Tumor Microenvironment

Expression of VISTA regulated via IFN-γ governs endogenous T-cell function and exhibits correlation with the efficacy of CD19 CAR-T cell treated B-malignant mice
Donghai Tang, Li Zhao, Fen Yan, Chunxiao Ren, Kailin Xu, Kai Zhao

Journal for ImmunoTherapy of Cancer Jun 2024, 12 (6) e008364; DOI: 10.1136/jitc-2023-008364
EBV promotes TCR-T-cell therapy resistance by inducing CD163+M2 macrophage polarization and MMP9 secretion
Yuanyuan Chen, Dijun Ouyang, Yan Wang, Qiuzhong Pan, Jingjing Zhao, Hao Chen, Xinyi Yang, Yan Tang, Qijing Wang, Yongqiang Li, Jia He, Jin-Qi You, Yingzi Li, Chi Xu, Yan Ren, Sisi Xie, Song Li, Jiamin Lian, Desheng Weng, Tong Xiang, Jian-Chuan Xia

Journal for ImmunoTherapy of Cancer Jun 2024, 12 (6) e008375; DOI: 10.1136/jitc-2023-008375
Exosomal circPOLQ promotes macrophage M2 polarization via activating IL-10/STAT3 axis in a colorectal cancer model
Zhenqiang Sun, Yanxin Xu, Bo Shao, Pengyuan Dang, Shengyun Hu, Haifeng Sun, Chen Chen, Chaoguan Wang, Jinbo Liu, Yang Liu, Junhong Hu

Journal for ImmunoTherapy of Cancer May 2024, 12 (5) e008491; DOI: 10.1136/jitc-2023-008491
Sequence of androgen receptor-targeted vaccination with androgen deprivation therapy affects anti-prostate tumor efficacy
Anusha Muralidhar, Melissa Gamat-Huber, Sita Vakkalanka, Douglas G McNeel

Journal for ImmunoTherapy of Cancer May 2024, 12 (5) e008848; DOI: 10.1136/jitc-2024-008848
Myeloid-derived suppressor cells attenuate the antitumor efficacy of radiopharmaceutical therapy using ⁹⁰Y-NM600 in combination with androgen deprivation therapy in murine prostate tumors
Anusha Muralidhar, Reinier Hernandez, Zachary S Morris, Hansel Comas Rojas, Malick Bio Idrissou, Jamey P Weichert, Douglas G McNeel

Journal for ImmunoTherapy of Cancer Apr 2024, 12 (4) e008760; DOI: 10.1136/jitc-2023-008760
Tumor-agnostic transcriptome-based classifier identifies spatial infiltration patterns of CD8+T cells in the tumor microenvironment and predicts clinical outcome in early-phase and late-phase clinical trials
Andreas Roller, Iakov I Davydov, Petra C Schwalie, Martha L Serrano-Serrano, Astrid Heller, Nicolas Staedler, Cláudia S Ferreira, Gabriele Dietmann, Irina Klaman, Alberto Valdeolivas, Konstanty Korski, Michael A Cannarile

Journal for ImmunoTherapy of Cancer Apr 2024, 12 (4) e008185; DOI: 10.1136/jitc-2023-008185
Preclinical evaluation of two phylogenetically distant arenavirus vectors for the development of novel immunotherapeutic combination strategies for cancer treatment
Josipa Raguz, Catarina Pinto, Theresa Pölzlbauer, Mohamed Habbeddine, Sandra Rosskopf, Judith Strauß, Valentin Just, Sarah Schmidt, Katell Bidet Huang, Felix Stemeseder, Timo Schippers, Ethan Stewart, Jakub Jez, Pedro Berraondo, Klaus K. Orlinger, Henning Lauterbach

Journal for ImmunoTherapy of Cancer Apr 2024, 12 (4) e008286; DOI: 10.1136/jitc-2023-008286
Phase 1 study combining elotuzumab with autologous stem cell transplant and lenalidomide for multiple myeloma
David G Coffey, Keren Osman, Adolfo Aleman, Selma Bekri, Simone Kats, Amishi Dhadwal, Donna Catamero, Seunghee Kim-Schulze, Sacha Gnjatic, Ajai Chari, Samir Parekh, Sundar Jagannath, Hearn Jay Cho

Journal for ImmunoTherapy of Cancer Apr 2024, 12 (4) e008110; DOI: 10.1136/jitc-2023-008110
Armored TGFβRIIDN ROR1-CAR T cells reject solid tumors and resist suppression by constitutively-expressed and treatment-induced TGFβ1
Tri Minh Tran, Bal Krishna Chand Thakuri, Saule Nurmukhambetova, Jia-Jye Lee, Peirong Hu, Ngoc Q Tran, Brittany Steimle, Pradyot Dash, Dina Schneider

Journal for ImmunoTherapy of Cancer Apr 2024, 12 (4) e008261; DOI: 10.1136/jitc-2023-008261
Blocking senescence and tolerogenic function of dendritic cells induced by γδ Treg cells enhances tumor-specific immunity for cancer immunotherapy
Fusheng Si, Xia Liu, Yan Tao, Yuanqin Zhang, Feiya Ma, Eddy C Hsueh, Sidharth V Puram, Guangyong Peng

Journal for ImmunoTherapy of Cancer Apr 2024, 12 (4) e008219; DOI: 10.1136/jitc-2023-008219

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