tumor biomarkers

Gut microbiome is associated with the clinical response to anti-PD-1 based immunotherapy in hepatobiliary cancers
Jinzhu Mao, Dongxu Wang, Junyu Long, Xu Yang, Jianzhen Lin, Yiwei Song, Fucun Xie, Ziyu Xun, Yanyu Wang, Yunchao Wang, Yiran Li, Huishan Sun, Jingnan Xue, Yang Song, Bangyou Zuo, Junwei Zhang, Jin Bian, Ting Zhang, Xiaobo Yang, Lei Zhang, Xinting Sang, Haitao Zhao

Journal for ImmunoTherapy of Cancer Dec 2021, 9 (12) e003334; DOI: 10.1136/jitc-2021-003334
Impact of tumor mutational burden on checkpoint inhibitor drug eligibility and outcomes across racial groups
David Hsiehchen, Magdalena Espinoza, Cristina Valero, Chul Ahn, Luc G T Morris

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e003683; DOI: 10.1136/jitc-2021-003683
Peripherally-driven myeloid NFkB and IFN/ISG responses predict malignancy risk, survival, and immunotherapy regime in ovarian cancer
Jenny Sprooten, Ann Vankerckhoven, Isaure Vanmeerbeek, Daniel M Borras, Yani Berckmans, Roxanne Wouters, Raquel S Laureano, Thais Baert, Louis Boon, Chiara Landolfo, Antonia Carla Testa, Daniela Fischerova, Caroline Van Holsbeke, Tom Bourne, Valentina Chiappa, Wouter Froyman, Dominique Schols, Patrizia Agostinis, Dirk Timmerman, Sabine Tejpar, Ignace Vergote, An Coosemans, Abhishek D Garg

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e003609; DOI: 10.1136/jitc-2021-003609
Immunological configuration of ovarian carcinoma: features and impact on disease outcome
Jitka Fucikova, An Coosemans, Sandra Orsulic, David Cibula, Ignace Vergote, Lorenzo Galluzzi, Radek Spisek

Journal for ImmunoTherapy of Cancer Oct 2021, 9 (10) e002873; DOI: 10.1136/jitc-2021-002873
Increased coexpression of PD-L1 and TIM3/TIGIT is associated with poor overall survival of patients with esophageal squamous cell carcinoma
Peipei Wang, Yueyun Chen, Qingqin Long, Qing Li, Jiangfang Tian, Ting Liu, Yong Wu, Zhenyu Ding

Journal for ImmunoTherapy of Cancer Oct 2021, 9 (10) e002836; DOI: 10.1136/jitc-2021-002836
Distinct mutational profile and immune microenvironment in microsatellite-unstable and POLE-mutated tumors
Hee Sang Hwang, Deokhoon Kim, Jene Choi

Journal for ImmunoTherapy of Cancer Oct 2021, 9 (10) e002797; DOI: 10.1136/jitc-2021-002797
Antitumor immune effects of preoperative sitravatinib and nivolumab in oral cavity cancer: SNOW window-of-opportunity study
Marc Oliva, Douglas Chepeha, Daniel V Araujo, J. Javier Diaz-Mejia, Peter Olson, Amy Prawira, Anna Spreafico, Scott V Bratman, Tina Shek, John de Almeida, Aaron R Hansen, Andrew Hope, David Goldstein, Ilan Weinreb, Stephen Smith, Bayardo Perez-Ordoñez, Jonathan Irish, Dax Torti, Jeffrey P. Bruce, Ben X. Wang, Anthony Fortuna, Trevor J. Pugh, Hirak Der-Torossian, Ronald Shazer, Nickolas Attanasio, Qingyan Au, Antony Tin, Jordan Feeney, Himanshu Sethi, Alexey Aleshin, Isan Chen, Lillian Siu

Journal for ImmunoTherapy of Cancer Oct 2021, 9 (10) e003476; DOI: 10.1136/jitc-2021-003476
PET/CT scan and biopsy-driven approach for safe anti-PD-1 therapy discontinuation in patients with advanced melanoma
Geoffrey T. Gibney, Jacob Zaemes, Shelly Shand, Neil J. Shah, David Swoboda, Kellie Gardner, Arash Radfar, Vesna Petronic-Rosic, Michael J. Reilly, Waddah B. Al-Refaie, Suthee Rapisuwon, Michael B. Atkins

Journal for ImmunoTherapy of Cancer Oct 2021, 9 (10) e002955; DOI: 10.1136/jitc-2021-002955
Immune cell and tumor cell-derived CXCL10 is indicative of immunotherapy response in metastatic melanoma
Robin Reschke, Jovian Yu, Blake A Flood, Emily F Higgs, Ken Hatogai, Thomas F Gajewski

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e003521; DOI: 10.1136/jitc-2021-003521
Assessing tumor heterogeneity: integrating tissue and circulating tumor DNA (ctDNA) analysis in the era of immuno-oncology - blood TMB is not the same as tissue TMB
Stanislav Fridland, Jaeyoun Choi, Myungwoo Nam, Samuel Joseph Schellenberg, Eugene Kim, Grace Lee, Nathaniel Yoon, Young Kwang Chae

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e002551; DOI: 10.1136/jitc-2021-002551

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