Tumor Microenvironment

Inhibition of tumor intrinsic BANF1 activates antitumor immune responses via cGAS-STING and enhances the efficacy of PD-1 blockade
Minglei Wang, Yiheng Huang, Minxin Chen, Weiyan Wang, Fei Wu, Tao Zhong, Xiaozheng Chen, Fei Wang, Yang Li, Jinming Yu, Meng Wu, Dawei Chen

Journal for ImmunoTherapy of Cancer Aug 2023, 11 (8) e007035; DOI: 10.1136/jitc-2023-007035
C1q⁺ tumor-associated macrophages contribute to immunosuppression through fatty acid metabolic reprogramming in malignant pleural effusion
Siyu Zhang, Wenbei Peng, Haolei Wang, Xuan Xiang, Linlin Ye, Xiaoshan Wei, Zihao Wang, Qianqian Xue, Long Chen, Yuan Su, Qiong Zhou

Journal for ImmunoTherapy of Cancer Aug 2023, 11 (8) e007441; DOI: 10.1136/jitc-2023-007441
TP53 gain-of-function mutation modulates the immunosuppressive microenvironment in non-HPV-associated oral squamous cell carcinoma
Yewen Shi, Xiaoyong Ren, Shaolong Cao, Xi Chen, Bo Yuan, Fabio Henrique Brasil da Costa, Alanis E Rodriguez Rosario, Arnoldo Corona, Chieko Michikawa, Ratna Veeramachaneni, Abdullah A Osman, Tongxin Xie, Wenyi Wang, Andrew G Sikora, Jeffrey N Myers, Roberto Rangel

Journal for ImmunoTherapy of Cancer Aug 2023, 11 (8) e006666; DOI: 10.1136/jitc-2023-006666
Low molecular weight heparin synergistically enhances the efficacy of adoptive and anti-PD-1-based immunotherapy by increasing lymphocyte infiltration in colorectal cancer
Yibo Quan, Jie He, Qi Zou, Liuxi Zhang, Qihui Sun, Hongli Huang, Wanglin Li, Keping Xie, Fang Wei

Journal for ImmunoTherapy of Cancer Aug 2023, 11 (8) e007080; DOI: 10.1136/jitc-2023-007080
Targeting sphingosine 1-phosphate receptor 3 inhibits T-cell exhaustion and regulates recruitment of proinflammatory macrophages to improve antitumor efficacy of CAR-T cells against solid tumor
Ge Gao, Weiting Liao, Pei Shu, Qizhi Ma, Xia He, Benxia Zhang, Diyuan Qin, Yongsheng Wang

Journal for ImmunoTherapy of Cancer Aug 2023, 11 (8) e006343; DOI: 10.1136/jitc-2022-006343
Immune dysfunction revealed by digital spatial profiling of immuno-oncology markers in progressive stages of renal cell carcinoma and in brain metastases
David A Schoenfeld, Myrto Moutafi, Sandra Martinez, Dijana Djureinovic, Ross D Merkin, Adebowale Adeniran, David A Braun, Sabina Signoretti, Toni K Choueiri, Fabio Parisi, Michael Hurwitz, David L Rimm, Wei Wei, Lucia Jilaveanu, Harriet M Kluger

Journal for ImmunoTherapy of Cancer Aug 2023, 11 (8) e007240; DOI: 10.1136/jitc-2023-007240
PPARγ activation modulates the balance of peritoneal macrophage populations to suppress ovarian tumor growth and tumor-induced immunosuppression
Mélissa Prat, Kimberley Coulson, Clément Blot, Godefroy Jacquemin, Mathilde Romano, Marie-Laure Renoud, Mohamad AlaEddine, Augustin Le Naour, Hélène Authier, Mouna Chirine Rahabi, Khaddouj Benmoussa, Marie Salon, Mélissa Parny, Jean-Pierre Delord, Gwenaël Ferron, Lise Lefèvre, Bettina Couderc, Agnès Coste

Journal for ImmunoTherapy of Cancer Aug 2023, 11 (8) e007031; DOI: 10.1136/jitc-2023-007031
KLF12 overcomes anti-PD-1 resistance by reducing galectin-1 in cancer cells
Yujia Zheng, Hao Zhang, Chu Xiao, Ziqin Deng, Tao Fan, Bo Zheng, Chunxiang Li, Jie He

Journal for ImmunoTherapy of Cancer Aug 2023, 11 (8) e007286; DOI: 10.1136/jitc-2023-007286
Functional tumor cell-intrinsic STING, not host STING, drives local and systemic antitumor immunity and therapy efficacy following cryoablation
Mohammad Alshebremi, Suzanne L Tomchuck, Jay T Myers, Daniel T Kingsley, Saada Eid, Muta Abiff, Melissa Bonner, Shahrazad T Saab, Sung Hee Choi, Alex Yee-Chen Huang

Journal for ImmunoTherapy of Cancer Aug 2023, 11 (8) e006608; DOI: 10.1136/jitc-2022-006608
Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma
Vincenzo Graziano, Andreas Dannhorn, Heather Hulme, Kate Williamson, Hannah Buckley, Saadia A Karim, Matthew Wilson, Sheng Y Lee, Brajesh P Kaistha, Sabita Islam, James E D Thaventhiran, Frances M Richards, Richard Goodwin, Rebecca Brais, Jennifer P Morton, Simon J Dovedi, Alwin G Schuller, Jim Eyles, Duncan I Jodrell

Journal for ImmunoTherapy of Cancer Aug 2023, 11 (8) e006457; DOI: 10.1136/jitc-2022-006457

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