translational medical research

Intratumoral IL-1R1 expression delineates a distinctive molecular subset with therapeutic resistance in patients with gastric cancer
Puran Zhang, Yun Gu, Hanji Fang, Yifan Cao, Jieti Wang, Hao Liu, Heng Zhang, He Li, Hongyong He, Ruochen Li, Chao Lin, Jiejie Xu

Journal for ImmunoTherapy of Cancer Feb 2022, 10 (2) e004047; DOI: 10.1136/jitc-2021-004047
Single-cell transcriptomics reveals a low CD8⁺ T cell infiltrating state mediated by fibroblasts in recurrent renal cell carcinoma
Yu-Lu Peng, Long-Bin Xiong, Zhao-Hui Zhou, Kang Ning, Zhen Li, Ze-Shen Wu, Min-Hua Deng, Wen-Su Wei, Ning Wang, Xiang-Peng Zou, Zhi-Song He, Ji-Wei Huang, Jun-Hang Luo, Jian-Ye Liu, Nan Jia, Yun Cao, Hui Han, Sheng-Jie Guo, Pei Dong, Chun-Ping Yu, Fang-Jian Zhou, Zhi-Ling Zhang

Journal for ImmunoTherapy of Cancer Feb 2022, 10 (2) e004206; DOI: 10.1136/jitc-2021-004206
Pembrolizumab and decitabine for refractory or relapsed acute myeloid leukemia
Meghali Goswami, Gege Gui, Laura W Dillon, Katherine E Lindblad, Julie Thompson, Janet Valdez, Dong-Yun Kim, Jack Y Ghannam, Karolyn A Oetjen, Christin B Destefano, Dana M Smith, Hanna Tekleab, Yeusheng Li, Pradeep Dagur, Thomas Hughes, Jennifer L Marté, Jaydira del Rivero, Joanna Klubo-Gwiezdzinksa, James L Gulley, Katherine R Calvo, Catherine Lai, Christopher S Hourigan

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003392; DOI: 10.1136/jitc-2021-003392
Systemic high-dose dexamethasone treatment may modulate the efficacy of intratumoral viral oncolytic immunotherapy in glioblastoma models
Marilin S Koch, Mykola Zdioruk, Michal O Nowicki, Alec M Griffith, Estuardo Aguilar, Laura K Aguilar, Brian W Guzik, Francesca Barone, Paul P Tak, Ghazaleh Tabatabai, James A Lederer, E Antonio Chiocca, Sean Lawler

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003368; DOI: 10.1136/jitc-2021-003368
Combination of ultrasound-based mechanical disruption of tumor with immune checkpoint blockade modifies tumor microenvironment and augments systemic antitumor immunity
Shinya Abe, Hiroshi Nagata, Erika J Crosby, Yoshiyuki Inoue, Kensuke Kaneko, Cong-Xiao Liu, Xiao Yang, Tao Wang, Chaitanya R Acharya, Pankaj Agarwal, Joshua Snyder, William Gwin, Michael A Morse, Pei Zhong, Herbert Kim Lyerly, Takuya Osada

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003717; DOI: 10.1136/jitc-2021-003717
Clinical and molecular characteristics associated with response to therapeutic PD-1/PD-L1 inhibition in advanced Merkel cell carcinoma
Ivelina Spassova, Selma Ugurel, Linda Kubat, Lisa Zimmer, Patrick Terheyden, Annalena Mohr, Hannah Björn Andtback, Lisa Villabona, Ulrike Leiter, Thomas Eigentler, Carmen Loquai, Jessica C Hassel, Thilo Gambichler, Sebastian Haferkamp, Peter Mohr, Claudia Pfoehler, Lucie Heinzerling, Ralf Gutzmer, Jochen S Utikal, Kai Horny, Hans-Ulrich Schildhaus, Daniel Habermann, Daniel Hoffmann, Dirk Schadendorf, Jürgen Christian Becker

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003198; DOI: 10.1136/jitc-2021-003198
A very long-acting IL-15: implications for the immunotherapy of cancer
John A Hangasky, Wei Chen, Sigrid P Dubois, Anusara Daenthanasanmak, Jürgen R Müller, Ralph Reid, Thomas A Waldmann, Daniel V Santi

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e004104; DOI: 10.1136/jitc-2021-004104
Anti-CCR4 treatment depletes regulatory T cells and leads to clinical activity in a canine model of advanced prostate cancer
Shingo Maeda, Tomoki Motegi, Aki Iio, Kenjiro Kaji, Yuko Goto-Koshino, Shotaro Eto, Namiko Ikeda, Takayuki Nakagawa, Ryohei Nishimura, Tomohiro Yonezawa, Yasuyuki Momoi

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (2) e003731; DOI: 10.1136/jitc-2021-003731
Interleukin-10 induces expression of CD39 on CD8+T cells to potentiate anti-PD1 efficacy in EGFR-mutated non-small cell lung cancer
Meng Qiao, Fei Zhou, Xinyu Liu, Tao Jiang, Haowei Wang, Yijun Jia, Xuefei Li, Chao Zhao, Lei Cheng, Xiaoxia Chen, Shengxiang Ren, Hongcheng Liu, Caicun Zhou

Journal for ImmunoTherapy of Cancer Dec 2022, 10 (12) e005436; DOI: 10.1136/jitc-2022-005436
Tumor-associated neutrophils and macrophages exacerbate antidrug IgG-mediated anaphylactic reaction against an immune checkpoint inhibitor
Takahiro Arai, Tomomi Kokubo, Ruiheng Tang, Hirohito Abo, Ayu Terui, Jotaro Hirakawa, Hidetaka Akita, Hiroto Kawashima, Akihiro Hisaka, Hiroto Hatakeyama

Journal for ImmunoTherapy of Cancer Dec 2022, 10 (12) e005657; DOI: 10.1136/jitc-2022-005657

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