Receptors, chimeric antigen

CD8⁺ chimeric antigen receptor T cells manufactured in absence of CD4⁺ cells exhibit hypofunctional phenotype
Sang Yun Lee, Dong Hoon Lee, Wei Sun, Francisco Cervantes-Contreras, Ryan S Basom, Feinan Wu, Si Liu, Richa Rai, Hamid R Mirzaei, Shyril O’Steen, Damian J Green, Mazyar Shadman, Brian G Till

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (11) e007803; DOI: 10.1136/jitc-2023-007803
Framework humanization optimizes potency of anti-CD72 nanobody CAR-T cells for B-cell malignancies
William C Temple, Matthew A Nix, Akul Naik, Adila Izgutdina, Benjamin J Huang, Gianina Wicaksono, Paul Phojanakong, Juan Antonio Camara Serrano, Elizabeth P Young, Emilio Ramos, Fernando Salangsang, Veronica Steri, Simayijiang Xirenayi, Michelle Hermiston, Aaron C Logan, Elliot Stieglitz, Arun P Wiita

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (11) e006985; DOI: 10.1136/jitc-2023-006985
GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma
Tessa Gargett, Lisa M Ebert, Nga T H Truong, Paris M Kollis, Kristyna Sedivakova, Wenbo Yu, Erica C F Yeo, Nicole L Wittwer, Briony L Gliddon, Melinda N Tea, Rebecca Ormsby, Santosh Poonnoose, Jake Nowicki, Orazio Vittorio, David S Ziegler, Stuart M Pitson, Michael P Brown

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e005187; DOI: 10.1136/jitc-2022-005187
Membrane anchored IL-18 linked to constitutively active TLR4 and CD40 improves human T cell antitumor capacities for adoptive cell therapy
Dayana Blokon-Kogan, Maya Levi-Mann, Lior Malka-Levy, Orit Itzhaki, Michal J Besser, Yuval Shiftan, Árpád Szöőr, György Vereb, Gideon Gross, Hinrich Abken, Hadas Weinstein-Marom

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e001544; DOI: 10.1136/jitc-2020-001544
Production and characterization of virus-free, CRISPR-CAR T cells capable of inducing solid tumor regression
Katherine P Mueller, Nicole J Piscopo, Matthew H Forsberg, Louise A Saraspe, Amritava Das, Brittany Russell, Madeline Smerchansky, Dan Cappabianca, Lei Shi, Keerthana Shankar, Lauren Sarko, Namita Khajanchi, Nina La Vonne Denne, Apoorva Ramamurthy, Adeela Ali, Cicera R Lazzarotto, Shengdar Q Tsai, Christian M Capitini, Krishanu Saha

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e004446; DOI: 10.1136/jitc-2021-004446
Association of bridging therapy utilization with clinical outcomes in patients receiving chimeric antigen receptor (CAR) T-cell therapy
P Connor Johnson, Caron Jacobson, Alisha Yi, Mahmoud R Gaballa, Nora Horick, Dustin J Rabideau, Kevin Lindell, Gabriel D DePinho, Areej R El-Jawahri, Matthew J Frigault

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e004567; DOI: 10.1136/jitc-2022-004567
Automated, scaled, transposon-based production of CAR T cells
Dominik Lock, Razieh Monjezi, Caroline Brandes, Stephan Bates, Simon Lennartz, Karin Teppert, Leon Gehrke, Rafailla Karasakalidou-Seidt, Teodora Lukic, Marco Schmeer, Martin Schleef, Niels Werchau, Matthias Eyrich, Mario Assenmacher, Andrew Kaiser, Sabrina Prommersberger, Thomas Schaser, Michael Hudecek

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e005189; DOI: 10.1136/jitc-2022-005189
Imaging cellular immunotherapies and immune cell biomarkers: from preclinical studies to patients
Alessia Volpe, Prasad S Adusumilli, Heiko Schöder, Vladimir Ponomarev

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e004902; DOI: 10.1136/jitc-2022-004902
Generation and proof-of-concept for allogeneic CD123 CAR-Delta One T (DOT) cells in acute myeloid leukemia
Diego Sánchez Martínez, Néstor Tirado, Sofia Mensurado, Alba Martínez-Moreno, Paola Romecín, Francisco Gutiérrez Agüera, Daniel V Correia, Bruno Silva-Santos, Pablo Menéndez

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e005400; DOI: 10.1136/jitc-2022-005400
CAR T-cell detection scoping review: an essential biomarker in critical need of standardization
David P Turicek, Victoria M Giordani, Josquin Moraly, Naomi Taylor, Nirali N Shah

Journal for ImmunoTherapy of Cancer May 2023, 11 (5) e006596; DOI: 10.1136/jitc-2022-006596

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