Total Body Irradiation

Toll-like receptor agonist therapy can profoundly augment the antitumor activity of adoptively transferred CD8⁺ T cells without host preconditioning
Michelle H. Nelson, Jacob S. Bowers, Stefanie R. Bailey, Marshall A. Diven, Caroline W. Fugle, Andrew D. M. Kaiser, Claudia Wrzesinski, Bei Liu, Nicholas P. Restifo, Chrystal M. Paulos

Journal for ImmunoTherapy of Cancer Dec 2016, 4 (1) 6; DOI: 10.1186/s40425-016-0110-8
Development of an adoptive cell therapy protocol with tumor-infiltrating lymphocytes and intermediate-dose interleukin-2 therapy
Linh T Nguyen, Marcus O Butler, Pei Hua Yen, Jessica Nie, Michael Pniak, Alisha R Elford, Anthony M Joshua, David Hogg, Danny Ghazarian, Ayman Al-Habeeb, Alexandra M Easson, Wey L Leong, David R McCready, Michael Reedijk, Hans A Messner, Pamela S Ohashi

Journal for ImmunoTherapy of Cancer Nov 2013, 1 (Suppl 1) P25; DOI: 10.1186/2051-1426-1-S1-P25
Induction of an acute vitamin A-deficient state following total body irradiation impairs anti-tumor immunity by altering the homeostasis of pre-cDC derived dendritic cells
Christopher A Klebanoff, Sean Spencer, Rahu Roychoudhuri, Yun Ji, Madhu Sukumar, Pawel Muranski, Joseph L Napoli, Luca Gattinoni, Yasmine Belkaid, Nicholas P Restifo

Journal for ImmunoTherapy of Cancer Nov 2013, 1 (Suppl 1) P121; DOI: 10.1186/2051-1426-1-S1-P121
Combined treatment using adoptive cell therapy, extended pharmacokinetic IL-2, and tumor-specific antibodies leads to cures of established B16F10 tumors and extended in vivo T cell survival
Cary F Opel, K Dane Wittrup

Journal for ImmunoTherapy of Cancer Nov 2013, 1 (Suppl 1) P26; DOI: 10.1186/2051-1426-1-S1-P26

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Total Body Irradiation