Tumor Microenvironment

TGFβ-specific T cells induced by a TGFβ-derived immune modulatory vaccine both directly and indirectly modulate the phenotype of tumor-associated macrophages and fibroblasts
Maria Perez-Penco, Lucia Lara de la Torre, Inés Lecoq, Evelina Martinenaite, Mads Hald Andersen

Journal for ImmunoTherapy of Cancer Feb 2024, 12 (2) e008405; DOI: 10.1136/jitc-2023-008405
Machine learning analysis of pathological images to predict 1-year progression-free survival of immunotherapy in patients with small-cell lung cancer
Ryota Shibaki, Daichi Fujimoto, Tsukasa Nozawa, Akira Sano, Yuka Kitamura, Junya Fukuoka, Yuki Sato, Takashi Kijima, Hirotaka Matsumoto, Toshihide Yokoyama, Satoru Miura, Akito Hata, Motohiro Tamiya, Yoshihiko Taniguchi, Jun Sugisaka, Naoki Furuya, Hisashi Tanaka, Nobuyuki Yamamoto, Yasuhiro Koh, Hiroaki Akamatsu

Journal for ImmunoTherapy of Cancer Feb 2024, 12 (2) e007987; DOI: 10.1136/jitc-2023-007987
Phase 1/2 study of monalizumab plus durvalumab in patients with advanced solid tumors
Sandip P Patel, Teresa Alonso-Gordoa, Susana Banerjee, Ding Wang, Jarushka Naidoo, Nathan E Standifer, Doug C Palmer, Lin-Yang Cheng, Panagiotis Kourtesis, Maria L Ascierto, Mayukh Das, Jennifer R Diamond, Matthew D Hellmann, Benedito A Carneiro

Journal for ImmunoTherapy of Cancer Feb 2024, 12 (2) e007340; DOI: 10.1136/jitc-2023-007340
First exploration of the on-treatment changes in tumor and organ uptake of a radiolabeled anti PD-L1 antibody during chemoradiotherapy in patients with non-small cell lung cancer using whole body PET
Johanna E E Pouw, Sayed M S Hashemi, Marc C Huisman, Jessica E Wijngaarden, Maarten Slebe, Daniela E Oprea-Lager, Gerben J C Zwezerijnen, Danielle Vugts, Ezgi B Ulas, Tanja D de Gruijl, Teodora Radonic, Suresh Senan, C Willemien Menke-van der Houven van Oordt, Idris Bahce

Journal for ImmunoTherapy of Cancer Feb 2024, 12 (2) e007659; DOI: 10.1136/jitc-2023-007659
Peritumoral administration of immunomodulatory antibodies as a triple combination suppresses skin tumor growth without systemic toxicity
Quentin G Wright, Debottam Sinha, James W Wells, Ian H Frazer, Jazmina L Gonzalez Cruz, Graham Robert Leggatt

Journal for ImmunoTherapy of Cancer Jan 2024, 12 (1) e007960; DOI: 10.1136/jitc-2023-007960
CARs are sharpening their weapons
Alice Pievani, Marta Biondi, Sarah Tettamanti, Andrea Biondi, Gianpietro Dotti, Marta Serafini

Journal for ImmunoTherapy of Cancer Jan 2024, 12 (1) e008275; DOI: 10.1136/jitc-2023-008275
Multimodal profiling of chordoma immunity reveals distinct immune contextures
Siddh van Oost, Debora M Meijer, Marieke E Ijsselsteijn, Jessica P Roelands, Brendy E M W van den Akker, Ruud van der Breggen, Inge H Briaire-de Bruijn, Manon van der Ploeg, Pauline M Wijers-Koster, Samuel B Polak, Wilco C Peul, Robert J P van der Wal, Noel F C C de Miranda, Judith V M G Bovee

Journal for ImmunoTherapy of Cancer Jan 2024, 12 (1) e008138; DOI: 10.1136/jitc-2023-008138
Inhibiting PLA2G7 reverses the immunosuppressive function of intratumoral macrophages and augments immunotherapy response in hepatocellular carcinoma
Feng Zhang, Wenfeng Liu, Fansheng Meng, Qiuyu Jiang, Wenqing Tang, Zhiyong Liu, Xiahui Lin, Ruyi Xue, Si Zhang, Ling Dong

Journal for ImmunoTherapy of Cancer Jan 2024, 12 (1) e008094; DOI: 10.1136/jitc-2023-008094
Cryoablation triggers type I interferon-dependent antitumor immunity and potentiates immunotherapy efficacy in lung cancer
Chuanjia Gu, Xue Wang, Kaiyu Wang, Fangfang Xie, Luonan Chen, Hongbin Ji, Jiayuan Sun

Journal for ImmunoTherapy of Cancer Jan 2024, 12 (1) e008386; DOI: 10.1136/jitc-2023-008386
Hypoxia-inducible lentiviral gene expression in engineered human macrophages
Harrison K Chinn, Jennifer L Gardell, Lisa R Matsumoto, Kevin P Labadie, Tara N Mihailovic, Nicole A P Lieberman, Amira Davis, Venu G Pillarisetty, Courtney A Crane

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e003770; DOI: 10.1136/jitc-2021-003770

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