Tumor Microenvironment

Quantitative systems pharmacology model predictions for efficacy of atezolizumab and nab-paclitaxel in triple-negative breast cancer
Hanwen Wang, Huilin Ma, Richard J Sové, Leisha A Emens, Aleksander S Popel

Journal for ImmunoTherapy of Cancer Feb 2021, 9 (2) e002100; DOI: 10.1136/jitc-2020-002100
Short-term response to immune-chemotherapy and immune features of a ceritinib-resistant patient with ROS1-rearranged lung adenocarcinoma
Dongsheng Yue, Juanjuan Qian, Zhipeng Chen, Bin Zhang, Peng Chen, Lei Zhang, Jingjing Li, Henghui Zhang, Changli Wang

Journal for ImmunoTherapy of Cancer Feb 2021, 9 (2) e001967; DOI: 10.1136/jitc-2020-001967
Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer
Chunxiao Li, Xiaofei Xu, Shuhua Wei, Ping Jiang, Lixiang Xue, Junjie Wang

Journal for ImmunoTherapy of Cancer Jan 2021, 9 (1) e001341; DOI: 10.1136/jitc-2020-001341
A systemically deliverable Vaccinia virus with increased capacity for intertumoral and intratumoral spread effectively treats pancreatic cancer
Giulia Marelli, Louisa S Chard Dunmall, Ming Yuan, Carmela Di Gioia, Jinxin Miao, Zhenguo Cheng, Zhongxian Zhang, Peng Liu, Jahangir Ahmed, Rathi Gangeswaran, Nicholas Lemoine, Yaohe Wang

Journal for ImmunoTherapy of Cancer Jan 2021, 9 (1) e001624; DOI: 10.1136/jitc-2020-001624
Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist
Punit Upadhyaya, Johanna Lahdenranta, Kristen Hurov, Sailaja Battula, Rachel Dods, Eric Haines, Marianna Kleyman, Julia Kristensson, Jessica Kublin, Rachid Lani, Jun Ma, Gemma Mudd, Elizabeth Repash, Katerine Van Rietschoten, Tom Stephen, Fanglei You, Helen Harrison, Liuhong Chen, Kevin McDonnell, Philip Brandish, Nicholas Keen

Journal for ImmunoTherapy of Cancer Jan 2021, 9 (1) e001762; DOI: 10.1136/jitc-2020-001762
MUC1-C integrates activation of the IFN-γ pathway with suppression of the tumor immune microenvironment in triple-negative breast cancer
Nami Yamashita, Mark Long, Atsushi Fushimi, Masaaki Yamamoto, Tsuyoshi Hata, Masayuki Hagiwara, Atrayee Bhattacharya, Qiang Hu, Kwok-Kin Wong, Song Liu, Donald Kufe

Journal for ImmunoTherapy of Cancer Jan 2021, 9 (1) e002115; DOI: 10.1136/jitc-2020-002115
Targeting PARP-1 with metronomic therapy modulates MDSC suppressive function and enhances anti-PD-1 immunotherapy in colon cancer
Mohamed A Ghonim, Salome V Ibba, Abdelmetalab F Tarhuni, Youssef Errami, Hanh H Luu, Matthew J Dean, Ali H El-Bahrawy, Dorota Wyczechowska, Ilyes A Benslimane, Luis Del Valle, Amir A Al-Khami, Augusto C Ochoa, A Hamid Boulares

Journal for ImmunoTherapy of Cancer Jan 2021, 9 (1) e001643; DOI: 10.1136/jitc-2020-001643
CD8+CD103+ tissue-resident memory T cells convey reduced protective immunity in cutaneous squamous cell carcinoma
Chester Lai, George Coltart, Andrew Shapanis, Conor Healy, Ahmad Alabdulkareem, Sara Selvendran, Jeffrey Theaker, Matthew Sommerlad, Matthew Rose-Zerilli, Aymen Al-Shamkhani, Eugene Healy

Journal for ImmunoTherapy of Cancer Jan 2021, 9 (1) e001807; DOI: 10.1136/jitc-2020-001807
Metastasis-associated macrophages constrain antitumor capability of natural killer cells in the metastatic site at least partially by membrane bound transforming growth factor β
Demi Brownlie, Dahlia Doughty-Shenton, Daniel YH Soong, Colin Nixon, Neil O Carragher, Leo M Carlin, Takanori Kitamura

Journal for ImmunoTherapy of Cancer Jan 2021, 9 (1) e001740; DOI: 10.1136/jitc-2020-001740
Rethinking immune checkpoint blockade: ‘Beyond the T cell’
Xiuting Liu, Graham D Hogg, David G DeNardo

Journal for ImmunoTherapy of Cancer Jan 2021, 9 (1) e001460; DOI: 10.1136/jitc-2020-001460

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