Amy N Courtney, Siyue Wang, Julien Balzeau, Gabriel A Barragán, Gengwen Tian, Erica J Di Pierro, Leonid S Metelitsa

Journal for ImmunoTherapy of Cancer Mar 2023, 11 (3) e005478; DOI: 10.1136/jitc-2022-005478
GPC2 antibody–drug conjugate reprograms the neuroblastoma immune milieu to enhance macrophage-driven therapies
Guillem Pascual-Pasto, Brendan McIntyre, Rawan Shraim, Samantha N Buongervino, Amy K Erbe, Doncho V Zhelev, Shakhnozakhon Sadirova, Anna M Giudice, Daniel Martinez, Laura Garcia-Gerique, Dimiter S Dimitrov, Paul M Sondel, Kristopher R Bosse

Journal for ImmunoTherapy of Cancer Dec 2022, 10 (12) e004704; DOI: 10.1136/jitc-2022-004704
Epigenetic modulation of neuroblastoma enhances T cell and NK cell immunogenicity by inducing a tumor-cell lineage switch
Annelisa M Cornel, Ester Dunnebach, Damon A Hofman, Sanjukta Das, Satyaki Sengupta, Femke van den Ham, Judith Wienke, Josephine G M Strijker, Denise A M H van den Beemt, Anke H W Essing, Bianca Koopmans, Sem A G Engels, Vania Lo Presti, Celina S Szanto, Rani E George, Jan J Molenaar, Sebastiaan van Heesch, Miranda P Dierselhuis, S Nierkens

Journal for ImmunoTherapy of Cancer Dec 2022, 10 (12) e005002; DOI: 10.1136/jitc-2022-005002
KIR/KIR-ligand genotypes and clinical outcomes following chemoimmunotherapy in patients with relapsed or refractory neuroblastoma: a report from the Children’s Oncology Group
Amy K Erbe, Mitch B Diccianni, Rajen Mody, Arlene Naranjo, Fan F Zhang, Jen Birstler, KyungMann Kim, Arika S Feils, Jung-Tung Hung, Wendy B London, Barry L Shulkin, Varsha Mathew, Marguerite T Parisi, Sabah Servaes, Shahab Asgharzadeh, John M Maris, Julie Park, Alice L Yu, Paul M Sondel, Rochelle Bagatell

Journal for ImmunoTherapy of Cancer Feb 2023, 11 (2) e006530; DOI: 10.1136/jitc-2022-006530
Anti-GD2 IgA kills tumors by neutrophils without antibody-associated pain in the preclinical treatment of high-risk neuroblastoma
Mitchell Evers, Marjolein Stip, Kaylee Keller, Hanneke Willemen, Maaike Nederend, Marco Jansen, Chilam Chan, Kevin Budding, Stefan Nierkens, Thomas Valerius, Friederike Meyer-Wentrup, Niels Eijkelkamp, Jeanette Leusen

Journal for ImmunoTherapy of Cancer Oct 2021, 9 (10) e003163; DOI: 10.1136/jitc-2021-003163
Small extracellular vesicles induce resistance to anti-GD2 immunotherapy unveiling tipifarnib as an adjunct to neuroblastoma immunotherapy
Xiaoming Liu, Carson A Wills, Longgui Chen, Jiawen Zhang, Yuanjun Zhao, Mi Zhou, Jeffrey M Sundstrom, Todd Schell, Vladimir S Spiegelman, Megan M Young, Hong-Gang Wang

Journal for ImmunoTherapy of Cancer Apr 2022, 10 (4) e004399; DOI: 10.1136/jitc-2021-004399
Single-cell transcriptomics reveals shared immunosuppressive landscapes of mouse and human neuroblastoma
Ana Costa, Cécile Thirant, Amira Kramdi, Cécile Pierre-Eugène, Caroline Louis-Brennetot, Orphée Blanchard, Didier Surdez, Nadege Gruel, Eve Lapouble, Gaëlle Pierron, Deborah Sitbon, Hervé Brisse, Arnaud Gauthier, Paul Fréneaux, Mylène Bohec, Virginie Raynal, Sylvain Baulande, Renaud Leclere, Gabriel Champenois, Andre Nicolas, Didier Meseure, Angela Bellini, Aurelien Marabelle, Birgit Geoerger, Fatima Mechta-Grigoriou, Gudrun Schleiermacher, Laurie Menger, Olivier Delattre, Isabelle Janoueix-Lerosey

Journal for ImmunoTherapy of Cancer Aug 2022, 10 (8) e004807; DOI: 10.1136/jitc-2022-004807
Immunogenomic determinants of tumor microenvironment correlate with superior survival in high-risk neuroblastoma
Riyue Bao, Stefani Spranger, Kyle Hernandez, Yuanyuan Zha, Peter Pytel, Jason J Luke, Thomas F Gajewski, Samuel L Volchenboum, Susan L Cohn, Ami V Desai

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002417; DOI: 10.1136/jitc-2021-002417
GD2-directed bispecific trifunctional antibody outperforms dinutuximab beta in a murine model for aggressive metastasized neuroblastoma
Felix Zirngibl, Sara M Ivasko, Laura Grunewald, Anika Klaus, Silke Schwiebert, Peter Ruf, Horst Lindhofer, Kathy Astrahantseff, Lena Andersch, Johannes H Schulte, Holger N Lode, Angelika Eggert, Kathleen Anders, Patrick Hundsdoerfer, Annette Künkele

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002923; DOI: 10.1136/jitc-2021-002923
Combinatorial immunotherapy of N-803 (IL-15 superagonist) and dinutuximab with ex vivo expanded natural killer cells significantly enhances in vitro cytotoxicity against GD2⁺ pediatric solid tumors and in vivo survival of xenografted immunodeficient NSG mice
Yaya Chu, Gaurav Nayyar, Susiyan Jiang, Jeremy M. Rosenblum, Patrick Soon-Shiong, Jeffrey T Safrit, Dean A. Lee, Mitchell S. Cairo

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002267; DOI: 10.1136/jitc-2020-002267

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