Tumor Microenvironment

Fibrinogen-like protein 2 promotes tumor immune suppression by regulating cholesterol metabolism in myeloid-derived suppressor cells
Lei Wu, Xudong Liu, Juan Lei, Nan Zhang, Huakan Zhao, Jiangang Zhang, Huan Deng, Yongsheng Li

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e008081; DOI: 10.1136/jitc-2023-008081
Tumor cell-intrinsic SETD2 inactivation sensitizes cancer cells to immune checkpoint blockade through the NR2F1-STAT1 pathway
Xufen Zheng, Yuxiang Luo, Yangjie Xiong, Xiaoxiao Liu, Chunling Zeng, Xiaojing Lu, Xiaofang Wang, Yumei Cheng, Simin Wang, Haoqi Lan, Kai Wang, Zhonghui Weng, Wenbo Bi, Xinxin Gan, Xiaona Jia, Linhui Wang, Yuexiang Wang

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e007678; DOI: 10.1136/jitc-2023-007678
CXCL10 and Nrf2-upregulated mesenchymal stem cells reinvigorate T lymphocytes for combating glioblastoma
Jiaji Mao, Jianing Li, Junwei Chen, Qin Wen, Minghui Cao, Fang Zhang, Baoxun Li, Qinyuan Zhang, Zhe Wang, Jingzhong Zhang, Jun Shen

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e007481; DOI: 10.1136/jitc-2023-007481
Targeting integrin α5 in fibroblasts potentiates colorectal cancer response to PD-L1 blockade by affecting extracellular-matrix deposition
Ling Lu, Yaohui Gao, Dengfeng Huang, Hu Liu, Dingzi Yin, Man Li, Jiayi Zheng, Shufei Wang, Weijun Wu, Li Zhao, Dexi Bi, Youhua Zhang, Feifei Song, Ruting Xie, Jifeng Wang, Huanlong Qin, Qing Wei

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e007447; DOI: 10.1136/jitc-2023-007447
Heterogeneity in tertiary lymphoid structures predicts distinct prognosis and immune microenvironment characterizations of clear cell renal cell carcinoma
Wenhao Xu, Jiahe Lu, Wang-Rui Liu, Aihetaimujiang Anwaier, Yuhao Wu, Xi Tian, Jia-Qi Su, Yuan-Yuan Qu, Jianfeng Yang, Hailiang Zhang, Dingwei Ye

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e006667; DOI: 10.1136/jitc-2023-006667
Methylglyoxal from gut microbes boosts radiosensitivity and radioimmunotherapy in rectal cancer by triggering endoplasmic reticulum stress and cGAS-STING activation
Han Zhou, Lei Wang, Zhiwen Lin, Chenwei Jiang, Xingte Chen, Kai Wang, Libin Liu, Lingdong Shao, Jianji Pan, Jinluan Li, Da Zhang, Junxin Wu

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (11) e007840; DOI: 10.1136/jitc-2023-007840
Delayed vaccine-induced CD8⁺ T cell expansion by topoisomerase I inhibition mediates enhanced CD70-dependent tumor eradication
Tetje C van der Sluis, Floortje J van Haften, Suzanne van Duikeren, Iris N Pardieck, J Fréderique de Graaf, Ward Vleeshouwers, Koen van der Maaden, Cornelis J M Melief, Sjoerd H van der Burg, Ramon Arens

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (11) e007158; DOI: 10.1136/jitc-2023-007158
TP53/mTORC1-mediated bidirectional regulation of PD-L1 modulates immune evasion in hepatocellular carcinoma
Jiongjie Yu, Sunbin Ling, Jiachen Hong, Lincheng Zhang, Wei Zhou, Lu Yin, Shengjun Xu, Qingyang Que, Yongfeng Wu, Qifan Zhan, Jiaqi Bao, Nan Xu, Yuchen Liu, Kangchen Chen, Xuyong Wei, Zhikun Liu, Tingting Feng, Lin Zhou, Haiyang Xie, Shuai Wang, Jimin Liu, Shusen Zheng, Xiao Xu

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (11) e007479; DOI: 10.1136/jitc-2023-007479
High-dimensional single-cell proteomics analysis of esophageal squamous cell carcinoma reveals dynamic alterations of the tumor immune microenvironment after neoadjuvant therapy
Dingpei Han, Yichao Han, Wei Guo, Wei Wei, Su Yang, Jie Xiang, Jiaming Che, Lianggang Zhu, Junbiao Hang, Tom van den Ende, Hanneke W M van Laarhoven, Bin Li, Youqiong Ye, Hecheng Li

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (11) e007847; DOI: 10.1136/jitc-2023-007847
Guidelines for immunological analyses following focused ultrasound treatment
Frederic Padilla, Jessica Foley, Kelsie Timbie, Timothy N J Bullock, Natasha D Sheybani

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (11) e007455; DOI: 10.1136/jitc-2023-007455

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