Preclinical

GB1275, a first-in-class CD11b modulator: rationale for immunotherapeutic combinations in solid tumors
David G DeNardo, Anna Galkin, Jakob Dupont, Lei Zhou, Johanna Bendell

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e003005; DOI: 10.1136/jitc-2021-003005
Do the benefits of being a smoker hint at the existence of PD-1/PD-L1 sensitizers for patients on single-agent immunotherapy?
Gintaras Zaleskis, Vita Pasukoniene, Dainius Characiejus, Vincas Urbonas

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e003191; DOI: 10.1136/jitc-2021-003191
Src/lck inhibitor dasatinib reversibly switches off cytokine release and T cell cytotoxicity following stimulation with T cell bispecific antibodies
Gabrielle Leclercq, Hélène Haegel, Anneliese Schneider, Anna Maria Giusti, Estelle Marrer-Berger, Christophe Boetsch, Antje-Christine Walz, Vesna Pulko, Johannes Sam, John Challier, Cristiano Ferlini, Alex Odermatt, Pablo Umaña, Marina Bacac, Christian Klein

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002582; DOI: 10.1136/jitc-2021-002582
p38 MAPK signaling in M1 macrophages results in selective elimination of M2 macrophages by MEK inhibition
Daniel Baumann, Jennifer Drebant, Tanja Hägele, Luisa Burger, Clara Serger, Claudia Lauenstein, Przemyslaw Dudys, Gerrit Erdmann, Rienk Offringa

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002319; DOI: 10.1136/jitc-2020-002319
Oral SMEDDS promotes lymphatic transport and mesenteric lymph nodes target of chlorogenic acid for effective T-cell antitumor immunity
Jun Ye, Yue Gao, Ming Ji, Yanfang Yang, Zhaohui Wang, Baolian Wang, Jing Jin, Ling Li, Hongliang Wang, Xiaoyan Xu, Hengfeng Liao, Chunfang Lian, Yaqi Xu, Renjie Li, Tong Sun, Lili Gao, Yan Li, Xiaoguang Chen, Yuling Liu

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002753; DOI: 10.1136/jitc-2021-002753
Metformin generates profound alterations in systemic and tumor immunity with associated antitumor effects
Ratna Veeramachaneni, Wangjie Yu, Jared M Newton, Jan O Kemnade, Heath D Skinner, Andrew G Sikora, Vlad C Sandulache

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002773; DOI: 10.1136/jitc-2021-002773
Determinants of response to daratumumab in Epstein-Barr virus-positive natural killer and T-cell lymphoma
Nurulhuda Mustafa, Adina Huey Fang Nee, Jing Yuan Chooi, Sabrina Hui Min Toh, Tae-Hoon Chung, Viknesvaran Selvarajan, Shuangyi Fan, Siok Bian Ng, Michelle Poon, Esther Chan, Joanne Lee, Yen Lin Chee, Anand D Jeyasekharan, Longen Zhou, Jennifer Yang, Wee Joo Chng

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002123; DOI: 10.1136/jitc-2020-002123
Novel non-terminal tumor sampling procedure using fine needle aspiration supports immuno-oncology biomarker discovery in preclinical mouse models
Suzanne Isabelle Sitnikova, Sophie Munnings-Tomes, Elena Galvani, Stacy Kentner, Kathy Mulgrew, Chris Rands, Judit España Agustí, Tianhui Zhang, Kristina M Ilieva, Guglielmo Rosignoli, Hormas Ghadially, Matthew J Robinson, Tim Slidel, Robert W Wilkinson, Simon J Dovedi

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002894; DOI: 10.1136/jitc-2021-002894
CD122-directed interleukin-2 treatment mechanisms in bladder cancer differ from αPD-L1 and include tissue-selective γδ T cell activation
Ryan Michael Reyes, Yilun Deng, Deyi Zhang, Niannian Ji, Neelam Mukherjee, Karen Wheeler, Harshita B Gupta, Alvaro S Padron, Aravind Kancharla, Chenghao Zhang, Myrna Garcia, Anand V R Kornepati, Onur Boyman, Jose R Conejo-Garcia, Robert S Svatek, Tyler J Curiel

Journal for ImmunoTherapy of Cancer Apr 2021, 9 (4) e002051; DOI: 10.1136/jitc-2020-002051
SRC family kinase (SFK) inhibitor dasatinib improves the antitumor activity of anti-PD-1 in NSCLC models by inhibiting Treg cell conversion and proliferation
Esther Redin, Irati Garmendia, Teresa Lozano, Diego Serrano, Yaiza Senent, Miriam Redrado, Maria Villalba, Carlos E De Andrea, Francisco Exposito, Daniel Ajona, Sergio Ortiz-Espinosa, Ana Remirez, Cristina Bertolo, Cristina Sainz, Juana Garcia-Pedrero, Ruben Pio, Juan Lasarte, Jackeline Agorreta, Luis M Montuenga, Alfonso Calvo

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e001496; DOI: 10.1136/jitc-2020-001496

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