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BMJ Journals More

T cell anergy/exhaustion

Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8⁺ T cells directly within the tumor microenvironment
Stefani Spranger, Holly K Koblish, Brendan Horton, Peggy A Scherle, Robert Newton, Thomas F Gajewski

Journal for ImmunoTherapy of Cancer Dec 2014, 2 (1) 3; DOI: 10.1186/2051-1426-2-3