Tumor Microenvironment

GDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma
Zhaowei Wang, Lei He, Weina Li, Chuanyang Xu, Jieyu Zhang, Desheng Wang, Kefeng Dou, Ran Zhuang, Boquan Jin, Wei Zhang, Qiang Hao, Kuo Zhang, Wangqian Zhang, Shuning Wang, Yuan Gao, Jintao Gu, Lei Shang, Zhijun Tan, Haichuan Su, Yingqi Zhang, Cun Zhang, Meng Li

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002787; DOI: 10.1136/jitc-2021-002787
Matter of TIME: the tumor-immune microenvironment of mesothelioma and implications for checkpoint blockade efficacy
James Harber, Tamihiro Kamata, Catrin Pritchard, Dean Fennell

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e003032; DOI: 10.1136/jitc-2021-003032
Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes
Mikako Nishida, Nahoko Yamashita, Taisaku Ogawa, Keita Koseki, Eiji Warabi, Tomoyuki Ohue, Masaaki Komatsu, Hirokazu Matsushita, Kazuhiro Kakimi, Eiryo Kawakami, Katsuyuki Shiroguchi, Heiichiro Udono

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002954; DOI: 10.1136/jitc-2021-002954
Leveraging the Treg-intrinsic CTLA4–PKCη signaling pathway for cancer immunotherapy
Hsin-Yu Liu, Christophe Pedros, Kok-Fai Kong, Ann J Canonigo-Balancio, Wen Xue, Amnon Altman

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002792; DOI: 10.1136/jitc-2021-002792
Elucidating mechanisms of antitumor immunity mediated by live oncolytic vaccinia and heat-inactivated vaccinia
Weiyi Wang, Shuaitong Liu, Peihong Dai, Ning Yang, Yi Wang, Rachel A Giese, Taha Merghoub, Jedd Wolchok, Liang Deng

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002569; DOI: 10.1136/jitc-2021-002569
Phase II study of pembrolizumab in refractory esophageal cancer with correlates of response and survival
Leonie K de Klerk, Anuj K Patel, Sarah Derks, Eirini Pectasides, Jeremy Augustin, Mohamed Uduman, Nihal Raman, Fahire G Akarca, Nadine J McCleary, James M Cleary, Douglas A Rubinson, Jeffrey W Clark, Bridget Fitzpatrick, Lauren K Brais, Megan E Cavanaugh, Amanda J Rode, Melissa G Jean, Patrick H Lizotte, Matthew J Nazzaro, Mariano Severgnini, Hui Zheng, Charles S Fuchs, Peter C Enzinger, Adam J Bass

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002472; DOI: 10.1136/jitc-2021-002472
Immune cell and tumor cell-derived CXCL10 is indicative of immunotherapy response in metastatic melanoma
Robin Reschke, Jovian Yu, Blake A Flood, Emily F Higgs, Ken Hatogai, Thomas F Gajewski

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e003521; DOI: 10.1136/jitc-2021-003521
Loss of host tissue transglutaminase boosts antitumor T cell immunity by altering STAT1/STAT3 phosphorylation in ovarian cancer
Livia Elena Sima, Siqi Chen, Horacio Cardenas, Guangyuan Zhao, Yinu Wang, Cristina Ivan, Hao Huang, Bin Zhang, Daniela Matei

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002682; DOI: 10.1136/jitc-2021-002682
Profiling specific cell populations within the inflammatory tumor microenvironment by oscillating-gradient diffusion-weighted MRI
Emily Hoffmann, Mirjam Gerwing, Stephan Niland, Rolf Niehoff, Max Masthoff, Christiane Geyer, Lydia Wachsmuth, Enrica Wilken, Carsten Höltke, Walter L Heindel, Verena Hoerr, Regina Schinner, Philipp Berger, Thomas Vogl, Johannes A Eble, Bastian Maus, Anne Helfen, Moritz Wildgruber, Cornelius Faber

Journal for ImmunoTherapy of Cancer Mar 2023, 11 (3) e006092; DOI: 10.1136/jitc-2022-006092
BHLHE22 drives the immunosuppressive bone tumor microenvironment and associated bone metastasis in prostate cancer
Chi Yin, Min Wang, Yingzhao Wang, Qijun Lin, Kaiyuan Lin, Hong Du, Chuandong Lang, Yuhu Dai, Xinsheng Peng

Journal for ImmunoTherapy of Cancer Mar 2023, 11 (3) e005532; DOI: 10.1136/jitc-2022-005532

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